Reactome | VRK2 [mitochondrial outer membrane]

VRK2 [mitochondrial outer membrane]

Stable Identifier

R-HSA-9715102

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q86Y07 VRK2

Gene Names

VRK2

Chain

chain:1-508

Reference Genes

BioGPS Gene:7444 VRK2

COSMIC (genes):VRK2 VRK2

CTD Gene:7444 VRK2

dbSNP Gene:7444 VRK2

ENSEMBL:ENSG00000028116 VRK2

HGNC:12719 VRK2

KEGG:hsa:7444 VRK2

Monarch:7444 VRK2

NCBI Gene:7444 VRK2

OMIM:602169 VRK2

UCSC:Q86Y07 VRK2

Reference Transcript

Participates

as a candidate of

RHOD mitochondrial outer membrane effectors [cytosol] (Homo sapiens)

Other forms of this molecule

VRK2 [endoplasmic reticulum membrane]

Inferred To

VRK2 [mitochondrial outer membrane] (Bos taurus)

VRK2 [mitochondrial outer membrane] (Caenorhabditis elegans)

VRK2 [mitochondrial outer membrane] (Canis familiaris)

VRK2 [mitochondrial outer membrane] (Drosophila melanogaster)

VRK2 [mitochondrial outer membrane] (Gallus gallus)

VRK2 [mitochondrial outer membrane] (Mus musculus)

VRK2 [mitochondrial outer membrane] (Sus scrofa)

Vrk2 [mitochondrial outer membrane] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

2276

OpenTargets

ENSG00000028116

ENSEMBL

ENST00000412104, ENST00000648897, ENST00000440705, ENSP00000398323, ENSP00000497378, ENST00000340157, ENSG00000028116, ENSP00000342381, ENST00000435505, ENSP00000408002, ENST00000417641, ENSP00000402375, ENSP00000404156

ZINC - FDA approved

VRK2_HUMAN

ZINC - Substances

VRK2_HUMAN

ZINC target

Q86Y07

PRO

Q86Y07

PDB

8Q1Z, 5UU1, 6NCG, 2V62, 9FET

ZINC - Investigational

VRK2_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000028116-VRK2

GeneCards

VRK2

Pharos - Targets

Q86Y07

ZINC - Predictions - Purchasable

VRK2_HUMAN

HMDB Protein

HMDBP01323

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.524	2
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.483	3

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