Reactome | PGRMC2:Hemes dissociates

PGRMC2:Hemes dissociates

Stable Identifier

R-HSA-9707856

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Free heme behaves differently in the nucleus, in the absence of PGRMC2. This implies that heme may separate from the PGRMC2:heme complex. The exact conditions under which dissociation might occur are unknown (Galmozzi et al, 2019).

Literature References

PubMed ID	Title	Journal	Year
31748741	PGRMC2 is an intracellular haem chaperone critical for adipocyte function Cintron-Colon, R, Mosure, S, Kojetin, D, Montenegro-Burke, JR, Godio, C, Siuzdak, G, Kim, AS, Webb, WR, Kok, BP, Cravatt, BF, Peluso, JJ, Conti, B, Lee, JY, Galmozzi, A, Solt, LA, Parker, CG, Pru, JK, Albert, V, Spreafico, R, Saez, E	Nature	2019