Negative regulation of FLT3

Stable Identifier
R-HSA-9706369
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

FLT3 activity is negatively regulated through several mechanisms including dephosphorylation, interaction with protein partners that limit downstream signaling pathways, and by ubiquitin-mediated internalization and degradation (reviewed in Kazi and Roonstrand, 2019).

Literature References
PubMed ID Title Journal Year
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!