ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol]

Stable Identifier
R-HSA-9710833
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Bifunctional purine biosynthesis protein ATIC, PUR9_HUMAN
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
10706887 Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis

Peeters, B, Morris, SW, De Wolf-Peeters, C, Siebert, R, Marynen, P, Gesk, S, Ma, Z, Schlegelberger, B, Cui, X, Cools, J, Wlodarska, I

Blood 2000
10706082 A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma

Falini, B, Lanfrancone, L, Campo, E, Trinei, M, Mason, DY, Pelicci, PG, Pulford, K

Cancer Res 2000
External Reference Information
External Reference
UniProt:P31939 ATIC
Gene Names
ATIC, PURH, OK/SW-cl.86
Chain
chain:1-592, initiator methionine:, chain:2-592
Reference Genes
BioGPS Gene:471 ATIC
COSMIC (genes):ATIC ATIC
CTD Gene:471 ATIC
dbSNP Gene:471 ATIC
ENSEMBL:ENSG00000138363 ATIC
ENSEMBL_homo_sapiens_GENE:ENSG00000138363.15 ATIC
HGNC:794 ATIC
KEGG Gene (Homo sapiens):471 ATIC
Monarch:471 ATIC
NCBI Gene:471 ATIC
OMIM:601731 ATIC
UCSC:P31939 ATIC
Reference Transcript
Other Identifiers
11715755_a_at
16890490
208758_PM_at
208758_at
2526766
2526767
2526768
2526769
2526770
2526771
2526772
2526776
2526777
2526779
2526780
2526782
2526783
2526784
2526785
2526786
2526787
2526788
2526793
2526795
2526801
2526802
2526803
2526804
38811_at
471
8048120
A_23_P68087
D82348_at
GE57324
GO:0003360
GO:0003824
GO:0003937
GO:0004643
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005886
GO:0006139
GO:0006164
GO:0006177
GO:0006189
GO:0006575
GO:0008152
GO:0010035
GO:0016020
GO:0016740
GO:0016787
GO:0021549
GO:0021987
GO:0031100
GO:0042803
GO:0043226
GO:0044208
GO:0045296
GO:0046452
GO:0046654
GO:0048856
GO:0055086
GO:0070062
GO:0097294
GO:0098761
GO:1901135
HMNXSV003041780
ILMN_1673991
PH_hs_0005040
TC02001260.hg
TC02003807.hg
g2317691_3p_at
Participates
as a component of
Other forms of this molecule
ATIC(1-229)-p-7Y-ALK(1058-1620) fusion [cytosol]
ATIC(1-230)-ALK(1059-1620) fusion [cytosol]
ATIC(1-229)-ALK(1058-1620) fusion [cytosol]
ATIC [cytosol]
Modified Residues
Name
Insertion of residues 1059 to 1620 at 231 from UniProt:Q9UM73 ALK
Coordinate
231
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1358
Coordinate
1358
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Cross References
RefSeq
OpenTargets
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Metabolites
IntEnz
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (1)
Cite Us!