PPM1B(2-282)-p-7Y ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9713479
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Protein phosphatase 1B ecNumber3.1.3.16/ecNumber, PPM1B_HUMAN
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
27245569 Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization

Ali, SM, Hensing, T, Schrock, AB, Allen, J, Sanford, E, Gowen, K, Kulkarni, A, He, J, Suh, JH, Lipson, D, Elvin, JA, Yelensky, R, Chalmers, Z, Chmielecki, J, Peled, N, Klempner, SJ, Firozvi, K, Frampton, GM, Molina, JR, Menon, S, Brahmer, JR, MacMahon, H, Nowak, J, Ou, SH, Zauderer, M, Ladanyi, M, Zakowski, M, Fischbach, N, Ross, JS, Stephens, PJ, Miller, VA, Wakelee, H, Ganesan, S, Salgia, R

Oncologist 2016
External Reference Information
External Reference
Gene Names
PPM1B, PP2CB
Chain
initiator methionine:1, chain:2-479
Other Identifiers
0000070504
0006590348
11719712_at
11719713_a_at
11719714_at
11725259_s_at
11735019_a_at
16879581
209296_at
213225_at
2479644
2479645
2479646
2479648
2479652
2479660
2479661
2479665
2479666
2479667
2479668
2479669
2479670
2479671
32665_at
53139_at
5495
8041713
A_14_P115943
A_14_P135663
A_23_P209269
A_23_P398073
A_33_P3296352
A_33_P3407742
A_33_P3407746
GE55164
GO:0000287
GO:0002376
GO:0003674
GO:0004721
GO:0004722
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0006464
GO:0006470
GO:0006499
GO:0006950
GO:0007165
GO:0007267
GO:0008150
GO:0009058
GO:0016020
GO:0016787
GO:0016791
GO:0030145
GO:0032688
GO:0035970
GO:0043124
GO:0043167
GO:0043169
GO:0043226
GO:0046872
GO:0050687
GO:0090263
GO:0106306
GO:0106307
GO:1901223
HMNXSV003008526
Hs.5687.1.S2_3p_at
ILMN_1716862
ILMN_1727138
ILMN_1727915
ILMN_1796085
ILMN_2377210
PH_hs_0025060
g12239323_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 1058 to 1620 at 283 from UniProt:Q9UM73 ALK
Coordinate
283
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1358
Coordinate
1358
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
Cross References
ZINC - World Drugs
OpenTargets
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Metabolites
IntEnz
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
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