Reactome | Hemes bind to BACH1:MAFK

Hemes bind to BACH1:MAFK

Stable Identifier

R-HSA-9707523

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Heme binds to four cysteine-proline motifs in the C-terminal region of BACH1 and inhibits the DNA-binding activity of BACH1-MAFK heterodimers resulting in HMOX1 induction. MAFK separates from the complex, and heme recruits nuclear exporters for BACH1 (Yoshida et al, 1988; Ogawa et al, 2001; Suzuki et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
11387216	Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1 Nishitani, C, Sassa, S, Nakajima, O, Taketani, S, Shibahara, S, Yamamoto, M, Hayashi, N, Igarashi, K, Sun, J, Fujita, H, Ogawa, K	EMBO J	2001
3345742	Human heme oxygenase cDNA and induction of its mRNA by hemin Yoshida, T, Müller, RM, Biro, P, Shibahara, S, Cohen, T	Eur J Biochem	1988
15175654	Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1 Sun, J, Hira, S, Yamazaki, C, Yoshida, M, Igarashi, K, Ikeda-Saito, M, Suzuki, H, Zenke, Y, Tashiro, S	EMBO J	2004