SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9711954
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Sequestosome-1, SQSTM_HUMAN
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
25813404 Novel ALK fusion partners in lung cancer

Iyevleva, AG, Raskin, GA, Tiurin, VI, Sokolenko, AP, Mitiushkina, NV, Aleksakhina, SN, Garifullina, AR, Strelkova, TN, Merkulov, VO, Ivantsov, AO, Kuligina, ESh, Pozharisski, KM, Togo, AV, Imyanitov, EN

Cancer Lett 2015
21134980 Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma

Takeuchi, K, Soda, M, Togashi, Y, Ota, Y, Sekiguchi, Y, Hatano, S, Asaka, R, Noguchi, M, Mano, H

Haematologica 2011
External Reference Information
External Reference
Gene Names
SQSTM1, ORCA, OSIL
Chain
initiator methionine:1, initiator methionine:, chain:2-440
Other Identifiers
0000730647
11717290_s_at
11727031_a_at
11745754_x_at
11752843_x_at
11756761_x_at
16993458
201471_s_at
213112_s_at
2844499
2844500
2844505
2844506
2844507
2844508
2844509
2844512
2844513
2844514
2844515
2844516
2844518
2844523
2844524
2844528
2844529
2844535
2844536
2844537
2844538
2844539
2844540
2844541
2844542
40898_at
8110569
8878
A_14_P109999
A_23_P81399
GE79794
GO:0000122
GO:0000407
GO:0000422
GO:0000423
GO:0000425
GO:0000932
GO:0001934
GO:0002376
GO:0002931
GO:0003674
GO:0004674
GO:0005080
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005783
GO:0005829
GO:0005929
GO:0006464
GO:0006468
GO:0006511
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0007005
GO:0007032
GO:0007165
GO:0007267
GO:0008104
GO:0008150
GO:0008219
GO:0008270
GO:0009056
GO:0009058
GO:0010821
GO:0016192
GO:0016197
GO:0016234
GO:0016235
GO:0016236
GO:0016301
GO:0016605
GO:0019899
GO:0019901
GO:0030017
GO:0030154
GO:0030971
GO:0031397
GO:0031410
GO:0031625
GO:0032182
GO:0034641
GO:0035255
GO:0035556
GO:0035973
GO:0042169
GO:0042802
GO:0043065
GO:0043066
GO:0043122
GO:0043130
GO:0043167
GO:0043226
GO:0043231
GO:0044753
GO:0044754
GO:0044877
GO:0045944
GO:0046578
GO:0046872
GO:0061635
GO:0061912
GO:0070062
GO:0070498
GO:0070530
GO:0097225
GO:0097413
GO:0098780
GO:1900273
GO:1903078
GO:1905719
HMNXSV003033729
Hs.279891.1.A1_3p_at
ILMN_1662618
ILMN_1703856
PH_hs_0010763
U46751_at
g4505570_3p_s_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 1058 to 1620 at 252 from UniProt:Q9UM73 ALK
Coordinate
252
Disease
Name Identifier Synonyms
lung adenocarcinoma DOID:3910 nonsmall cell adenocarcinoma
diffuse large B-cell lymphoma DOID:0050745
Interactors (51)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9GZQ8 MAP1LC3B  3 0.968 24
 UniProt:Q14145 KEAP1  2 0.959 18
 UniProt:P60520 GABARAPL2  3 0.957 20
 UniProt:Q13501 SQSTM1  4 0.888 10
 UniProt:O95166 GABARAP  3 0.886 14
 UniProt:Q9H0R8 GABARAPL1  3 0.885 15
 UniProt:P41743 PRKCI  3 0.862 10
 UniProt:Q9H492 MAP1LC3A  3 0.852 10
 IntAct:EBI-4399559 UBIQ      0.829 6
 UniProt:P0CG48 UBC  325 0.806 5
 UniProt:Q16543 CDC37  1 0.801 8
 UniProt:Q14596 NBR1  2 0.775 7
 UniProt:P58004 SESN2  1 0.728 9
 UniProt:Q9BXW4 MAP1LC3C  3 0.702 3
 UniProt:Q9Y4K3 TRAF6  8 0.688 4
 UniProt:Q5S007 LRRK2  1 0.67 18
 UniProt:Q15038 DAZP2      0.666 4
 UniProt:Q13163 MAP2K5  1 0.666 5
 UniProt:P54253 ATX1      0.666 4
 UniProt:P42858 HTT  1 0.649 8
 UniProt:P54725 RAD23A  1 0.635 3
 UniProt:P11473 VDR  2 0.591 4
 UniProt:Q6IRU7  1 0.564 2
 UniProt:Q96CV9 OPTN  4 0.558 7
 UniProt:Q9UGJ0 PRKAG2  3 0.556 3
 UniProt:O14576-2 O145762      0.556 3
 UniProt:Q9UBQ0-2 VPS29      0.556 3
 UniProt:P34972 CNR2  1 0.556 5
 UniProt:A0A024RC47 A0A024RC47      0.556 3
 UniProt:P19544-6 WT1      0.556 3
 UniProt:P0DMV8 HSPA1A  4 0.556 3
 UniProt:P12709  4 0.556 3
 UniProt:A8K2U6 A8K2U6      0.556 3
 IntAct:EBI-25830852 RZPDO839G03145      0.556 3
 UniProt:P05067 APP  20 0.556 6
 UniProt:P07437 TUBB  3 0.556 3
 UniProt:Q9UNE7 STUB1  1 0.556 3
 UniProt:P37840 SNCA  4 0.556 3
 UniProt:P84022 SMAD3  21 0.543 3
 UniProt:Q2V2M9 FHOD3      0.543 6
 UniProt:Q2V2M9-4 FHOD3      0.543 4
 UniProt:O95817 BAG3  1 0.537 3
 UniProt:Q05513 PRKCZ  5 0.527 4
 UniProt:Q15334 L2GL1      0.527 2
 UniProt:Q96B97 SH3KBP1  3 0.524 4
 UniProt:Q9Y6K9 IKBKG  12 0.524 2
 UniProt:Q9UDY8 MALT1  1 0.524 2
 UniProt:P38182  12 0.508 3
 UniProt:O70405  7 0.499 2
 UniProt:P04629 NTRK1  4 0.499 2
 UniProt:P12504 VIF      0.499 2
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