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p-Y GRB10 [cytosol]
Stable Identifier
R-HSA-9706168
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Growth factor receptor-bound protein 10, GRB10 adaptor protein, Insulin receptor binding protein GRB-IR
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Homo sapiens)
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Homo sapiens)
p-Y GRB10 [cytosol] (Homo sapiens)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Homo sapiens)
p-Y GRB10 [cytosol] (Homo sapiens)
Active FLT3:p-Y-GRB10 binds PIK3R1 (Homo sapiens)
active FLT3:p-Y GRB10 [plasma membrane] (Homo sapiens)
p-Y GRB10 [cytosol] (Homo sapiens)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Homo sapiens)
p-Y GRB10 [cytosol] (Homo sapiens)
FLT3 phosphorylates GRB10 (Homo sapiens)
active FLT3:p-Y GRB10 [plasma membrane] (Homo sapiens)
p-Y GRB10 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13322 GRB10
Gene Names
GRB10, GRBIR, KIAA0207
Chain
chain:1-594
Reference Genes
BioGPS Gene:2887 GRB10
COSMIC (genes):GRB10 GRB10
CTD Gene:2887 GRB10
dbSNP Gene:2887 GRB10
ENSEMBL:ENSG00000106070 GRB10
HGNC:4564 GRB10
KEGG:hsa:2887 GRB10
Monarch:2887 GRB10
NCBI Gene:2887 GRB10
OMIM:601523 GRB10
UCSC:Q13322 GRB10
Reference Transcript
RefSeq:XM_011515312.2 GRB10
RefSeq:NM_005311.4 GRB10
RefSeq:XM_054357967.1 GRB10
RefSeq:XM_047420252.1 GRB10
RefSeq:NM_001001550.3 GRB10
RefSeq:XM_017012066.1 GRB10
RefSeq:NM_001001555.3 GRB10
RefSeq:XM_017012046.1 GRB10
RefSeq:XM_017012068.1 GRB10
RefSeq:XM_047420253.1 GRB10
RefSeq:XM_011515304.1 GRB10
RefSeq:XM_054357963.1 GRB10
RefSeq:XM_054357981.1 GRB10
RefSeq:XM_054357980.1 GRB10
RefSeq:XM_017012067.1 GRB10
RefSeq:XM_054357979.1 GRB10
RefSeq:XM_047420254.1 GRB10
RefSeq:XM_017012065.1 GRB10
RefSeq:XM_017012063.1 GRB10
RefSeq:XM_054357964.1 GRB10
RefSeq:XM_047420243.1 GRB10
RefSeq:XM_047420241.1 GRB10
RefSeq:XM_047420244.1 GRB10
RefSeq:NM_001001549.3 GRB10
RefSeq:XM_054357966.1 GRB10
RefSeq:XM_017012045.1 GRB10
RefSeq:XM_011515316.1 GRB10
RefSeq:NM_001350814.2 GRB10
RefSeq:NM_001371008.1 GRB10
RefSeq:XM_047420255.1 GRB10
RefSeq:XM_017012064.1 GRB10
RefSeq:NM_001350816.3 GRB10
Participates
as a component of
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Homo sapiens)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Homo sapiens)
active FLT3:p-Y GRB10 [plasma membrane] (Homo sapiens)
Other forms of this molecule
GRB10 [cytosol]
Inferred To
phospho-grb10 [cytosol]
(Xenopus tropicalis)
phospho-Grb10 [cytosol]
(Mus musculus)
phospho-Grb10 [cytosol]
(Rattus norvegicus)
phospho-Grb10 [cytosol]
(Sus scrofa)
phospho-GRB10 [cytosol]
(Bos taurus)
phospho-GRB10 [cytosol]
(Canis familiaris)
phospho-GRB10 [cytosol]
(Gallus gallus)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001337745.2
,
NP_001337743.1
,
XP_047276211.1
,
XP_011513618.1
,
NP_001001555.1
,
NP_001357937.1
,
NP_001001550.1
,
XP_054213954.1
,
XP_011513614.1
,
XP_047276200.1
,
XP_047276208.1
,
XP_011513606.1
,
XP_047276209.1
,
XP_047276210.1
,
NP_001001549.1
,
XP_016867553.1
,
XP_016867552.1
,
XP_016867534.1
,
NP_005302.3
,
XP_016867557.1
,
XP_054213942.1
,
XP_054213941.1
,
XP_054213939.1
,
XP_016867535.1
,
XP_016867554.1
,
XP_016867556.1
,
XP_047276199.1
,
XP_016867555.1
,
XP_054213938.1
,
XP_054213955.1
,
XP_047276197.1
,
XP_054213956.1
OpenTargets
ENSG00000106070
ENSEMBL
ENST00000406641
,
ENST00000403097
,
ENSP00000385748
,
ENSG00000106070
,
ENSP00000496245
,
ENST00000335866
,
ENST00000357271
,
ENSP00000385189
,
ENST00000401949
,
ENSP00000385366
,
ENSP00000385046
,
ENSP00000385544
,
ENST00000645075
,
ENSP00000381793
,
ENST00000643299
,
ENST00000402497
,
ENST00000407526
,
ENST00000402578
,
ENSP00000338543
,
ENSP00000385770
,
ENSP00000349818
,
ENSP00000495341
,
ENSP00000381790
,
ENST00000398812
,
ENST00000398810
GeneCards
GRB10
HPA
ENSG00000106070-GRB10
PRO
Q13322
Pharos - Targets
Q13322
GlyGen
Q13322
PDB
3HK0
,
1NRV
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.729
4
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.643
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.643
4
UniProt:P36888 FLT3
20
FLT3 F691I [plasma membrane]
(R-HSA-9702900)
FLT3 N676D [plasma membrane]
(R-HSA-9702895)
FLT3 R834Q [plasma membrane]
(R-HSA-9691899)
FLT3 Y572C [plasma membrane]
(R-HSA-9691902)
FLT3 A848P [plasma membrane]
(R-HSA-9702909)
FLT3 A627P [plasma membrane]
(R-HSA-9699448)
FLT3 F621L [plasma membrane]
(R-HSA-9699426)
p-Y768,Y969 FLT3 [plasma membrane]
(R-HSA-9698405)
Ub-pY FLT3 [endosome membrane]
(R-HSA-9706174)
Ub-pY FLT3 [plasma membrane]
(R-HSA-9706171)
FLT3 V592G [plasma membrane]
(R-HSA-9691071)
FLT3 F590_F605dup [plasma membrane]
(R-HSA-9697939)
FLT3 F590G Y591D [plasma membrane]
(R-HSA-9691062)
FLT3 F594L [plasma membrane]
(R-HSA-9691058)
FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
(R-HSA-9699433)
FLT3 V579A [plasma membrane]
(R-HSA-9691051)
FLT3 Y599_D600insGLYVDFREYEY [plasma membrane]
(R-HSA-9696044)
FLT3 Y591_V592insVDFREDREHH [plasma membrane]
(R-HSA-9696043)
FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane]
(R-HSA-9690076)
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane]
(R-HSA-9696033)
0.591
6
UniProt:P06213 INSR
6
INSR(28-758) [plasma membrane]
(R-HSA-74668)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
0.581
4
UniProt:Q9UKA8 RCAN3
1
RCAN3 [cytosol]
(R-HSA-9728800)
0.57
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.564
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.564
2
UniProt:Q66LE6 PPP2R2D
1
PPP2R2D [nucleoplasm]
(R-HSA-2160962)
0.527
3
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.527
2
UniProt:P54762 EPHB1
6
p-Y594,Y600-EPHB1 [plasma membrane]
(R-HSA-3928347)
EPHB1 [plasma membrane]
(R-HSA-2682340)
EPHB1 (18-?) [extracellular region]
(R-HSA-3928393)
EPHB1 (?-984) [plasma membrane]
(R-HSA-3928402)
EPHB1 (?-984) [cytosol]
(R-HSA-3928438)
EPHB1 (?-?) [plasma membrane]
(R-HSA-3928449)
0.499
2
UniProt:Q9UQB8-6 BAIAP2
0.488
2
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