The leucine-rich repeat family of F-box proteins (FBXLs) function as adapter for the SKP1-CUL1-F-box protein (SCF) E3 ubiqitin ligase. FBXL17 is a regulator of the nuclear factor erythroid 2-related factor 2 (NFE2L2) oxidative stress pathway. By binding to the transcriptional repressor transcription regulator protein BACH1 it controls the transcription of the NFE2L2 target heme oxygenase 1 (HMOX1) via turnover of BACH1 in the absence or presence of extrinsic oxidative stress (Tan et al, 2013).
Tan, MK, Lim, HJ, Bennett, EJ, Shi, Y, Harper, JW
ubiquitin protein ligase activity of BACH1:FBXL17:SCF (SKP2) [nucleoplasm]
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