Reactome | BCL2A1 [cytosol]

BCL2A1 [cytosol]

Stable Identifier

R-HSA-9725307

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Bcl-2-related protein A1, B2LA1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
        
        NPM1-ALK-dependent BCL2A1 gene expression (Homo sapiens)
        
        BCL2A1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16548 BCL2A1

Gene Names

BCL2A1, BCL2L5, BFL1, GRS, HBPA1

Chain

chain:1-175

Reference Genes

BioGPS Gene:597 BCL2A1

COSMIC (genes):BCL2A1 BCL2A1

CTD Gene:597 BCL2A1

dbSNP Gene:597 BCL2A1

ENSEMBL:ENSG00000140379 BCL2A1

ENSEMBL_homo_sapiens_GENE:ENSG00000140379.9 BCL2A1

HGNC:991 BCL2A1

KEGG Gene (Homo sapiens):597 BCL2A1

Monarch:597 BCL2A1

NCBI Gene:597 BCL2A1

OMIM:601056 BCL2A1

UCSC:Q16548 BCL2A1

Reference Transcript

Other Identifiers

11730096_a_at

16812344

2002_s_at

205681_PM_at

205681_at

3635199

3635200

3635202

3635205

3635206

3635207

597

7990818

A_23_P152002

GE62993

GO:0001836

GO:0005215

GO:0005515

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0006915

GO:0007005

GO:0008053

GO:0008630

GO:0012501

GO:0015267

GO:0023052

GO:0042803

GO:0042981

GO:0043065

GO:0043066

GO:0043226

GO:0046982

GO:0055085

GO:0097192

ILMN_1769229

PH_hs_0012664

TC15001719.hg

U29680_at

g10442005_3p_s_at

g4757839_3p_at

Participates

as an output of

Cross References

ZINC - Investigational

B2LA1_HUMAN

RefSeq

NP_001108207.1, NP_004040.1

OpenTargets

ENSG00000140379

ZINC - Substances

B2LA1_HUMAN

HPA

ENSG00000140379-BCL2A1

GeneCards

Q16548

ZINC target

Q16548

Ensembl

ENSG00000140379, ENSP00000267953, ENSP00000335250, ENST00000267953, ENST00000335661

PRO

Q16548

Pharos - Targets

Q16548

ZINC - Predictions - Purchasable

B2LA1_HUMAN

PDB

6RJP, 5WHI, 3MQP, 6E3I, 5UUP, 6MBB, 6VO4, 5UUK, 5WHH, 5UUL, 6MBC, 4ZEQ, 6E3J, 3I1H, 2VM6

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13323 BIK			0.781	10
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.718	6
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.683	4
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:Q5HYN5 CT451			0.556	3
UniProt:O14745 NHRF1			0.488	2