Reactome | SLA [cytosol]

SLA [cytosol]

Stable Identifier

R-HSA-9706158

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Src-like-adapter, SLAP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13239 SLA

Gene Names

SLA, SLAP, SLAP1

Chain

initiator methionine:1, chain:2-276

Reference Genes

BioGPS Gene:6503 SLA

COSMIC (genes):SLA SLA

CTD Gene:6503 SLA

dbSNP Gene:6503 SLA

ENSEMBL:ENSG00000155926 SLA

ENSEMBL:ENSG00000155926.14 SLA

HGNC:10902 SLA

KEGG Gene (Homo sapiens):6503 SLA

Monarch:6503 SLA

NCBI Gene:6503 SLA

OMIM:601099 SLA

UCSC:Q13239 SLA

Reference Transcript

Other Identifiers

11720300_a_at

11720301_a_at

11720302_a_at

11758830_at

1426_at

1427_g_at

203760_PM_s_at

203760_s_at

203761_PM_at

203761_at

3154262

3154264

3154265

3154266

3154267

3154269

3154277

3154278

3154280

3154282

3154283

3154286

3154287

3154288

3154297

3154303

58130_at

6503

8152988

A_23_P216340

A_24_P239578

D89077_at

GE57435

GO:0001784

GO:0005154

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0007165

GO:0008180

GO:0023052

GO:0031410

GO:0043226

GO:0043408

HMNXSV003037401

ILMN_2291954

ILMN_2345898

PH_hs_0004322

PH_hs_0031319

g1809245_3p_a_at

g5803170_3p_at

Participates

as an input of

Active FLT3 binds to SLA (Homo sapiens)

as a component of

active FLT3:SLA [plasma membrane] (Homo sapiens)

Inferred To

Sla [cytosol] (Mus musculus)

Sla [cytosol] (Rattus norvegicus)

SLA [cytosol] (Bos taurus)

SLA [cytosol] (Canis familiaris)

SLA [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001269894.1, XP_016869228.1, NP_001039021.1, NP_006739.2, NP_001269893.1, NP_001039022.2

OpenTargets

ENSG00000155926

HPA

ENSG00000155926-SLA

GeneCards

Q13239

Ensembl

ENSP00000337548, ENST00000524345, ENST00000395352, ENSP00000428559, ENSP00000394049, ENSG00000155926, ENSP00000427928, ENSP00000378759, ENST00000517648, ENST00000338087, ENST00000427060

PRO

Q13239

Pharos - Targets

Q13239

PDB

2CUD

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.692	3
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.462	4

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