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BRCA1 L1407P [nucleoplasm]
Stable Identifier
R-HSA-9702135
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
BRCA1 Leu1407Pro
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of DNA Double-Strand Break Repair (Homo sapiens)
Defective homologous recombination repair (HRR) due to BRCA1 loss of function (Homo sapiens)
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)
Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Homo sapiens)
Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Homo sapiens)
Defective BRCA1-C complex [nucleoplasm] (Homo sapiens)
Defective p-5S-BRCA1:p-2T-BARD1 [nucleoplasm] (Homo sapiens)
BRCA1 mutants (PALB2 binding) [nucleoplasm] (Homo sapiens)
BRCA1 L1407P [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
19369211
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
Sy, SM
,
Huen, MS
,
Chen, J
Proc Natl Acad Sci U S A
2009
External Reference Information
External Reference
UniProt:P38398 BRCA1
Gene Names
BRCA1, RNF53
Chain
chain:1-1863
Reference Genes
BioGPS Gene:672 BRCA1
COSMIC (genes):BRCA1 BRCA1
CTD Gene:672 BRCA1
dbSNP Gene:672 BRCA1
ENSEMBL:ENSG00000012048 BRCA1
ENSEMBL_homo_sapiens_GENE:ENSG00000012048.25 BRCA1
HGNC:1100 BRCA1
KEGG Gene (Homo sapiens):672 BRCA1
Monarch:672 BRCA1
NCBI Gene:672 BRCA1
OMIM:113705 BRCA1
UCSC:P38398 BRCA1
Reference Transcript
RefSeq:NM_007299.3 BRCA1
RefSeq:NM_007297.3 BRCA1
RefSeq:NM_007294.3 BRCA1
RefSeq:NM_007300.3 BRCA1
RefSeq:NM_007298.3 BRCA1
Other Identifiers
11735584_x_at
11744317_x_at
11749632_a_at
11750373_a_at
11755416_x_at
16845349
1993_s_at
204531_PM_s_at
204531_s_at
211851_PM_x_at
211851_x_at
2395433
33724_at
3506844
3758316
3758318
3758319
3758321
3758323
3758324
3758334
3758335
3758337
3758341
3758342
3758344
3758345
3758350
3758351
3758355
3758357
3758358
3758359
3758360
3758361
3758362
3758363
3758364
3758366
3758367
3758368
3758371
3758372
3758374
3758375
604_at
672
69578_at
8015769
A_23_P207400
GE475511
GE59309
GO:0000151
GO:0000152
GO:0000228
GO:0000278
GO:0000724
GO:0000793
GO:0000794
GO:0000800
GO:0000931
GO:0000976
GO:0001216
GO:0001673
GO:0001741
GO:0002039
GO:0003677
GO:0003684
GO:0003713
GO:0003723
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005815
GO:0005856
GO:0005886
GO:0006260
GO:0006281
GO:0006282
GO:0006301
GO:0006302
GO:0006310
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006629
GO:0006631
GO:0006633
GO:0006974
GO:0007010
GO:0007049
GO:0007059
GO:0007095
GO:0007098
GO:0008092
GO:0008270
GO:0008630
GO:0009048
GO:0010212
GO:0010575
GO:0010628
GO:0012501
GO:0015631
GO:0016567
GO:0016604
GO:0016740
GO:0019899
GO:0023052
GO:0030308
GO:0031436
GO:0031625
GO:0032991
GO:0033147
GO:0035066
GO:0035067
GO:0035825
GO:0036211
GO:0042802
GO:0043009
GO:0043226
GO:0043232
GO:0044027
GO:0044818
GO:0045717
GO:0045739
GO:0045766
GO:0045786
GO:0045892
GO:0045893
GO:0045944
GO:0046600
GO:0046872
GO:0048856
GO:0051179
GO:0051726
GO:0051865
GO:0060816
GO:0070063
GO:0070531
GO:0070532
GO:0070533
GO:0071356
GO:0071479
GO:0071681
GO:0085020
GO:0110025
GO:0140096
GO:0140110
GO:1902042
GO:1990391
GO:1990904
GO:2000001
GO:2000378
HMNXSV003012854
ILMN_1738027
ILMN_2311089
L78833_cds1_at
PH_hs_0011459
TC17001553.hg
TC17002645.hg
U64805_s_at
g2218153_3p_a_at
g6552300_3p_a_at
Participates
as a member of
BRCA1 mutants (PALB2 binding) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
polySUMO2,3-BRCA1 [nucleoplasm]
monoSUMO1-K109-BRCA1 [nucleoplasm]
BRCA1 M1411T [nucleoplasm]
BRCA1 M1400V [nucleoplasm]
BRCA1 Y777* [nucleoplasm]
BRCA1 S1009* [nucleoplasm]
BRCA1 P724Lfs*12 [nucleoplasm]
BRCA1 S451* [nucleoplasm]
BRCA1 S864* [nucleoplasm]
BRCA1 P897Kfs*5 [nucleoplasm]
BRCA1 N555Kfs*17 [nucleoplasm]
BRCA1 Y1127Sfs*6 [nucleoplasm]
BRCA1 S886Cfs*16 [nucleoplasm]
BRCA1 V83Cfs*2 [nucleoplasm]
BRCA1 T464Pfs*11 [nucleoplasm]
BRCA1 G813Dfs*2 [nucleoplasm]
BRCA1 V340Gfs*6 [nucleoplasm]
BRCA1 Y655* [nucleoplasm]
BRCA1 W372* [nucleoplasm]
BRCA1 Y655Vfs*18 [nucleoplasm]
BRCA1 S242Rfs*5 [nucleoplasm]
BRCA1 E111Gfs*3 [nucleoplasm]
BRCA1 R71Kfs*10 [nucleoplasm]
BRCA1 A224Gfs*4 [nucleoplasm]
BRCA1 Q317* [nucleoplasm]
BRCA1 E1004* [nucleoplasm]
BRCA1 Q541* [nucleoplasm]
BRCA1 Q667* [nucleoplasm]
BRCA1 N909Kfs*6 [nucleoplasm]
BRCA1 T922Lfs*77 [nucleoplasm]
BRCA1 N567Pfs*16 [nucleoplasm]
BRCA1 N555Ifs*17 [nucleoplasm]
BRCA1 S988* [nucleoplasm]
BRCA1 S1007* [nucleoplasm]
BRCA1 E1288Kfs*19 [nucleoplasm]
BRCA1 V1176Ffs*34 [nucleoplasm]
BRCA1 S1217Rfs*21 [nucleoplasm]
BRCA1 E1282Afs*26 [nucleoplasm]
BRCA1 Q210Sfs*6 [nucleoplasm]
BRCA1 E453Rfs*22 [nucleoplasm]
BRCA1 E729Rfs*10 [nucleoplasm]
BRCA1 R1203* [nucleoplasm]
BRCA1 E686* [nucleoplasm]
BRCA1 R388* [nucleoplasm]
BRCA1 L290Yfs*8 [nucleoplasm]
BRCA1 E648* [nucleoplasm]
BRCA1 N1045* [nucleoplasm]
BRCA1 Q172Nfs*62 [nucleoplasm]
BRCA1 D1156Cfs*2 [nucleoplasm]
BRCA1 E597* [nucleoplasm]
BRCA1 Q210* [nucleoplasm]
BRCA1 E515* [nucleoplasm]
BRCA1 N287Qfs*6 [nucleoplasm]
BRCA1 Q169* [nucleoplasm]
BRCA1 N1121Kfs*12 [nucleoplasm]
BRCA1 E572* [nucleoplasm]
BRCA1 L1276* [nucleoplasm]
BRCA1 L431* [nucleoplasm]
BRCA1 E1214* [nucleoplasm]
BRCA1 L474* [nucleoplasm]
BRCA1 L502Afs*2 [nucleoplasm]
BRCA1 E1013Nfs*4 [nucleoplasm]
BRCA1 E1112Dfs*5 [nucleoplasm]
BRCA1 Q1144* [nucleoplasm]
BRCA1 Q94* [nucleoplasm]
BRCA1 N1265Kfs*4 [nucleoplasm]
BRCA1 C1146Lfs*8 [nucleoplasm]
BRCA1 Q934* [nucleoplasm]
BRCA1 D295Tfs*3 [nucleoplasm]
BRCA1 R1188Efs*3 [nucleoplasm]
BRCA1 C1225Sfs*10 [nucleoplasm]
BRCA1 R446Sfs*9 [nucleoplasm]
BRCA1 L668Pfs*33 [nucleoplasm]
BRCA1 A521Qfs*11 [nucleoplasm]
BRCA1 N1029Kfs*3 [nucleoplasm]
BRCA1 E1115* [nucleoplasm]
BRCA1 Q544* [nucleoplasm]
BRCA1 E577* [nucleoplasm]
BRCA1 P115* [nucleoplasm]
BRCA1 Q126* [nucleoplasm]
BRCA1 E457* [nucleoplasm]
BRCA1 A878Gfs*24 [nucleoplasm]
BRCA1 Q1281* [nucleoplasm]
BRCA1 Q202* [nucleoplasm]
BRCA1 N714Kfs*4 [nucleoplasm]
BRCA1 Q1240* [nucleoplasm]
BRCA1 K1183Rfs*4 [nucleoplasm]
BRCA1 K654Sfs*47 [nucleoplasm]
BRCA1 K1254Nfs*11 [nucleoplasm]
BRCA1 E1167* [nucleoplasm]
BRCA1 K1037* [nucleoplasm]
BRCA1 G911* [nucleoplasm]
BRCA1 G535* [nucleoplasm]
BRCA1 E111* [nucleoplasm]
BRCA1 E1107* [nucleoplasm]
BRCA1 E1033* [nucleoplasm]
BRCA1 E149* [nucleoplasm]
BRCA1 E1250* [nucleoplasm]
BRCA1 K467* [nucleoplasm]
BRCA1 E272* [nucleoplasm]
BRCA1 E1258* [nucleoplasm]
BRCA1 E1210* [nucleoplasm]
BRCA1 K1160* [nucleoplasm]
BRCA1 K519* [nucleoplasm]
BRCA1 E1112* [nucleoplasm]
BRCA1 E116* [nucleoplasm]
BRCA1 K935* [nucleoplasm]
BRCA1 K800* [nucleoplasm]
BRCA1 K894Tfs*8 [nucleoplasm]
BRCA1 K339Rfs*2 [nucleoplasm]
BRCA1 L1086Dfs*2 [nucleoplasm]
BRCA1 I986Sfs*14 [nucleoplasm]
BRCA1 K1079Nfs*2 [nucleoplasm]
BRCA1 K739Ifs*15 [nucleoplasm]
BRCA1 I925Nfs*13 [nucleoplasm]
BRCA1 K608Ifs*3 [nucleoplasm]
BRCA1 K893Rfs*107 [nucleoplasm]
BRCA1 H437* [nucleoplasm]
BRCA1 H816Qfs*3 [nucleoplasm]
BRCA1 F989Lfs*10 [nucleoplasm]
BRCA1 G928Afs*72 [nucleoplasm]
BRCA1 W372Yfs*5 [nucleoplasm]
BRCA1 E75Kfs*13 [nucleoplasm]
BRCA1 G948Efs*52 [nucleoplasm]
BRCA1 V757Ffs*8 [nucleoplasm]
BRCA1 H1284Tfs*23 [nucleoplasm]
BRCA1 E733* [nucleoplasm]
BRCA1 F869Vfs*35 [nucleoplasm]
BRCA1 E720* [nucleoplasm]
BRCA1 S426* [nucleoplasm]
BRCA1 E673* [nucleoplasm]
BRCA1 E787* [nucleoplasm]
BRCA1 E881* [nucleoplasm]
BRCA1 E848* [nucleoplasm]
BRCA1 E842* [nucleoplasm]
BRCA1 F989Lfs*11 [nucleoplasm]
BRCA1 G817Vfs*29 [nucleoplasm]
BRCA1 E836* [nucleoplasm]
BRCA1 G911Efs*89 [nucleoplasm]
BRCA1 E904* [nucleoplasm]
BRCA1 C64R [nucleoplasm]
BRCA1 C61G [nucleoplasm]
BRCA1 C39Y [nucleoplasm]
BRCA1 H41R [nucleoplasm]
BRCA1 C24R [nucleoplasm]
BRCA1 H41A [nucleoplasm]
BRCA1 M18T [nucleoplasm]
BRCA1 C47G [nucleoplasm]
BRCA1 C64G [nucleoplasm]
BRCA1 C44F [nucleoplasm]
BRCA1 T37R [nucleoplasm]
BRCA1 C27A [nucleoplasm]
BRCA1 H41Q [nucleoplasm]
BRCA1 Q12Tfs*5 [nucleoplasm]
BRCA1 E23Afs*18 [nucleoplasm]
BRCA1 C61Y [nucleoplasm]
BRCA1 C24F [nucleoplasm]
BRCA1 E23Rfs*18 [nucleoplasm]
BRCA1 E23Vfs*17 [nucleoplasm]
K6PolyUb,p-S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]
p-S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]
K6PolyUb-BRCA1 [nucleoplasm]
BRCA1 [nucleoplasm]
p-S988,S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]
K6PolyUb,p-S988,S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]
Modified Residues
Name
L-leucine 1407 replaced with L-proline
Coordinate
1407
PsiMod
L-leucine removal [MOD:01641]
A protein modification that effectively removes or replaces an L-leucine.
L-proline residue [MOD:00024]
A protein modification that effectively converts a source amino acid residue to L-proline.
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
breast cancer
DOID:1612
malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
Cross References
RefSeq
NP_009228.2
,
NP_009225.1
,
NP_009230.2
,
NP_009231.2
,
NP_009229.2
ClinGen
CA002718
OpenTargets
ENSG00000012048
ZINC - Substances
BRCA1_HUMAN
ZINC target
P38398
PRO
P38398
PDB
1JM7
,
1N5O
,
1JNX
,
3PXC
,
4IFI
,
1T2U
,
1T2V
,
3K0H
,
3PXD
,
4Y2G
,
6G2I
,
3K0K
,
1Y98
,
7JZV
,
3PXE
,
4OFB
,
1OQA
,
4JLU
,
4Y18
,
3K15
,
1T29
,
7LYB
,
3K16
,
4U4A
,
4IGK
,
3PXB
,
8GRQ
,
3COJ
,
1T15
,
3PXA
,
2ING
GeneCards
P38398
HPA
ENSG00000012048-BRCA1
Ensembl
ENST00000491747
,
ENST00000493795
,
ENST00000461798
,
ENSP00000312236
,
ENST00000461221
,
ENST00000468300
,
ENSP00000420705
,
ENST00000352993
,
ENSP00000417148
,
ENSP00000418775
,
ENSG00000012048
,
ENSP00000417988
,
ENST00000357654
,
ENSP00000350283
,
ENSP00000418548
,
ENSP00000418960
,
ENST00000471181
Pharos - Targets
P38398
ZINC - Predictions - Purchasable
BRCA1_HUMAN
Orphanet
15377
Interactors (48)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BX63 BRIP1
2
p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(R-HSA-5687710)
BRIP1 [cytosol]
(R-HSA-2564781)
0.979
33
UniProt:Q99728 BARD1
13
BARD1 G623E [nucleoplasm]
(R-HSA-9699135)
BARD1 C71Y [nucleoplasm]
(R-HSA-9700808)
BARD1 C53W [nucleoplasm]
(R-HSA-9700807)
BARD1 G623W [nucleoplasm]
(R-HSA-9699148)
BARD1 W34R [nucleoplasm]
(R-HSA-9699166)
BARD1 H68Y [nucleoplasm]
(R-HSA-9699151)
BARD1 L44R [nucleoplasm]
(R-HSA-9699126)
BARD1 C50G [nucleoplasm]
(R-HSA-9699137)
BARD1 C83G [nucleoplasm]
(R-HSA-9699139)
K6PolyUb-BARD1 [nucleoplasm]
(R-HSA-9701024)
K6PolyUb,p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-9707286)
p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-5659846)
BARD1 [nucleoplasm]
(R-HSA-5659775)
0.958
20
UniProt:Q99708 RBBP8
4
p-S327,T847-RBBP8 [nucleoplasm]
(R-HSA-5684083)
RBBP8 [nucleoplasm]
(R-HSA-912399)
Ac-K-RBBP8 [nucleoplasm]
(R-HSA-5685955)
p-S327,T847,T859-RBBP8 [nucleoplasm]
(R-HSA-5684138)
0.935
15
UniProt:Q86YC2 PALB2
20
PALB2 Y28C [nucleoplasm]
(R-HSA-9724169)
PALB2 L35P [nucleoplasm]
(R-HSA-9724168)
PALB2 L24S [nucleoplasm]
(R-HSA-9724172)
PALB2 L21A [nucleoplasm]
(R-HSA-9704339)
PALB2 R37H [nucleoplasm]
(R-HSA-9724178)
PALB2 L21F [nucleoplasm]
(R-HSA-9704347)
PALB2 E12* [nucleoplasm]
(R-HSA-9704349)
PALB2 R37C [nucleoplasm]
(R-HSA-9724188)
PALB2 L35F [nucleoplasm]
(R-HSA-9704338)
PALB2 L947F [nucleoplasm]
(R-HSA-9724554)
PALB2 G1043D [nucleoplasm]
(R-HSA-9724584)
PALB2 T1030I [nucleoplasm]
(R-HSA-9704424)
PALB2 T841Qfs*10 [nucleoplasm]
(R-HSA-9704749)
PALB2 L1119P [nucleoplasm]
(R-HSA-9724589)
PALB2 L947S [nucleoplasm]
(R-HSA-9724557)
PALB2 L1143P [nucleoplasm]
(R-HSA-9704428)
PALB2 L1070P [nucleoplasm]
(R-HSA-9724556)
PALB2 C77Vfs*100 [nucleoplasm]
(R-HSA-9704738)
PALB2 L939W [nucleoplasm]
(R-HSA-9704417)
PALB2 L961P [nucleoplasm]
(R-HSA-9724583)
0.909
27
UniProt:Q6UWZ7 FAM175A
1
p-S406-FAM175A [nucleoplasm]
(R-HSA-5682575)
0.86
16
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.811
16
UniProt:Q96RL1 UIMC1
1
UIMC1 [nucleoplasm]
(R-HSA-5682574)
0.78
13
UniProt:O15360 FANCA
2
FANCA [nucleoplasm]
(R-HSA-419541)
FANCA [cytosol]
(R-HSA-420796)
0.747
5
UniProt:P51587 BRCA2
20
BRCA2 D2983Ffs*34 [cytosol]
(R-HSA-9709538)
BRCA2 K2555* [cytosol]
(R-HSA-9711337)
BRCA2 N2553Tfs*95 [cytosol]
(R-HSA-9712872)
BRCA2 T2685Hfs*9 [cytosol]
(R-HSA-9712879)
BRCA2 K2674Rfs*2 [cytosol]
(R-HSA-9712610)
BRCA2 S3231* [cytosol]
(R-HSA-9711458)
BRCA2 I2675Dfs*6 [cytosol]
(R-HSA-9712869)
BRCA2 R2625* [cytosol]
(R-HSA-9711482)
BRCA2 E3071* [cytosol]
(R-HSA-9711354)
BRCA2 V2716Wfs*17 [cytosol]
(R-HSA-9712761)
BRCA2 W2586* [cytosol]
(R-HSA-9711487)
BRCA2 P2767Lfs*10 [cytosol]
(R-HSA-9712509)
BRCA2 K3032* [cytosol]
(R-HSA-9711485)
BRCA2 S2835* [cytosol]
(R-HSA-9711345)
BRCA2 Y3006* [cytosol]
(R-HSA-9711222)
BRCA2 L2926* [cytosol]
(R-HSA-9711348)
BRCA2 R3128* [cytosol]
(R-HSA-9711177)
BRCA2 E2599* [cytosol]
(R-HSA-9711304)
BRCA2 E2571* [cytosol]
(R-HSA-9711560)
BRCA2 Y2977* [cytosol]
(R-HSA-9711182)
0.727
8
UniProt:Q06609 RAD51
2
RAD51 [nucleoplasm]
(R-HSA-62637)
p-T309-RAD51 [nucleoplasm]
(R-HSA-5685231)
0.718
6
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.715
6
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.714
4
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
0.7
5
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.65
4
UniProt:P27694 RPA1
2
polySUMO2,3-K449,K577-RPA1 [nucleoplasm]
(R-HSA-4551644)
RPA1 [nucleoplasm]
(R-HSA-68461)
0.65
3
UniProt:Q14676 MDC1
6
monoSUMO1-K1840-MDC1 [nucleoplasm]
(R-HSA-4570546)
polySUMO2,3-K1840-MDC1 [nucleoplasm]
(R-HSA-4570473)
K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684074)
SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684061)
p-5T-MDC1 [nucleoplasm]
(R-HSA-75236)
MDC1 [nucleoplasm]
(R-HSA-75231)
0.629
4
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.615
3
UniProt:P46736 BRCC3
2
BRCC3 [nucleoplasm]
(R-HSA-5682577)
BRCC3 [cytosol]
(R-HSA-5691415)
0.615
3
UniProt:P78347 GTF2I
0.61
5
UniProt:Q8WX92 NELFB
3
NELFB [nucleoplasm]
(R-HSA-112427)
NELFB [cytosol]
(R-HSA-9603526)
NELFB [mitochondrial outer membrane]
(R-HSA-9603553)
0.602
5
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.602
3
UniProt:Q6PJG6 BRAT1
0.602
6
UniProt:Q61188 Ezh2
1
Ezh2 [nucleoplasm]
(R-MMU-5617899)
0.591
5
UniProt:P61956 SUMO2
6
lysyl-G93-SUMO2 [cytosol]
(R-HSA-9834803)
SUMO2(1-95) [nucleoplasm]
(R-HSA-2990837)
UBA2-G93-SUMO2 [nucleoplasm]
(R-HSA-3730618)
SUMO2 [nucleoplasm]
(R-HSA-2984281)
UBE2I-G93-SUMO2 [nucleoplasm]
(R-HSA-3730625)
lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm]
(R-HSA-9761546)
0.589
2
UniProt:Q86YA3 ZGRF1
0.584
4
UniProt:Q9BXW9 FANCD2
3
MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6785318)
p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6788481)
FANCD2 [nucleoplasm]
(R-HSA-419522)
0.583
3
UniProt:Q9GZX5 ZNF350
1
ZNF350 [nucleoplasm]
(R-HSA-1247526)
0.581
3
UniProt:P62140 PPP1CB
4
PPP1CB [cytosol]
(R-HSA-163405)
PPP1CB [nucleoplasm]
(R-HSA-62003)
PPP1CB P49R [cytosol]
(R-HSA-9660547)
PPP1CB A56P [cytosol]
(R-HSA-9660543)
0.581
3
UniProt:Q16666 IFI16
1
IFI16 [cytosol]
(R-HSA-1834934)
0.556
9
UniProt:P03126 VE6
0.544
7
UniProt:P03129 VE7
0.544
5
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.544
2
UniProt:Q92560 BAP1
1
BAP1 [nucleoplasm]
(R-HSA-5689665)
0.543
3
UniProt:Q13085 ACACA
2
ACACA [cytosol]
(R-HSA-1660609)
Btn-ACACA [cytosol]
(R-HSA-2976730)
0.524
2
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.524
2
UniProt:Q6NZY4 ZCCHC8
1
ZCCHC8 [nucleoplasm]
(R-HSA-8985573)
0.524
2
UniProt:P11388 TOP2A
3
TOP2A [nucleoplasm]
(R-HSA-1362276)
polySUMO2,3-TOP2A [nucleoplasm]
(R-HSA-4641298)
monoSUMO1-K-TOP2A [nucleoplasm]
(R-HSA-4641367)
0.524
3
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.524
2
UniProt:P10809 HSPD1
6
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
0.508
2
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.508
3
UniProt:Q7Z569 BRAP
2
ub-BRAP [cytosol]
(R-HSA-5674001)
BRAP [cytosol]
(R-HSA-5672938)
0.508
3
UniProt:O75330 HMMR
2
HMMR [plasma membrane]
(R-HSA-2160885)
HMMR [cytosol]
(R-HSA-8861624)
0.499
4
UniProt:Q96SB3 NEB2
0.499
4
UniProt:Q9ULW0 TPX2
2
TPX2 [cytosol]
(R-HSA-8853407)
TPX2 [nucleoplasm]
(R-HSA-2564700)
0.483
4
UniProt:Q9NWV8 BABAM1
2
BABAM1 [nucleoplasm]
(R-HSA-5682582)
BABAM1 [cytosol]
(R-HSA-5691418)
0.483
2
UniProt:Q9NXR7 BRE
2
BRE [cytosol]
(R-HSA-5691413)
BRE [nucleoplasm]
(R-HSA-5682579)
0.483
2
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
0.463
3
UniProt:O14757 CHEK1
3
CHEK1 [cytosol]
(R-HSA-205285)
CHEK1 [nucleoplasm]
(R-HSA-113826)
p-S317,S345-CHEK1 [nucleoplasm]
(R-HSA-113838)
0.463
3
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