SPTBN1(2-159)-p-6Y-FLT3(570-993) fusion [cytosol]

Stable Identifier
R-HSA-9703317
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Spectrin beta chain, non-erythrocytic 1, SPTB2_HUMAN
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
17764812 A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy

Grand, FH, Zhang, L, Russell, NH, Cross, NC, Chase, A, Iqbal, S

2007
External Reference Information
External Reference
UniProt:Q01082 SPTBN1
Gene Names
SPTBN1, SPTB2
Chain
initiator methionine:, chain:2-2364
Reference Genes
BioGPS Gene:6711 SPTBN1
COSMIC (genes):SPTBN1 SPTBN1
CTD Gene:6711 SPTBN1
dbSNP Gene:6711 SPTBN1
ENSEMBL:ENSG00000115306 SPTBN1
HGNC:11275 SPTBN1
KEGG:hsa:6711 SPTBN1
Monarch:6711 SPTBN1
NCBI Gene:6711 SPTBN1
OMIM:182790 SPTBN1
UCSC:Q01082 SPTBN1
Reference Transcript
Other Identifiers
11716418_a_at
11716419_at
11716420_s_at
11716421_at
11716422_x_at
11716423_a_at
11722689_a_at
11722690_at
11758629_s_at
16880122
16880168
200671_PM_s_at
200671_s_at
200672_PM_x_at
200672_x_at
207283_3p_at
207283_PM_at
207283_at
212071_PM_s_at
212071_s_at
215918_PM_s_at
215918_s_at
226342_PM_at
226342_at
230540_PM_at
230540_at
242220_PM_at
242220_at
2482506
2482507
2482508
2482511
2482512
2482513
2482527
2482528
2482529
2482530
2482542
2482547
2482549
2482550
2482551
2482554
2482555
2482556
2482557
2482558
2482559
2482560
2482563
2482564
2482566
2482568
2482573
2482577
2482578
2482581
2482582
2482584
2482585
2482586
2482587
2482588
2482589
2482590
2482591
2482592
2482593
2482594
2482597
2482598
2482600
2482601
2482602
2482603
2482604
2482605
2482606
2482607
2482608
2482609
2482610
2482611
2482612
2482613
2482614
2482615
2482616
2482618
2482620
2482621
2482622
2482623
2482624
2482625
2482684
2482685
2482686
2482687
2482688
2482689
2482691
2947984
3161490
3482180
39452_s_at
39556_at
45202_at
52616_at
53241_at
58823_s_at
6711
73102_at
74748_s_at
8041995
8042038
81959_at
90584_at
A_14_P121454
A_14_P129691
A_14_P201367
A_23_P102523
A_23_P108932
A_23_P339095
A_33_P3258467
A_33_P3258472
GE55162
GE567749
GE58172
GE84893
GE877747
GE88335
GO:0000281
GO:0000910
GO:0003723
GO:0003779
GO:0005198
GO:0005200
GO:0005515
GO:0005516
GO:0005543
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0007009
GO:0007010
GO:0007417
GO:0008091
GO:0008092
GO:0008289
GO:0014069
GO:0014731
GO:0016020
GO:0016192
GO:0021556
GO:0030036
GO:0030054
GO:0030506
GO:0030673
GO:0030863
GO:0030864
GO:0031430
GO:0032437
GO:0032743
GO:0032991
GO:0042995
GO:0043001
GO:0043226
GO:0044877
GO:0045296
GO:0048856
GO:0051015
GO:0051020
GO:0051693
GO:0060390
GO:0061024
GO:0070062
GO:0071709
GO:0072659
GO:0098794
GO:0098978
GO:1903076
GO:1903078
HMNXSV003003918
HMNXSV003013564
HMNXSV003023445
Hs.107164.0.S1_3p_a_at
Hs.107164.4.S1_3p_a_at
Hs.107164.4.S1_3p_at
Hs.155033.0.A1_3p_at
Hs.236443.0.S1_3p_at
Hs.27286.0.A1_3p_at
Hs.324648.0.S1_3p_at
ILMN_1661335
ILMN_1690708
ILMN_1714228
ILMN_1752897
ILMN_2124757
M96803_at
PH_hs_0023033
PH_hs_0034880
TC02000315.hg
TC02000316.hg
TC02000317.hg
TC02003238.hg
TC02003239.hg
TC02003240.hg
g4507194_3p_s_at
g9910199_3p_at
g9910199_3p_x_at
p33962
Participates
as a component of
Other forms of this molecule
SPTBN1(2-159)-FLT3(570-993) fusion [cytosol]
SPTBN1 [cytosol]
Modified Residues
Name
Insertion of residues 570 to 993 at 160 from UniProt:P36888 FLT3
Coordinate
160
Name
O4'-phospho-L-tyrosine at 589
Coordinate
589
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 591
Coordinate
591
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 599
Coordinate
599
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 768
Coordinate
768
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 955
Coordinate
955
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 969
Coordinate
969
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
chronic myeloid leukemia DOID:8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
Cross References
RefSeq
ENSEMBL
OpenTargets
HPA
PRO
Pharos - Targets
GlyGen
HMDB Protein
PDB
Interactors (3)
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