Reactome | PGRMC2 [nuclear envelope]

PGRMC2 [nuclear envelope]

Stable Identifier

R-HSA-9707674

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Locations in the PathwayBrowser for interactor UniProt:I3L0A0 I3L0A0

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External Reference Information

External Reference

UniProt:O15173 PGRMC2

Gene Names

PGRMC2, DG6, PMBP

Chain

chain:1-223

Reference Genes

BioGPS Gene:10424 PGRMC2

COSMIC (genes):PGRMC2 PGRMC2

CTD Gene:10424 PGRMC2

dbSNP Gene:10424 PGRMC2

ENSEMBL:ENSG00000164040 PGRMC2

HGNC:16089 PGRMC2

KEGG:hsa:10424 PGRMC2

Monarch:10424 PGRMC2

NCBI Gene:10424 PGRMC2

OMIM:607735 PGRMC2

UCSC:O15173 PGRMC2

Reference Transcript

RefSeq:NM_006320.4 PGRMC2

Other Identifiers

10424

11715920_a_at

11758737_s_at

16979698

201701_PM_s_at

201701_s_at

213227_PM_at

213227_at

2785113

2785115

2785116

2785117

2785118

2785119

2785120

2785121

2785122

2785123

2785124

2785125

2785132

2785133

2785134

2785135

2785136

2785137

2785138

2785139

2785140

2785141

2785142

2785143

2785144

2785145

38821_at

8102745

A_23_P155868

A_24_P405850

GE522759

GE55150

GO:0003707

GO:0005215

GO:0005496

GO:0005515

GO:0005576

GO:0005634

GO:0005635

GO:0005654

GO:0005783

GO:0008289

GO:0012505

GO:0015232

GO:0015886

GO:0016020

GO:0020037

GO:0043226

GO:0043401

GO:0045202

GO:0048856

GO:0060089

GO:0060612

GO:0098978

GO:0140110

HMNXSV003028066

Hs.9071.1.A1_3p_at

ILMN_2195236

PH_hs_0000958

TC04001537.hg

g5453915_3p_a_at

Participates

as a component of

PGRMC2:Hemes [nuclear envelope] (Homo sapiens)

as an input of

PGRMC2 binds Hemes (Homo sapiens)

Other forms of this molecule

PGRMC2 [nucleoplasm]

PGRMC2 [endoplasmic reticulum membrane]

PGRMC2 [endosome membrane]

Inferred To

DAP1 [nuclear envelope] (Saccharomyces cerevisiae)

Pgrmc2 [nuclear envelope] (Mus musculus)

Pgrmc2 [nuclear envelope] (Rattus norvegicus)

pgrmc2 [nuclear envelope] (Danio rerio)

MSBP [nuclear envelope] (Drosophila melanogaster)

vem-1 [nuclear envelope] (Caenorhabditis elegans)

PGRMC2 [nuclear envelope] (Bos taurus)

PGRMC2 [nuclear envelope] (Canis familiaris)

PGRMC2 [nuclear envelope] (Dictyostelium discoideum)

PGRMC2 [nuclear envelope] (Gallus gallus)

PGRMC2 [nuclear envelope] (Schizosaccharomyces pombe)

PGRMC2 [nuclear envelope] (Sus scrofa)

Cross References

OpenTargets

ENSG00000164040

ENSEMBL

ENST00000296425, ENSP00000429301, ENSP00000296425, ENST00000613358, ENSP00000481886, ENST00000520121

HPA

ENSG00000164040-PGRMC2

PRO

O15173

Pharos - Targets

O15173

GlyGen

O15173

HMDB Protein

HMDBP08665

Interactors (62)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00264 PGRMC1	2	PGRMC1 [plasma membrane] (R-HSA-6806314) PGRMC1 [specific granule membrane] (R-HSA-6799648)	0.666	4
UniProt:Q8IWB1 IPRI			0.666	4
UniProt:Q9P0L0 VAPA	4	VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920)	0.666	5
UniProt:Q9NWU2 GID8	1	GID8 [cytosol] (R-HSA-9861665)	0.638	3
UniProt:Q9Y4C4 MFHA1			0.59	2
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	4
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:Q5RI15 COX20	1	COX20 [mitochondrial inner membrane] (R-HSA-5336169)	0.556	3
UniProt:Q13021 MALL			0.556	3
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.556	3
UniProt:O60636 TSN2			0.556	3
UniProt:Q96HH6 TMM19			0.556	3
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:Q9UBY5 LPAR3	1	LPAR3 [plasma membrane] (R-HSA-419379)	0.556	3
UniProt:P78329 CYP4F2	1	CYP4F2 [endoplasmic reticulum membrane] (R-HSA-211016)	0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	5
UniProt:Q9H0Q3 FXYD6	1	FXYD6 [plasma membrane] (R-HSA-2752104)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q86UD5 SLC9B2	1	SLC9B2 [mitochondrial inner membrane] (R-HSA-2889045)	0.556	3
UniProt:Q6N075 MFSD5			0.556	3
UniProt:O00124 UBXN8			0.556	3
UniProt:Q9H3K2 GHITM			0.556	3
UniProt:O43681 GET3	1	ASNA1 [cytosol] (R-HSA-9609520)	0.556	3
UniProt:Q7RTY0 MOT13			0.556	3
UniProt:Q14656 TM187			0.556	3
UniProt:Q8N2M4 TM86A			0.556	3
UniProt:Q9BWQ6 YIPF2			0.556	3
UniProt:Q96H72 S39AD			0.556	3
UniProt:Q9P0S3 ORMDL1	1	ORMDL1 [endoplasmic reticulum membrane] (R-HSA-8865584)	0.556	3
UniProt:Q96IV6 FXDC2			0.556	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:P02787 TF	6	TF [endoplasmic reticulum lumen] (R-HSA-8956763) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) apoTF [endosome membrane] (R-HSA-917974) apoTF [extracellular region] (R-HSA-350754) TF [secretory granule lumen] (R-HSA-350704) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140)	0.556	3
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:O95159 ZFPL1			0.556	3
IntAct:EBI-23343277 CCSB ORF ID			0.556	3
UniProt:Q96GQ5 RUSF1			0.556	3
UniProt:Q9BTX3 TM208			0.556	3
UniProt:Q96PS8 AQP10	1	AQP10 [plasma membrane] (R-HSA-431709)	0.556	3
UniProt:Q96JF0-2 ST6GAL2			0.556	3
UniProt:P59542 TAS2R19	1	TAS2R19 [plasma membrane] (R-HSA-3299625)	0.556	3
UniProt:Q9Y342 PLLP			0.556	3
UniProt:Q9Y5Y5 PEX16	2	PEX16 [peroxisomal membrane] (R-HSA-9603805) PEX16 [cytosol] (R-HSA-9603790)	0.556	3
UniProt:I3L0A0 I3L0A0			0.556	3
UniProt:Q8TDV0 GP151			0.556	3
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.556	3
UniProt:Q6UX40 TM107			0.556	3
UniProt:P11215 ITGAM	3	ITGAM [plasma membrane] (R-HSA-202757) ITGAM [specific granule membrane] (R-HSA-6799647) ITGAM [tertiary granule membrane] (R-HSA-6800979)	0.556	3
IntAct:EBI-23194662 CCSB ORF ID			0.556	3
UniProt:Q96L15 NAR5			0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:Q9H9B4 SFXN1			0.556	3
UniProt:Q8IVQ6 ZDHHC21	1	ZDHHC21 [Golgi membrane] (R-HSA-203757)	0.556	3
UniProt:O14569 C56D2			0.556	3
UniProt:P01031 C5	7	C5a [extracellular region] (R-HSA-173677) C5 beta chain [extracellular region] (R-HSA-173675) C5 alpha chain [extracellular region] (R-HSA-173673) C5b alpha' [extracellular region] (R-HSA-173672) C5a-desArg [extracellular region] (R-HSA-8852798) C5aT [extracellular region] (R-HSA-8852711) C5(965-1676) [extracellular region] (R-HSA-8852713)	0.556	3
UniProt:Q8N5I4 DHRSX			0.556	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.556	3
UniProt:O14681 EI24			0.556	3
UniProt:O60906 SMPD2	1	SMPD2 [plasma membrane] (R-HSA-194337)	0.556	3
UniProt:Q96G75 RMND5B	1	RMND5B [cytosol] (R-HSA-9861550)	0.508	2
UniProt:P22315	1	FECH [mitochondrial inner membrane] (R-MMU-189441)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10

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