Reactome | TRPM5 transports Na+ from the extracellular region to the cytosol

TRPM5 transports Na+ from the extracellular region to the cytosol

Stable Identifier

R-HSA-9717395

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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TRPM5 transports Na+ from the extracellular region to the cytosol

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TRPM5 is activated by calcium ions and passively transports monovalent cations across the plasma membrane, resulting in depolarization of the cell (Prawitt et al. 2003). In mice, Trpm4 and Trpm5 are involved in sodium signals in type II taste cells and are required for perception of sweet, bitter, and umami tastes (Dutta Banik et al. 2018). TRPM5 is more sensitive to calcium than TRPM4 is (inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
14634208	TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i Fleig, A, Penner, R, Monteilh-Zoller, MK, Spangenberg, C, Zabel, B, Prawitt, D, Brixel, L	Proc. Natl. Acad. Sci. U.S.A.	2003