Reactome | EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol]

EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol]

Stable Identifier

R-HSA-9710850

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Elongation factor 1-gamma, EF1G_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        EEF1G(1-343)-6Y ALK(1106-1620) fusion dimer [cytosol] (Homo sapiens)
        
        EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
28659337	Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK gene Ferreiro, JF, Tousseyn, T, Uyttebroeck, A, Michaux, L, Devos, T, Cools, J, Geerdens, E, Jacobs, K, Wlodarska, I, Doms, K, Bempt, MV, van der Krogt, JA, Pierre, P, Vandenberghe, P, Pluys, U, Mentens, N	Haematologica	2017

External Reference Information

External Reference

UniProt:P26641 EEF1G

Gene Names

EEF1G, EF1G, PRO1608

Chain

initiator methionine:, chain:2-437

Reference Genes

BioGPS Gene:1937 EEF1G

COSMIC (genes):EEF1G EEF1G

CTD Gene:1937 EEF1G

dbSNP Gene:1937 EEF1G

ENSEMBL:ENSG00000254772 EEF1G

ENSEMBL_homo_sapiens_GENE:ENSG00000254772.10 EEF1G

HGNC:3213 EEF1G

KEGG Gene (Homo sapiens):1937 EEF1G

Monarch:1937 EEF1G

NCBI Gene:1937 EEF1G

OMIM:130593 EEF1G

Reference Transcript

RefSeq:NM_001404.4 EEF1G

Other Identifiers

11726318_s_at

11753342_x_at

11753592_x_at

16739276

1676_s_at

17063066

1937

200689_3p_x_at

200689_PM_x_at

200689_x_at

211345_3p_x_at

211345_PM_x_at

211345_x_at

211927_3p_x_at

211927_PM_x_at

211927_x_at

3073748

3073750

3073751

3073752

3073753

3073755

3073756

3073757

3073758

3375806

3375807

3375809

3375811

3375815

3375816

3375817

3375820

3375822

3375824

3375825

3375826

3375829

3988067

3988082

3988084

73099_at

7948679

A_23_P13344

A_24_P287198

A_24_P467358

GE61363

GO:0003746

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005783

GO:0005829

GO:0006412

GO:0006414

GO:0009615

GO:0016020

GO:0043226

GO:0045182

GO:0045296

GO:0070062

HMNXSV003051962

HMNXSV003053972

Hs.2186.3.S1_3p_a_at

Hs.2186.3.S1_3p_x_at

ILMN_1680437

ILMN_2262288

M55409_s_at

PH_hs_0029532

TC11003185.hg

TC11003483.hg

g4503480_3p_a_at

g7770136_3p_a_at

Participates

as a component of

EEF1G(1-343)-6Y ALK(1106-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

EEF1G [cytosol]

EEF1G(1-343)-ALK(1106-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1106 to 1620 at 344 from UniProt:Q9UM73 ALK

Coordinate

344

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1358

Coordinate

1358

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
anaplastic large cell lymphoma	DOID:0050744

Cross References

RefSeq

NP_001395.1

OpenTargets

ENSG00000254772

GeneCards

P26641

HPA

ENSG00000254772-EEF1G

Ensembl

ENSP00000331901, ENSG00000254772, ENST00000329251

PRO

P26641

Pharos - Targets

P26641

PDB

5JPO, 5DQS, 1PBU

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24534 EEF1B2	1	EEF1B2 [cytosol] (R-HSA-156926)	0.885	12
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.813	8
UniProt:P29692-2 EEF1D			0.666	4
UniProt:P26640 VARS1	1	VARS [cytosol] (R-HSA-379648)	0.643	4
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.643	5
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.643	5
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.643	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:P14679-2 P146792			0.556	3
UniProt:P32497	1	NIP1 [cytosol] (R-SCE-72550)	0.556	3
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [nucleoplasm] (R-HSA-5625721) p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q8WUW1 BRK1	1	BRK1 [cytosol] (R-HSA-1671645)	0.556	3
UniProt:P32601 DSS4			0.556	3
UniProt:P40560 YIA1			0.556	3
UniProt:Q9HB07 MYG1			0.556	3
UniProt:P49090	1	ASNS [cytosol] (R-SCE-70597-2)	0.556	3
UniProt:Q13011 ECH1	3	ECH1 [mitochondrial matrix] (R-HSA-9838037) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.553	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P49589 CARS1	3	CARS [cytosol] (R-HSA-379602) CARS1(2-606)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711977) CARS1(2-606)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711974)	0.527	3
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q9NPJ1 MKKS	1	MKKS [cytosol] (R-HSA-5624086)	0.527	2
UniProt:O15357 INPPL1	1	INPPL1 [cytosol] (R-HSA-913354)	0.527	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	2
UniProt:Q969Q1 TRIM63	1	TRIM63 [cytosol] (R-HSA-976020)	0.508	2
UniProt:A0A096LP01 SIM26			0.462	2

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