ATIC(1-230)-ALK(1059-1620) fusion [cytosol]

Stable Identifier
R-HSA-9710832
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Bifunctional purine biosynthesis protein ATIC, PUR9_HUMAN
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
10706082 A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma

Trinei, M, Lanfrancone, L, Campo, E, Pulford, K, Mason, DY, Pelicci, PG, Falini, B

Cancer Res 2000
10706887 Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis

Ma, Z, Cools, J, Marynen, P, Cui, X, Siebert, R, Gesk, S, Schlegelberger, B, Peeters, B, De Wolf-Peeters, C, Wlodarska, I, Morris, SW

Blood 2000
External Reference Information
External Reference
Gene Names
ATIC, PURH, OK/SW-cl.86
Chain
initiator methionine:1, chain:1-592, chain:2-592
Reference Transcript
Other Identifiers
0000840301
11715755_a_at
16890490
208758_at
2526766
2526767
2526768
2526769
2526770
2526771
2526772
2526776
2526777
2526779
2526780
2526782
2526783
2526784
2526785
2526786
2526787
2526788
2526793
2526795
2526801
2526802
2526803
2526804
38811_at
471
8048120
A_23_P68087
D82348_at
GE57324
GO:0003360
GO:0003674
GO:0003824
GO:0003937
GO:0004643
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0005886
GO:0006139
GO:0006164
GO:0006189
GO:0008150
GO:0008152
GO:0009058
GO:0009116
GO:0009168
GO:0009259
GO:0010035
GO:0016020
GO:0016740
GO:0016787
GO:0016810
GO:0021549
GO:0021987
GO:0031100
GO:0034641
GO:0042803
GO:0043226
GO:0044281
GO:0045296
GO:0046452
GO:0046654
GO:0048856
GO:0070062
GO:0098761
HMNXSV003041780
ILMN_1673991
PH_hs_0005040
TC02001260.hg
TC02003807.hg
g2317691_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 1059 to 1620 at 231 from UniProt:Q9UM73 ALK
Coordinate
231
Disease
Cross References
RefSeq
OpenTargets
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Metabolites
COSMIC
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (1)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P00533 EGFR  59 0.553 2
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