Active FLT3 binds to LCK

Stable Identifier
R-HSA-9706312
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Active FLT3 binds to LCK
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SRC family of non-receptor tyrosine kinase LCK binds to tyrosine-phosphorylated FLT3. LCK-binding stimulates STAT signaling downstream of FLT3-ITD mutants and promotes cellular proliferation and tumor formation in mouse models (Marhall et al, 2017).
Literature References
PubMed ID Title Journal Year
29062038 The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation

Kazi, JU, Rönnstrand, L, Marhäll, A

Sci Rep 2017
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Orthologous Events
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Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-11-04)
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