Reactome | ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol]

ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol]

Stable Identifier

R-HSA-9710833

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Bifunctional purine biosynthesis protein ATIC, PUR9_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
10706887	Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis Ma, Z, Cools, J, Marynen, P, Cui, X, Siebert, R, Gesk, S, Schlegelberger, B, Peeters, B, De Wolf-Peeters, C, Wlodarska, I, Morris, SW	Blood	2000
10706082	A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma Trinei, M, Lanfrancone, L, Campo, E, Pulford, K, Mason, DY, Pelicci, PG, Falini, B	Cancer Res	2000

External Reference Information

External Reference

UniProt:P31939 ATIC

Gene Names

ATIC, PURH, OK/SW-cl.86

Chain

chain:1-592, initiator methionine:1, chain:2-592

Reference Genes

BioGPS Gene:471 ATIC

COSMIC (genes):ATIC ATIC

CTD Gene:471 ATIC

dbSNP Gene:471 ATIC

ENSEMBL:ENSG00000138363 ATIC

HGNC:794 ATIC

KEGG:hsa:471 ATIC

Monarch:471 ATIC

NCBI Gene:471 ATIC

OMIM:601731 ATIC

UCSC:P31939 ATIC

Reference Transcript

RefSeq:NM_004044.6 ATIC

Other Identifiers

11715755_a_at

16890490

208758_PM_at

208758_at

2526766

2526767

2526768

2526769

2526770

2526771

2526772

2526776

2526777

2526778

2526779

2526780

2526781

2526782

2526783

2526784

2526785

2526786

2526787

2526788

2526793

2526794

2526795

2526796

2526797

2526798

2526799

2526800

2526801

2526802

2526803

2526804

2526805

3771131

38811_at

471

76913_at

8048120

A_14_P101313

A_14_P117158

A_23_P68087

D82348_at

GE57324

GO:0003360

GO:0003824

GO:0003937

GO:0004643

GO:0005737

GO:0005829

GO:0005886

GO:0006139

GO:0006164

GO:0006177

GO:0006189

GO:0006575

GO:0016020

GO:0016740

GO:0016787

GO:0021549

GO:0021987

GO:0031100

GO:0042803

GO:0044208

GO:0045296

GO:0046452

GO:0046654

GO:0048856

GO:0055086

GO:0070062

GO:0097294

GO:0098761

GO:1901135

HMNXSV003041780

ILMN_1673991

PH_hs_0005040

TC02001260.hg

TC02003807.hg

g2317691_3p_at

Participates

as a component of

ATIC(1-230)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

ATIC(1-229)-p-7Y-ALK(1058-1620) fusion [cytosol]

ATIC(1-230)-ALK(1059-1620) fusion [cytosol]

ATIC(1-229)-ALK(1058-1620) fusion [cytosol]

ATIC [cytosol]

Modified Residues

Name

Insertion of residues 1059 to 1620 at 231 from UniProt:Q9UM73 ALK

Coordinate

231

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
anaplastic large cell lymphoma	DOID:0050744

Cross References

RefSeq

NP_004035.2

ENSEMBL

ENSP00000236959, ENST00000236959, ENSG00000138363, ENST00000435675, ENSP00000415935

OpenTargets

ENSG00000138363

Mondo

0020325

ZINC - Substances

PUR9_HUMAN

ZINC - Biogenic

PUR9_HUMAN

ZINC target

P31939

PRO

P31939

GlyGen

P31939

PDB

1PL0, 5UY8, 1PKX, 1P4R, 5UZ0

ZINC - Metabolites

PUR9_HUMAN

GeneCards

ATIC

HPA

ENSG00000138363-ATIC

Pharos - Targets

P31939

Orphanet

ATIC

ZINC - Predictions - Purchasable

PUR9_HUMAN

HMDB Protein

HMDBP00882

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.553	2

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