Internalization of ubiquitinated FLT3

Stable Identifier
R-HSA-9706364
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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E3 ligase- mediated ubiquitination of FLT3 leads to its internalization to the endosomal compartment (Sargin et al, 2007; Reindl et al, 2009; reviewed in Kazi and Ronnstrand, 2019).
Literature References
PubMed ID Title Journal Year
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
19276253 CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes

Buske, C, Duyster, J, Reindl, C, Spiekermann, K, Vempati, S, Bohlander, SK, Humphries, KR, Greif, PA, Mellert, G, Argiropoulos, B, Hiddemann, W, Quentmeier, H, Benthaus, T, Petropoulos, K

Clin Cancer Res 2009
17446348 Flt3-dependent transformation by inactivating c-Cbl mutations in AML

Berdel, WE, Grundler, R, Serve, H, Duyster, J, Brandts, C, Tickenbrock, L, Choudhary, C, Koschmieder, S, Dikic, I, Müller-Tidow, C, Schwäble, J, August, B, Thiessen, C, Crosetto, N, Sargin, B, Rensinghoff, M, Bandi, SR, Schmidt, MHH

Blood 2007
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