ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region

Stable Identifier
R-HSA-9712204
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region
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Each monomer of the ANO2 dimer contains a pore that translocates chloride ions according to the concentration gradient from the cytosol to the extracellular region (Stöhr et al. 2009, and inferred from mouse homologs). Binding of calcium ions to sites in a transmembrane helix of each monomer increases the permeability of the pore to chloride ions.
Literature References
PubMed ID Title Journal Year
19474308 TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals

Heisig, JB, Weber, BH, Wijnholds, J, Schöberl, S, Aartsen, WM, Strauss, O, Milenkovic, VM, Benz, PM, Stöhr, H, Schulz, HL

J Neurosci 2009
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Catalyst Activity

chloride channel activity of ANO2:Ca2+ [plasma membrane]

Physical Entity
ANO2:Ca2+ [plasma membrane] (Homo sapiens)
Activity
chloride channel activity (GO:0005254)
Inferred From
Ano2 dimer:Ca2+ translocates Cl- from the cytosol to the extracellular region (Mus musculus)
Cross References
Rhea
Authored
May, B  (2021-01-16)
Reviewed
Raimondi, F  (2021-08-02)
Created
May, B  (2021-01-16)
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