Reactome | SLA [cytosol]

SLA [cytosol]

Stable Identifier

R-HSA-9706158

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Src-like-adapter, SLAP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13239 SLA

Gene Names

SLA, SLAP, SLAP1

Chain

initiator methionine:, chain:2-276

Reference Genes

COSMIC (genes):SLA Q132393

dbSNP Gene:6503 Q132393

ENSEMBL:ENSG00000155926 SLA

Participates

as an input of

Active FLT3 binds to SLA (Homo sapiens)

as a component of

active FLT3:SLA [plasma membrane] (Homo sapiens)

Inferred To

Sla [cytosol] (Mus musculus)

SLA [cytosol] (Bos taurus)

SLA [cytosol] (Canis familiaris)

SLA [cytosol] (Sus scrofa)

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.692	3
UniProt:Q15596 NCOA2	3	NCOA2 [nucleoplasm] (R-HSA-376398) NCOA2 (869-1464) [nucleoplasm] (R-HSA-5603186) monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm] (R-HSA-4085305)	0.589	2
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.462	4

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