Reactome | PGRMC2 [endosome membrane]

PGRMC2 [endosome membrane]

Stable Identifier

R-HSA-9715090

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Membrane-associated progesterone receptor component 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O15173 PGRMC2

Gene Names

PGRMC2, DG6, PMBP

Chain

chain:1-223

Reference Genes

BioGPS Gene:10424 PGRMC2

COSMIC (genes):PGRMC2 PGRMC2

CTD Gene:10424 PGRMC2

dbSNP Gene:10424 PGRMC2

ENSEMBL:ENSG00000164040.18 PGRMC2

HGNC:16089 PGRMC2

KEGG Gene (Homo sapiens):10424 PGRMC2

Monarch:10424 PGRMC2

NCBI Gene:10424 PGRMC2

OMIM:607735 PGRMC2

UCSC:O15173 PGRMC2

Reference Transcript

RefSeq:NM_006320.4 PGRMC2

Other Identifiers

0006400333

0107040044

10424

11715920_a_at

11758737_s_at

16979698

201701_PM_s_at

201701_s_at

213227_PM_at

213227_at

2785113

2785115

2785116

2785117

2785118

2785119

2785120

2785121

2785122

2785123

2785124

2785135

2785136

2785137

2785138

2785139

2785140

2785141

2785142

2785143

2785144

2785145

38821_at

8102745

A_23_P155868

A_24_P405850

GE522759

GE55150

GO:0003707

GO:0005215

GO:0005496

GO:0005515

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005783

GO:0008289

GO:0012505

GO:0015232

GO:0015886

GO:0016020

GO:0016021

GO:0020037

GO:0023052

GO:0043226

GO:0043401

GO:0048856

GO:0060089

GO:0060612

HMNXSV003028066

Hs.9071.1.A1_3p_at

ILMN_1711682

ILMN_2195236

PH_hs_0000958

TC04001537.hg

g5453915_3p_a_at

Participates

as a candidate of

RHOD endosome effectors [cytosol] (Homo sapiens)

Other forms of this molecule

PGRMC2 [endoplasmic reticulum membrane]

Inferred To

PGRMC2 [endosome membrane] (Bos taurus)

PGRMC2 [endosome membrane] (Canis familiaris)

PGRMC2 [endosome membrane] (Danio rerio)

PGRMC2 [endosome membrane] (Gallus gallus)

PGRMC2 [endosome membrane] (Schizosaccharomyces pombe)

pgrmc2 [endosome membrane] (Xenopus tropicalis)

vem-1 [endosome membrane] (Caenorhabditis elegans)

MSBP [endosome membrane] (Drosophila melanogaster)

Pgrmc2 [endosome membrane] (Mus musculus)

Pgrmc2 [endosome membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_006311.2

OpenTargets

ENSG00000164040

HPA

ENSG00000164040-PGRMC2

GeneCards

O15173

Ensembl

ENST00000296425, ENSP00000429301, ENST00000613358, ENSP00000296425, ENSG00000164040, ENST00000520121, ENSP00000481886

PRO

O15173

Pharos - Targets

O15173

HMDB Protein

HMDBP08665

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:O60906 SMPD2	1	SMPD2 [plasma membrane] (R-HSA-194337)	0.556	3
UniProt:P02787 TF	6	apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140) TF [secretory granule lumen] (R-HSA-350704) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) TF [endoplasmic reticulum lumen] (R-HSA-8956763) apoTF [endosome membrane] (R-HSA-917974) apoTF [extracellular region] (R-HSA-350754)	0.556	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.556	3
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:P01031 C5	7	C5(965-1676) [extracellular region] (R-HSA-8852713) C5aT [extracellular region] (R-HSA-8852711) C5a-desArg [extracellular region] (R-HSA-8852798) C5b alpha' [extracellular region] (R-HSA-173672) C5 alpha chain [extracellular region] (R-HSA-173673) C5 beta chain [extracellular region] (R-HSA-173675) C5a [extracellular region] (R-HSA-173677)	0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:Q8IVQ6 ZDHHC21	1	ZDHHC21 [Golgi membrane] (R-HSA-203757)	0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126):FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	5
UniProt:Q9Y5Y5 PEX16	2	PEX16 [peroxisomal membrane] (R-HSA-9603805) PEX16 [cytosol] (R-HSA-9603790)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3

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