STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants

Stable Identifier
R-HSA-9703436
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants
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PIM1 is a serine threonine kinase with roles in cellular proliferation, survival and escape from apoptosis. Its expression is upregulated in a number of hematological cancers (reviewed in Arrouchi et al, 2019; Zhang et al, 2018). PIM1 expression is upregulated in BaF3 cells expressing constitutively activated STAT5, and STAT5-mediated upregulation of PIM1 has been shown downstream of FLT ITD and ETV6-FLT3 fusion mutants (Nosaka et al, 1999; Kim et al, 2005; Vu et al, 2009; Okada et al, 2018).
Literature References
PubMed ID Title Journal Year
15498859 Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

Levis, M, Ahn, JY, Small, D, Lilly, M, Kim, KT, Meltzer, P, Baird, K

Blood 2005
30370255 PIM Kinase as an Executional Target in Cancer

Song, M, Lee, MH, Liu, ZZ, Kundu, JK, Zhang, X

2018
19345670 The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation

Xinh, PT, Vu, HA, Kano, Y, Tokunaga, K, Sato, Y

2009
10469654 STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

Mui, AL, Kitamura, T, Ikuta, K, Misawa, K, Nosaka, T, Kawashima, T

1999
31359998 A review on PIM kinases in tumors

Lakhlili, W, Ibrahimi, A, Arrouchi, H

2019
29507660 FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway

Okada, K, Akiyama, H, Miura, O, Ishida, S, Umezawa, Y, Chen, C, Nogami, A

2018
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-STAT5 [nucleoplasm] (Homo sapiens)
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-10-06)
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