Reactome | CPSF7 [cytosol]

CPSF7 [cytosol]

Stable Identifier

R-HSA-9715140

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB1 GTPase cycle (Homo sapiens)
        
        RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        CPSF7 [cytosol] (Homo sapiens)
        
        RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        CPSF7 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N684 CPSF7

Gene Names

CPSF7

Chain

chain:1-471

Reference Genes

BioGPS Gene:79869 CPSF7

COSMIC (genes):CPSF7 CPSF7

CTD Gene:79869 CPSF7

dbSNP Gene:79869 CPSF7

ENSEMBL:ENSG00000149532.16 CPSF7

HGNC:30098 CPSF7

KEGG Gene (Homo sapiens):79869 CPSF7

Monarch:79869 CPSF7

NCBI Gene:79869 CPSF7

UCSC:Q8N684 CPSF7

Reference Transcript

Other Identifiers

0003440040

11739095_a_at

11739096_s_at

217866_PM_at

217866_at

3375341

3375342

3375343

3375344

3375345

3375346

3375355

3375356

3375358

3375360

3375361

3375362

3375363

3375364

3375365

3375366

3375368

3375373

3375376

3375377

3375378

3375379

3375380

3375381

54710_at

58070_at

7948574

79869

A_23_P116376

A_33_P3309039

GE86897

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005847

GO:0005849

GO:0006397

GO:0016020

GO:0016071

GO:0031124

GO:0032991

GO:0043226

GO:0051262

GO:0051290

GO:0065003

GO:0098789

GO:0110104

GO:1990120

HMNXSV003015534

HMNXSV003022367

ILMN_1680494

PH_hs_0025976

TC11001853.hg

g13376196_3p_at

Participates

as a candidate of

RHOBTB1 interacting proteins [cytosol] (Homo sapiens)

Other forms of this molecule

CPSF7 [nucleoplasm]

Inferred To

cpsf7 [cytosol] (Xenopus tropicalis)

Cpsf7 [cytosol] (Mus musculus)

Cpsf7 [cytosol] (Rattus norvegicus)

CPSF7 [cytosol] (Bos taurus)

CPSF7 [cytosol] (Canis familiaris)

CPSF7 [cytosol] (Gallus gallus)

CPSF7 [cytosol] (Sus scrofa)

Cpsf6 [cytosol] (Drosophila melanogaster)

cpsf6 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_079087.3, XP_011543560.1, NP_001136037.1, NP_001129512.1, XP_011543561.1, XP_005274356.1

OpenTargets

ENSG00000149532

HPA

ENSG00000149532-CPSF7

GeneCards

Q8N684

Ensembl

ENST00000448745, ENST00000394888, ENST00000439958, ENST00000340437, ENSP00000407394, ENSP00000397203, ENSP00000378352, ENSP00000345412, ENSG00000149532

PRO

Q8N684

Pharos - Targets

Q8N684

PDB

3N9U

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.666	4
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P26368 U2AF2	1	U2AF2 [nucleoplasm] (R-HSA-71987)	0.508	2

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