Cellular response to chemical stress

Stable Identifier
R-HSA-9711123
Type
Pathway
Species
Homo sapiens
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Cells are equipped with versatile physiological stress responses to prevent hazardous consequences resulting from exposure to chemical insults of endogenous and exogenous origin. Even at equitoxic doses, different stressors induce distinctive and complex signaling cascades. The responses typically follow cell perturbations at the subcellular organelle level.

Expression of heme oxygenase 1 (HMOX1) is regulated by various indicators of cell stress. Cytoprotection by HMOX1 is exerted directly by HMOX1 and by the antioxidant metabolites it produces through the degradation of heme (Origassa et al, 2013; Ryter et al, 2006).

Reactive oxygen and nitrogen species (RONS) are important mediators of chemical stress, as they are produced endogenously in mitochondria, and also result from redox activities of many toxins and heavy metal cations. The points of RONS action in the cell are plasma and ER membrane lipids, as well as DNA, both acting as sensors for the cellular response. On the other hand, chemotherapeutic agents exert their action via generation of RONS and induction of cancer cell apoptosis, while drug resistance associates with RONS-induced cancer cell survival (Sampadi et al, 2020; Moldogazieva et al, 2018).

Literature References
PubMed ID Title Journal Year
16601269 Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

Alam, J, Choi, AM, Ryter, SW

Physiol Rev 2006
30327380 Reactive Oxygen and Nitrogen Species-Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy

Terentiev, AA, Lutsenko, SV, Moldogazieva, NT

Cancer Res 2018
20840865 Oxidative stress, inflammation, and cancer: how are they linked?

Gupta, SC, Chaturvedi, MM, Aggarwal, BB, Reuter, S

Free Radic Biol Med 2010
32189037 Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action

Olsen, JV, Sampadi, B, Munk, S, Mullenders, LHF, van de Water, B, de Groot, AJ, Pines, A, Vrieling, H, Mišovic, B

Arch Toxicol 2020
30644759 Chemical activation of estrogen and aryl hydrocarbon receptor signaling pathways and their interaction in toxicology and metabolism

Luch, A, Tarnow, P, Tralau, T

Expert Opin Drug Metab Toxicol 2019
28230817 Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies

Vesela, E, Chroma, K, Mistrik, M, Turi, Z

Biomolecules 2017
24179613 Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury

Câmara, N, Origassa, C

World journal of hepatology 2013
22515967 Comparative analysis of perturbed molecular pathways identified in in vitro and in vivo toxicology studies

Jennings, P, Wiesinger, M, Lukas, A, Mayer, B

Toxicol In Vitro 2012
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