Reactome | VRK2 [endoplasmic reticulum membrane]

VRK2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9714457

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q86Y07 VRK2

Gene Names

VRK2

Chain

chain:1-508

Reference Genes

BioGPS Gene:7444 VRK2

COSMIC (genes):VRK2 VRK2

CTD Gene:7444 VRK2

dbSNP Gene:7444 VRK2

ENSEMBL:ENSG00000028116 VRK2

HGNC:12719 VRK2

KEGG:hsa:7444 VRK2

Monarch:7444 VRK2

NCBI Gene:7444 VRK2

OMIM:602169 VRK2

UCSC:Q86Y07 VRK2

Reference Transcript

Participates

as a candidate of

Other forms of this molecule

VRK2 [mitochondrial outer membrane]

Inferred To

VRK2 [endoplasmic reticulum membrane] (Bos taurus)

VRK2 [endoplasmic reticulum membrane] (Canis familiaris)

VRK2 [endoplasmic reticulum membrane] (Gallus gallus)

VRK2 [endoplasmic reticulum membrane] (Sus scrofa)

Vrk2 [endoplasmic reticulum membrane] (Mus musculus)

Vrk2 [endoplasmic reticulum membrane] (Rattus norvegicus)

vrk2 [endoplasmic reticulum membrane] (Danio rerio)

Cross References

RefSeq

NP_006287.2, XP_006712156.1, XP_016860347.1, XP_016860350.1, XP_006712155.1, XP_011531394.1, XP_006712154.1, NP_001123954.1, XP_016860349.1, NP_001275767.1, XP_047301704.1, NP_001123952.1, NP_001275765.1, NP_001123955.1, NP_001123953.1, NP_001275766.1, XP_006712153.1, XP_005264597.1, XP_016860348.1, XP_047301701.1, XP_016860352.1, XP_047301703.1, XP_016860351.1, NP_001275768.1

ZINC - World Drugs

VRK2_HUMAN

Guide to Pharmacology - Targets

2276

OpenTargets

ENSG00000028116

ENSEMBL

ENST00000340157, ENST00000435505, ENST00000417641, ENST00000412104, ENSP00000402375, ENST00000440705, ENSP00000497378, ENST00000648897, ENSP00000342381, ENSP00000408002, ENSP00000404156, ENSP00000398323, ENSG00000028116

ZINC - FDA approved

VRK2_HUMAN

ZINC - Substances

VRK2_HUMAN

ZINC target

Q86Y07

PRO

Q86Y07

PDB

8Q1Z, 5UU1, 6NCG, 2V62, 9FET

ZINC - Investigational

VRK2_HUMAN

HPA

ENSG00000028116-VRK2

GeneCards

VRK2

Pharos - Targets

Q86Y07

ZINC - Predictions - Purchasable

VRK2_HUMAN

HMDB Protein

HMDBP01323

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.524	2
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.483	3

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