TPM3(2-258)-p-7Y ALK(1059-1620) fusion [cytosol]

Stable Identifier
R-HSA-9710837
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Tropomyosin alpha-3 chain, TPM3_HUMAN
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
10934142 TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors

Pinkus, GS, Pinkus, JL, Rubin, BP, Perez-Atayde, A, Hibbard, MK, Fletcher, JA, Xiao, S, Yi, ES, Fletcher, CD, Lawrence, B, Dal Cin, P

Am J Pathol 2000
10216106 A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation

Dastugue, N, Delsol, G, Mariamé, B, Lamant, L, Pulford, K

Blood 1999
External Reference Information
External Reference
Gene Names
TPM3
Chain
initiator methionine:1, initiator methionine:, initiator methionine:, chain:2-285
Other Identifiers
0001660520
0005690047
0006590484
11715666_a_at
11715667_s_at
11721289_at
11731455_at
11746919_a_at
11749935_s_at
11750045_x_at
214365_at
222976_3p_s_at
222976_s_at
224164_at
238065_at
238079_at
2436522
2436523
2436525
2436527
2436528
2436529
2436530
2436531
2436532
2436533
2436534
2436535
2436536
2436537
2436538
2436539
2436540
2436541
2436543
2436546
2436548
2436550
2436552
2436553
2436554
2436557
2436558
2436564
2436565
2436566
2436569
2436570
2436571
2436574
2436575
3069273
32754_at
3588684
3660774
3815587
3834246
3834250
43197_at
55837_at
57840_at
7170
73377_at
75021_at
7920472
8142468
89615_at
A_23_P346086
A_24_P393880
A_32_P119197
A_33_P3223980
A_33_P3223990
A_33_P3346193
GE84825
GE85555
GO:0001725
GO:0003674
GO:0003779
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005862
GO:0005884
GO:0006936
GO:0007010
GO:0007015
GO:0008092
GO:0008150
GO:0015629
GO:0030049
GO:0032991
GO:0043226
GO:0051015
GO:0070062
HMNXSV003000428
HMNXSV003018117
HMNXSV003038944
Hs.146070.0.A1_3p_at
Hs.169514.0.A1_3p_at
Hs.85844.3.S1_3p_at
ILMN_1660775
ILMN_1686388
ILMN_1697567
ILMN_1747696
PH_hs_0029336
PH_hs_0040951
X04201_at
g12653954_3p_a_at
g12653954_3p_s_at
g12653954_3p_x_at
g9508584_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 1059 to 1620 at 259 from UniProt:Q9UM73 ALK
Coordinate
259
Name
Replacement of residues 258 to 258 by EV
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1358
Coordinate
1358
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Interactors (6)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9Y6D9 MAD1L1  1 0.849 10
 UniProt:Q8N0S2 SYCE1  1 0.735 7
 UniProt:O14879 IFIT3  1 0.696 5
 UniProt:Q14164 IKBKE  4 0.589 2
 UniProt:P21796 VDAC1  4 0.564 4
 UniProt:P13569 CFTR  17 0.527 11
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