Reactome | MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]

MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]

Stable Identifier

R-HSA-9711971

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fullName evidence="28"Moesin, MOES_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        MSN(2-448)-p-7Y ALK(1064-1620) fusion dimer [cytosol] (Homo sapiens)
        
        MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
11310834	Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma Tort, F, Pinyol, M, Pulford, K, Roncador, G, Hernández, L, Nayach, I, Kluin-Nelemans, HC, Kluin, P, Touriol, C, Delsol, G, Mason, D, Campo, E	Lab Invest	2001

External Reference Information

External Reference

UniProt:P26038 MSN

Gene Names

MSN

Chain

initiator methionine:1, chain:2-577

Reference Genes

BioGPS Gene:4478 MSN

COSMIC (genes):MSN MSN

CTD Gene:4478 MSN

dbSNP Gene:4478 MSN

ENSEMBL:ENSG00000147065 MSN

HGNC:7373 MSN

KEGG:hsa:4478 MSN

Monarch:4478 MSN

NCBI Gene:4478 MSN

OMIM:309845 MSN

UCSC:P26038 MSN

Reference Transcript

RefSeq:NM_002444.3 MSN

Other Identifiers

11715716_at

11715717_s_at

11749374_a_at

17104253

17104259

200600_PM_at

200600_at

233749_PM_at

233749_at

2804475

2804476

2804477

2804484

2804487

2804488

2804490

3979628

3979629

3979630

3979631

3979632

3979633

3979634

3979635

3979639

3979641

3979643

3979645

3979646

3979660

3979671

3979680

3979681

3979685

3979686

3979687

3979688

3979689

3979690

3979691

3979693

3979694

3979695

3979697

3979698

3979699

3979700

40771_at

4478

8167965

A_14_P115949

A_19_P00801279

A_23_P73589

A_23_P73593

A_24_P186370

A_24_P453819

A_33_P3407606

GE79525

GO:0001771

GO:0001931

GO:0002376

GO:0003723

GO:0003725

GO:0003779

GO:0005102

GO:0005198

GO:0005200

GO:0005515

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005902

GO:0005912

GO:0005925

GO:0007010

GO:0007159

GO:0007163

GO:0008092

GO:0008360

GO:0008361

GO:0009986

GO:0010628

GO:0016020

GO:0016323

GO:0016324

GO:0019899

GO:0019901

GO:0022612

GO:0022614

GO:0030154

GO:0030175

GO:0031143

GO:0031528

GO:0031982

GO:0042098

GO:0042995

GO:0043226

GO:0045177

GO:0045198

GO:0045732

GO:0048471

GO:0048856

GO:0048870

GO:0050839

GO:0050900

GO:0061028

GO:0070062

GO:0070489

GO:0071803

GO:0071944

GO:0072562

GO:0072678

GO:1902115

GO:1902966

GO:2000401

GO:2000643

HMNXSV003005143

HMNXSV003010817

HMNXSV003023954

HMNXSV003026308

HMNXSV003026763

Hs.302098.0.S1_3p_at

ILMN_1659895

M69066_at

PH_hs_0020689

PH_hs_0029317

PH_hs_0035636

TC0X000352.hg

TC0X000353.hg

TC0X001741.hg

g4505256_3p_at

p17197

p17198

p17199

Participates

as a component of

MSN(2-448)-p-7Y ALK(1064-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

MSN [cytosol]

MSN(2-448)-ALK(1064-1620) fusion [cytosol]

p-T558-MSN [cytosol]

Modified Residues

Name

Insertion of residues 1064 to 1620 at 449 from UniProt:Q9UM73 ALK

Coordinate

449

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
anaplastic large cell lymphoma	DOID:0050744

Cross References

RefSeq

NP_002435.1

COSMIC

COSF421

OpenTargets

ENSG00000147065

ENSEMBL

ENST00000360270, ENSG00000147065, ENSP00000353408

Mondo

0020325

HPA

ENSG00000147065-MSN

GeneCards

MSN

PRO

P26038

Pharos - Targets

P26038

Orphanet

MSN

GlyGen

P26038

PDB

1EF1, 1SGH, 1E5W, 8CIU, 8CIS, 6TXS, 6TXQ, 8CIT, 8CIR

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.956	19
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.745	10
UniProt:O14745 NHRF1			0.684	4
UniProt:P35241 RDX	2	RDX [cytosol] (R-HSA-437348) p-T564-RDX [cytosol] (R-HSA-9662922)	0.643	3
UniProt:P97820	1	Map4k4 [cytosol] (R-MMU-3214893)	0.558	2
UniProt:P25791-3 LMO2			0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P53779 MAPK10	3	p-T221,Y223-MAPK10 [nucleoplasm] (R-HSA-450311) p-T221,Y223-MAPK10 [cytosol] (R-HSA-450214) MAPK10 [cytosol] (R-HSA-450352)	0.527	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.499	20
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	8
UniProt:P16070 CD44	2	CD44 [plasma membrane] (R-HSA-1031688) CD44 [secretory granule membrane] (R-HSA-6804776)	0.463	6
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2
UniProt:P08567 PLEK	2	PLEK [extracellular region] (R-HSA-350741) PLEK [cytosol] (R-HSA-350715)	0.462	3
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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