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APOE-4 [extracellular region]
Stable Identifier
R-HSA-9711070
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Apolipoprotein E isoform 4, APOE_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q8IUW6 Q8IUW6
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Amyloid fibrils have additional components (Homo sapiens)
APOE-4 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02649 APOE
Gene Names
APOE
Chain
signal peptide:1-18, chain:19-317
Reference Genes
BioGPS Gene:348 APOE
COSMIC (genes):APOE APOE
CTD Gene:348 APOE
dbSNP Gene:348 APOE
ENSEMBL:ENSG00000130203 APOE
ENSEMBL_homo_sapiens_GENE:ENSG00000130203.10 APOE
HGNC:613 APOE
KEGG Gene (Homo sapiens):348 APOE
Monarch:348 APOE
NCBI Gene:348 APOE
OMIM:107741 APOE
UCSC:P02649 APOE
Reference Transcript
RefSeq:NM_001302690.1 APOE
RefSeq:NM_001302689.1 APOE
RefSeq:NM_001302691.1 APOE
RefSeq:NM_001302688.1 APOE
RefSeq:NM_000041.3 APOE
Other Identifiers
11744068_x_at
16863115
203381_PM_s_at
203381_s_at
203382_PM_s_at
203382_s_at
212884_PM_x_at
212884_x_at
348
3835880
3835883
3835884
3835886
3835887
3835888
3835889
3835890
608_at
8029530
A_14_P133396
A_23_P164650
A_33_P3223592
GE80881
GO:0000302
GO:0001540
GO:0001937
GO:0002021
GO:0002376
GO:0003013
GO:0005102
GO:0005198
GO:0005215
GO:0005319
GO:0005515
GO:0005543
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005771
GO:0005783
GO:0005788
GO:0005794
GO:0005886
GO:0006351
GO:0006355
GO:0006629
GO:0006641
GO:0006707
GO:0006869
GO:0006874
GO:0006898
GO:0006954
GO:0006979
GO:0007010
GO:0007186
GO:0007263
GO:0007271
GO:0007616
GO:0008092
GO:0008201
GO:0008202
GO:0008203
GO:0008289
GO:0010467
GO:0010468
GO:0010544
GO:0010596
GO:0010629
GO:0010875
GO:0010877
GO:0010976
GO:0010977
GO:0012501
GO:0015909
GO:0016020
GO:0016192
GO:0016209
GO:0017038
GO:0019068
GO:0019899
GO:0019934
GO:0023052
GO:0030154
GO:0030163
GO:0030195
GO:0030312
GO:0030425
GO:0030516
GO:0030669
GO:0031012
GO:0031175
GO:0031410
GO:0031982
GO:0032438
GO:0032489
GO:0032805
GO:0033344
GO:0033700
GO:0034330
GO:0034360
GO:0034361
GO:0034362
GO:0034363
GO:0034364
GO:0034365
GO:0034372
GO:0034374
GO:0034375
GO:0034380
GO:0034382
GO:0034384
GO:0034447
GO:0035641
GO:0036211
GO:0042060
GO:0042157
GO:0042158
GO:0042159
GO:0042311
GO:0042470
GO:0042627
GO:0042632
GO:0042802
GO:0042803
GO:0042981
GO:0042982
GO:0043025
GO:0043083
GO:0043226
GO:0043254
GO:0043395
GO:0043407
GO:0043524
GO:0043537
GO:0043691
GO:0044794
GO:0044877
GO:0045088
GO:0045541
GO:0045807
GO:0045893
GO:0046889
GO:0046907
GO:0046911
GO:0046983
GO:0048156
GO:0048168
GO:0048662
GO:0048844
GO:0048856
GO:0048870
GO:0050709
GO:0050728
GO:0050750
GO:0050807
GO:0050877
GO:0051000
GO:0051044
GO:0051246
GO:0051248
GO:0051651
GO:0055065
GO:0055088
GO:0055089
GO:0060228
GO:0060999
GO:0061024
GO:0061136
GO:0061771
GO:0062023
GO:0065003
GO:0070062
GO:0070326
GO:0070328
GO:0070374
GO:0071682
GO:0071813
GO:0071830
GO:0071831
GO:0072359
GO:0072562
GO:0090090
GO:0090181
GO:0090205
GO:0090209
GO:0097006
GO:0097113
GO:0097114
GO:0097487
GO:0098542
GO:0098754
GO:0098772
GO:0098869
GO:0098978
GO:0120009
GO:0120020
GO:1900221
GO:1900223
GO:1900272
GO:1902430
GO:1902952
GO:1902991
GO:1902995
GO:1903002
GO:1903561
GO:1905860
GO:1905890
GO:1905906
GO:1905907
GO:1905908
GO:1905920
GO:1990777
GO:2000822
HMNXSV003039072
Hs.169401.0.S1_3p_a_at
ILMN_1740938
M12529_at
PH_hs_0022287
TC19000633.hg
g4557324_3p_a_at
Participates
as a component of
Amyloid fibrils [plasma membrane] (Homo sapiens)
as an input of
Amyloid fibrils have additional components (Homo sapiens)
Other forms of this molecule
APOE [early endosome]
APOE [endosome lumen]
APOE [endosome membrane]
APOE [clathrin-coated endocytic vesicle membrane]
APOE [plasma membrane]
APOE [endocytic vesicle lumen]
APOE [extracellular region]
p-APOE [endoplasmic reticulum lumen]
APOE [endoplasmic reticulum lumen]
Modified Residues
Name
L-cysteine 112 replaced with L-arginine
Coordinate
112
PsiMod
L-cysteine removal [MOD:01635]
A protein modification that effectively removes or replaces an L-cysteine.
L-arginine residue [MOD:00011]
A protein modification that effectively converts a source amino acid residue to an L-arginine.
Cross References
RefSeq
NP_001289617.1
,
NP_001289618.1
,
NP_001289620.1
,
NP_000032.1
,
NP_001289619.1
OpenTargets
ENSG00000130203
HPA
ENSG00000130203-APOE
GeneCards
P02649
Ensembl
ENST00000252486
,
ENSG00000130203
,
ENSP00000252486
PRO
P02649
Pharos - Targets
P02649
Orphanet
15940
HMDB Protein
HMDBP01986
PDB
1LPE
,
7FCR
,
1EA8
,
7FCS
,
1BZ4
,
1GS9
,
2KNY
,
2L7B
,
2KC3
,
1H7I
,
1NFO
,
1NFN
,
6NCN
,
8AX8
,
1OR3
,
8CE0
,
7UVJ
,
6NCO
,
1LE4
,
1B68
,
1OR2
,
8CDY
,
8GRX
,
8AX9
,
1OEG
,
6IWB
,
1LE2
,
1OEF
Interactors (58)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.809
11
UniProt:Q07954 LRP1
2
LRP1 [plasma membrane]
(R-HSA-1454844)
LRP1 [endocytic vesicle membrane]
(R-HSA-2230981)
0.784
23
UniProt:P05067-PRO_0000000093 APP
0.75
4
ChEBI:28304 HEPARIN
0.733
8
UniProt:P01130 LDLR
4
LDLR [endolysosome membrane]
(R-HSA-6784818)
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [plasma membrane]
(R-HSA-171053)
0.71
4
UniProt:P00738 HP
7
HP [specific granule lumen]
(R-HSA-6799622)
HP [extracellular region]
(R-HSA-6799677)
HP [tertiary granule lumen]
(R-HSA-6800879)
5xHC-HP(162-406) [endocytic vesicle lumen]
(R-HSA-2230973)
7xHC-HP(19-160) [endocytic vesicle lumen]
(R-HSA-2230994)
5xHC-HP(162-406) [extracellular region]
(R-HSA-2168875)
7xHC-HP(19-160) [extracellular region]
(R-HSA-2168848)
0.675
7
UniProt:P08603 CFH
1
CFH [extracellular region]
(R-HSA-976788)
0.672
8
UniProt:P02649 APOE
10
APOE [early endosome]
(R-HSA-2429687)
APOE [endosome lumen]
(R-HSA-174804)
APOE [endosome membrane]
(R-HSA-174766)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [plasma membrane]
(R-HSA-174615)
APOE-4 [extracellular region]
(R-HSA-9711070)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
APOE [extracellular region]
(R-HSA-174646)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
0.641
9
UniProt:Q9NZC2 TREM2
1
TREM2 [plasma membrane]
(R-HSA-197664)
0.602
4
UniProt:O75069 TMCC2
0.593
5
ChEBI:241349 DIMYRISTOYLPHOSPHATIDYL CHOLINE
0.59
3
UniProt:P21796 VDAC1
7
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
Ub-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834989)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
K63polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834037)
p-S65-Ub:VDAC1 [mitochondrial outer membrane]
(R-HSA-9834991)
0.589
2
UniProt:P02748 C9
1
C9(22-559) [extracellular region]
(R-HSA-173717)
0.564
2
UniProt:Q8TBC4 UBA3
2
UBA3 [cytosol]
(R-HSA-947632)
G76-NEDD8-C237-UBA3 [cytosol]
(R-HSA-8951640)
0.556
3
UniProt:Q9HBG4 ATP6V0A4
2
ATP6V0A4 [phagocytic vesicle membrane]
(R-HSA-1222302)
ATP6V0A4 [endosome membrane]
(R-HSA-912605)
0.556
3
UniProt:P11137-4 MAP2
0.556
3
UniProt:P02795 MT2A
1
MT2A [cytosol]
(R-HSA-1031707)
0.556
3
UniProt:Q06481-5 APLP2
0.556
3
UniProt:P26441 CNTF
1
CNTF [extracellular region]
(R-HSA-5696441)
0.556
3
UniProt:Q3SYB3 FX4L6
0.556
3
UniProt:Q9NUB4 CT141
0.556
3
UniProt:Q6PID6 TTC33
0.556
3
UniProt:P10636-6 MAPT
0.556
3
UniProt:Q9Y3D2 MSRB2
1
MSRB2 [cytosol]
(R-HSA-5676906)
0.556
3
UniProt:Q8IUW6 Q8IUW6
0.556
3
IntAct:EBI-25832170 ORF
0.556
3
UniProt:Q13829 TNFAIP1
1
TNFAIP1 [cytosol]
(R-HSA-9696531)
0.556
3
UniProt:Q8IUW3 SPA2L
0.556
3
UniProt:Q14114-3 Q141143
0.556
3
UniProt:Q9NS23-4 RASSF1
0.556
3
UniProt:Q6ZNA4-2 Q6ZNA42
0.556
3
UniProt:P52756 RBM5
1
RBM5 [nucleoplasm]
(R-HSA-72049)
0.556
3
IntAct:EBI-25831191 CCSB
0.556
3
UniProt:Q9Y6C2-2 EMILIN1
0.556
3
UniProt:Q9NYH9 UTP6
1
UTP6 [nucleoplasm]
(R-HSA-6790674)
0.556
3
UniProt:Q9H6J7-2 CSTPP1
0.556
3
UniProt:P17028 ZNF24
0.556
3
UniProt:P09382 LGALS1
2
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
0.556
3
IntAct:EBI-25832355 CCSB
0.556
3
UniProt:Q8IY40 Q8IY40
0.556
3
UniProt:O75409 HYPM
0.556
3
UniProt:Q9H816 DCLRE1B
1
DCLRE1B [nucleoplasm]
(R-HSA-6785735)
0.556
3
UniProt:Q8WTV0-2 SCARB1
2
SCARB1-2 [endocytic vesicle membrane]
(R-HSA-2512788)
SCARB1-2 [plasma membrane]
(R-HSA-349415)
0.556
3
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.556
3
UniProt:Q9UIJ7 AK3
1
AK3 [mitochondrial matrix]
(R-HSA-1008241)
0.556
3
UniProt:P27958-PRO_0000037570
0.537
4
UniProt:P60033 CD81
1
CD81 [plasma membrane]
(R-HSA-197933)
0.527
7
UniProt:P02655 APOC2
3
APOC2 [early endosome]
(R-HSA-2429686)
APOC2 [cytosol]
(R-HSA-2404145)
APOC2 [extracellular region]
(R-HSA-174699)
0.527
2
UniProt:P08254 MMP3
6
MMP3(55-99) [extracellular region]
(R-HSA-1604687)
MMP3(18-54) [extracellular region]
(R-HSA-1604705)
MMP3(55-477) [extracellular region]
(R-HSA-1604735)
MMP3(18-477) [extracellular region]
(R-HSA-1604707)
MMP3 [extracellular region]
(R-HSA-8943665)
MMP3(100-477) [extracellular region]
(R-HSA-1430778)
0.527
2
UniProt:Q9H8J5 MANS1
0.527
2
UniProt:Q13201 MMRN1
2
MMRN1(20-1228) [extracellular region]
(R-HSA-114635)
MMRN1(20-1228) [platelet alpha granule lumen]
(R-HSA-114634)
0.527
2
UniProt:P20036 HLA-DPA1
9
HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130667)
HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130739)
HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane]
(R-HSA-2214387)
HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane]
(R-HSA-2130337)
HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane]
(R-HSA-2130648)
HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130485)
HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane]
(R-HSA-2130435)
HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane]
(R-HSA-2130639)
HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane]
(R-HSA-197586)
0.527
2
UniProt:P09238 MMP10
2
MMP10 [extracellular region]
(R-HSA-1442488)
MMP10(18-476) [extracellular region]
(R-HSA-1604748)
0.527
2
UniProt:Q9UBD9 CLCF1
1
CLCF1 [extracellular region]
(R-HSA-5693175)
0.524
3
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.524
4
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.482
3
UniProt:Q53EL6 PDCD4
1
PDCD4 [cytosol]
(R-HSA-5432887)
0.482
3
UniProt:P50502 ST13
1
ST13 [cytosol]
(R-HSA-5255410)
0.482
3
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