Reactome | SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol]

SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9713475

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein transport protein Sec31A, SC31A_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        SEC31A(1-989)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
        
        SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
16161041	Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor Mandahl, N, Panagopoulos, I, Isaksson, M, Domanski, HA, Lindblom, P, Mertens, F, Nilsson, T	Int J Cancer	2006

External Reference Information

External Reference

UniProt:O94979 SEC31A

Gene Names

SEC31A, KIAA0905, SEC31L1, HSPC275, HSPC334

Chain

chain:1-1220

Reference Genes

BioGPS Gene:22872 SEC31A

COSMIC (genes):SEC31A SEC31A

CTD Gene:22872 SEC31A

dbSNP Gene:22872 SEC31A

ENSEMBL:ENSG00000138674 SEC31A

HGNC:17052 SEC31A

KEGG:hsa:22872 SEC31A

Monarch:22872 SEC31A

NCBI Gene:22872 SEC31A

OMIM:610257 SEC31A

UCSC:O94979 SEC31A

Reference Transcript

Other Identifiers

11732334_s_at

11745764_a_at

16977411

16977474

200945_PM_s_at

200945_s_at

210616_PM_s_at

210616_s_at

22872

2775755

2775757

2775758

2775759

2775760

2775761

2775764

2775765

2775766

2775767

2775769

2775770

2775771

2775773

2775774

2775775

2775776

2775779

2775780

2775785

2775786

2775787

2775788

2775789

2775791

2775793

2775794

2775795

2775796

2775797

2775798

2775801

2775802

2775803

2775805

2775806

2775807

2775808

2775809

2775811

2775812

2775813

2775814

2775815

2775816

2775817

2775818

2775819

2775820

2775821

2775822

2775823

2775824

2775825

2775826

2775827

2775828

2775829

2775830

2775831

2775832

2775833

2775841

2775844

2775845

2775848

2775849

35827_at

3956727

45494_at

47659_at

70545_at

76169_at

8101376

A_23_P170273

A_24_P277349

GE53506

GO:0005198

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006888

GO:0007029

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030120

GO:0030127

GO:0030134

GO:0031410

GO:0043226

GO:0043231

GO:0048306

GO:0048471

GO:0051592

GO:0070971

GO:0090110

HMNXSV003012075

HMNXSV003048330

ILMN_1691409

ILMN_1724959

ILMN_2399896

PH_hs_0025516

TC04002614.hg

TC04002942.hg

g4240298_3p_a_at

p12351

Participates

as a component of

SEC31A(1-989)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

SEC31A [ER to Golgi transport vesicle membrane]

SEC31A [cytosol]

SEC31A [endoplasmic reticulum membrane]

SEC31A(1-989)-ALK(1058-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 990 from UniProt:Q9UM73 ALK

Coordinate

990

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1358

Coordinate

1358

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
inflammatory myofibroblastic tumor	DOID:0050905

Cross References

COSMIC

COSF460, COSF459

OpenTargets

ENSG00000138674

ENSEMBL

ENST00000509142, ENST00000348405, ENSP00000424635, ENSP00000309070, ENST00000395310, ENSP00000337602, ENST00000500777, ENSP00000408027, ENSP00000421464, ENSP00000426569, ENSP00000424451, ENSP00000426886, ENST00000311785, ENST00000443462, ENST00000355196, ENST00000448323, ENST00000513858, ENSP00000378721, ENSP00000347329, ENSP00000400926, ENST00000505984, ENST00000508502

HPA

ENSG00000138674-SEC31A

PRO

O94979

Pharos - Targets

O94979

GlyGen

O94979

HMDB Protein

HMDBP07990

PDB

3WXA, 7SUL

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75340 PDCD6			0.739	7
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [cytosol] (R-HSA-203981)	0.734	7
UniProt:Q96KG9 SCYL1			0.708	5
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q92734 TFG	7	TFG [cytosol] (R-HSA-5688159) TFG(1-240)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699806) TFG(1-138)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699874) TFG(1-193)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699887) TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9702029) TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702038) TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702019)	0.527	2
UniProt:P78316 NOP14	1	NOP14 [nucleoplasm] (R-HSA-6790710)	0.527	3
UniProt:Q15436 SEC23A	4	SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) p-S738,T744 SEC23A [cytosol] (R-HSA-5685740)	0.508	2