UBXN1 binds BRCA1:BARD1 heterodimer

Stable Identifier
R-HSA-9707051
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The UBXN1 polypeptide can bind to and suppress the E3 ligase activity of autoubiquitinated BRCA1/BARD1 heterodimers. UBXN1 recognizes autoubiquitinated heterodimers through a bipartite interaction in which its UBA domain binds the conjugated K6-linked polyubiquitin chains of BRCA1:BARD1 while its C-terminal region binds BRCA1:BARD1 in a ubiquitin-independent manner.

Literature References
PubMed ID Title Journal Year
20351172 The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function

Wu-Baer, F, Ludwig, T, Baer, R

Mol Cell Biol 2010
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