SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed

Stable Identifier
R-HSA-9705726
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, endocytic vesicle membrane
ReviewStatus
5/5
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SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
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After binding CSF3 (G-CSF), the CSF3 receptor CSF3R is internalized into endosomes (Aarts et al. 2004). Only a minor portion of CSF3R is located at the plasma membrane. Most CSF3R is located internally in the Golgi, endosomes, and lysosomes (Aarts et al. 2004). Endocytosis depends on a dileucine motif in the C-terminal region of CSF3R (inferred from mouse homologs).
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Inferred From
Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed (Mus musculus)
Authored
May, B  (2020-10-24)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-10-30)
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