CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane

Stable Identifier
R-HSA-9707977
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endocytic vesicle membrane, lysosomal membrane
ReviewStatus
5/5
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CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
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Polyubiquitinated CSF3R, believed to be in a complex with with CSF3 and other signaling molecules, transits from endosomes to lysosomes (Aarts et al. 2004, Irandoust et al. 2007, Wölfler et al. 2009).
Literature References
PubMed ID Title Journal Year
14512302 Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kinetics

Aarts, LH, Roovers, O, Ward, AC, Touw, IP

Blood 2004
19453968 Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor

Wölfler, A, Irandoust, M, Meenhuis, A, Gits, J, Roovers, O, Touw, IP

Traffic 2009
17363902 Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor

Irandoust, MI, Aarts, LH, Roovers, O, Gits, J, Erkeland, SJ, Touw, IP

EMBO J 2007
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Orthologous Events
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Bos taurus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Canis familiaris)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Danio rerio)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Mus musculus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Rattus norvegicus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Sus scrofa)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Xenopus tropicalis)
Authored
May, B  (2020-11-09)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-11-21)
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