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UBXN1 binds BRCA1:BARD1 heterodimer
Stable Identifier
R-HSA-9707051
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
UBXN1 binds BRCA1:BARD1 heterodimer (Homo sapiens)
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The UBXN1 polypeptide can bind to and suppress the E3 ligase activity of autoubiquitinated BRCA1/BARD1 heterodimers. UBXN1 recognizes autoubiquitinated heterodimers through a bipartite interaction in which its UBA domain binds the conjugated K6-linked polyubiquitin chains of BRCA1:BARD1 while its C-terminal region binds BRCA1:BARD1 in a ubiquitin-independent manner.
Literature References
PubMed ID
Title
Journal
Year
20351172
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function
Baer, R
,
Ludwig, T
,
Wu-Baer, F
Mol Cell Biol
2010
Participants
Input
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm]
(Homo sapiens)
UBXN1 [nucleoplasm]
(Homo sapiens)
Output
UBXN1:K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
Orthologous Events
UBXN1 binds BRCA1:BARD1 heterodimer (Bos taurus)
UBXN1 binds BRCA1:BARD1 heterodimer (Canis familiaris)
UBXN1 binds BRCA1:BARD1 heterodimer (Mus musculus)
UBXN1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)
UBXN1 binds BRCA1:BARD1 heterodimer (Sus scrofa)
Authored
Baer, RJ (2020-11-04)
Created
Orlic-Milacic, M (2020-11-10)
© 2024
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