TP53 R342P [nucleoplasm]

Stable Identifier
R-HSA-9726101
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
TP53 R342P [nucleoplasm] icon
Locations in the PathwayBrowser
Literature References
External Reference Information
External Reference
Gene Names
TP53, P53
Chain
chain:1-393
Participates
Other forms of this molecule
Modified Residues
Name
L-arginine 342 replaced with L-proline
Coordinate
342
PsiMod
A protein modification that effectively removes or replaces an L-arginine.
A protein modification that effectively converts a source amino acid residue to L-proline.
Disease
Name Identifier Synonyms
prostate adenocarcinoma DOID:2526 adenocarcinoma of prostate (disorder), prostate adenocarcinoma
endometrial carcinoma DOID:2871 carcinoma of the Endometrium, endometrioid carcinoma of female Reproductive system, endometrioid carcinoma
lung adenocarcinoma DOID:3910 nonsmall cell adenocarcinoma
colon adenocarcinoma DOID:234 adenocarcinoma of the colon, adenocarcinoma of colon, Colonic adenocarcinoma
adrenocortical carcinoma DOID:3948 carcinoma of the Adrenal cortex, Adrenal cortical carcinoma
thyroid gland anaplastic carcinoma DOID:0080522 anaplastic thyroid carcinoma
salivary gland carcinoma DOID:0050904
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
liver carcinoma DOID:686 Liver and Intrahepatic bile duct carcinoma
renal Wilms' tumor DOID:5176 nonanaplastic renal wilms tumor, Nonanaplastic renal Wilm's tumor
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
ovarian cancer DOID:2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
brain ependymoma DOID:7497 Ependymal tumor of brain, Ependymoma of brain
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
osteosarcoma DOID:3347 osteoid sarcoma, Skeletal sarcoma, Osteogenic sarcoma, bone tissue neoplasm
astrocytoma DOID:3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
breast ductal carcinoma DOID:3007 duct carcinoma
Cross References
COSMIC
Interactors (233)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q00987 MDM2  11 0.995 117
 UniProt:P04637 TP53  20 0.98 33
 UniProt:Q09472 EP300  5 0.976 22
 IntAct:EBI-4399559 UBIQ      0.973 21
 UniProt:P03070 LT      0.97 25
 UniProt:Q93009 USP7  2 0.969 23
 UniProt:O15151 MDM4  5 0.966 22
 UniProt:P0CG48 UBC  20 0.96 15
 UniProt:Q92793 CREBBP  4 0.96 17
 UniProt:Q96EB6 SIRT1  1 0.957 18
 IntAct:EBI-1550784 CDKN1A      0.929 22
 UniProt:Q8WTS6 SETD7  1 0.922 11
 UniProt:Q14999 CUL7  1 0.919 18
 UniProt:Q8IWT3 CUL9  2 0.917 15
 UniProt:Q13625 TP53BP2  1 0.903 9
 UniProt:Q96PM5 RCHY1  2 0.892 13
 UniProt:Q07817-1 BCL2L1      0.881 26
 UniProt:Q12888-1 TP53BP1      0.879 17
 UniProt:Q12888 TP53BP1  3 0.87 8
 UniProt:P26447 S10A4      0.848 9
 UniProt:Q13526 PIN1  2 0.846 14
 UniProt:P45481 Crebbp  4 0.845 10
 UniProt:P06463 VE6      0.84 5
 UniProt:Q9UER7 DAXX  13 0.84 12
 UniProt:Q15672 TWIST1  1 0.817 10
 UniProt:Q8WUF5 PPP1R13L  1 0.815 12
 UniProt:P38646 HSPA9  6 0.811 6
 UniProt:P03126 VE6      0.807 5
 UniProt:Q9NRG4 SMYD2  1 0.806 6
 UniProt:P38936 CDKN1A  5 0.778 5
 UniProt:O14641 DVL2  5 0.778 6
 UniProt:Q05086 UBE3A  1 0.77 6
 UniProt:Q923E4 Sirt1  2 0.766 4
 UniProt:Q99986 VRK1  2 0.761 11
 UniProt:Q05397 PTK2  11 0.751 13
 UniProt:P09874 PARP1  4 0.75 5
 UniProt:P09429 HMGB1  5 0.74 9
 UniProt:P31947 SFN  1 0.738 5
 UniProt:P63279 UBE2I  9 0.737 5
 UniProt:P53350 PLK1  4 0.737 6
 UniProt:Q9NPI1 BRD7  1 0.729 9
 UniProt:P43356 MAGA2      0.729 7
 UniProt:O14503 BHLHE40  1 0.728 11
 UniProt:Q8N3Y1 FBXW8  1 0.725 7
 UniProt:P19784 CSNK2A2  2 0.725 4
 UniProt:Q99615 DNAJC7  2 0.725 5
 UniProt:Q9UBL3 ASH2L  1 0.723 8
 UniProt:P63165 SUMO1  11 0.722 3
 UniProt:P32776  1 0.719 7
 UniProt:P32780 GTF2H1  1 0.719 12
 UniProt:Q8NHY2 RFWD2  3 0.717 5
 UniProt:Q96KB5 TOPK      0.715 7
 UniProt:P13693 TCTP      0.715 7
 UniProt:Q16666-2 IFI16      0.715 6
 UniProt:Q13547 HDAC1  2 0.713 7
 UniProt:Q9H2X6 HIPK2  3 0.713 3
 UniProt:P42858 HTT  1 0.709 19
 UniProt:P13569 CFTR  17 0.706 18
 UniProt:P29590 PML  5 0.7 4
 UniProt:Q9BUJ2 HNRNPUL1  1 0.697 12
 UniProt:O95376 ARIH2  1 0.691 5
 UniProt:P61964 WDR5  1 0.69 5
 UniProt:Q15291 RBBP5  1 0.69 5
 UniProt:P02829  11 0.678 8
 UniProt:Q9NRR4 DROSHA  1 0.677 5
 UniProt:P06703 S10A6      0.676 3
 UniProt:P29034 S10A2      0.676 4
 UniProt:P06748 NPM1  11 0.676 6
 UniProt:P68400 CSNK2A1  2 0.675 3
 UniProt:Q15796 SMAD2  20 0.674 7
 UniProt:P63104 YWHAZ  2 0.669 3
 UniProt:Q96M61 MAGBI      0.668 3
 UniProt:P31948 STIP1  1 0.666 4
 UniProt:P04792 HSBP1  3 0.665 3
 UniProt:O60341-1 KDM1A      0.664 6
 UniProt:P26663-PRO_0000037536      0.664 9
 UniProt:P48643 CCT5  1 0.659 3
 UniProt:P49841 GSK3B  4 0.658 3
 UniProt:P03120 VE2      0.658 3
 UniProt:P17844 DDX5  4 0.656 6
 UniProt:P51587 BRCA2  20 0.655 7
 UniProt:Q13362 PPP2R5C  3 0.65 4
 UniProt:Q06587 RING1  1 0.65 7
 UniProt:Q14191 WRN  2 0.647 5
 UniProt:O96017 CHEK2  3 0.646 3
 UniProt:Q9BV47 DUS26      0.645 9
 UniProt:Q9Y618 NCOR2  2 0.645 7
 UniProt:Q86XK2 FBXO11  1 0.645 4
 UniProt:Q06330 RBPJ  1 0.645 5
 UniProt:Q92569 PIK3R3  2 0.644 5
 UniProt:Q9UPR3 SMG5  1 0.643 3
 UniProt:P61981 YWHAG  1 0.643 5
 IntAct:EBI-1550787 MDM2      0.643 3
 UniProt:O95816 BAG2  1 0.643 4
 UniProt:Q6NYC1 JMJD6  1 0.639 7
 UniProt:P30405 PPIF      0.639 4
 UniProt:Q96FW1 OTUB1  2 0.632 8
 UniProt:P49757 NUMB  1 0.632 5
 UniProt:Q9Y3T9 NOC2L  1 0.632 8
 UniProt:P30153 PPP2R1A  2 0.628 3
 UniProt:P04019 VE6      0.623 2
 UniProt:Q8N488 RYBP  1 0.623 4
 UniProt:Q8N726 CDKN2A  12 0.623 3
 UniProt:P23297 S100A1  1 0.623 3
 UniProt:Q6PCD5 RFWD3      0.623 5
 UniProt:P04271 S100B  1 0.623 3
 UniProt:P35232 PHB  2 0.619 6
 UniProt:Q9Y265 RUVBL1  1 0.619 10
 UniProt:Q86TM6 SYVN1  1 0.61 5
 UniProt:O14920 IKBKB  3 0.609 2
 UniProt:Q9BWC9 CC106      0.608 3
 UniProt:P41235 HNF4A  1 0.604 3
 UniProt:P15036 ETS2  2 0.602 4
 UniProt:P89055 P89055      0.602 6
 UniProt:Q9UHC7 MKRN1  2 0.602 8
 UniProt:Q9UHH9 IP6K2  1 0.602 4
 UniProt:Q05655 PRKCD  12 0.602 4
 UniProt:Q9P0U4 CXXC1  1 0.597 7
 UniProt:Q13155 AIMP2  1 0.593 6
 UniProt:Q96SB4 SRPK1  2 0.591 3
 UniProt:Q06945 SOX4  1 0.591 4
 UniProt:Q8TAQ5 ZNF420  2 0.591 4
 UniProt:Q9UBF1 MAGC2      0.591 3
 UniProt:O60285 NUAK1  2 0.591 5
 UniProt:P23396 RPS3  2 0.59 4
 UniProt:Q96ST3 SIN3A  2 0.589 2
 UniProt:Q9H3D4 TP63  1 0.589 5
 UniProt:O14980 XPO1  2 0.589 3
 UniProt:P08047 SP1  1 0.589 6
 UniProt:P61978 HNRNPK  2 0.589 2
 UniProt:P22736 NR4A1  2 0.581 6
 UniProt:Q96GM8 TOE1      0.577 3
 UniProt:P61289 PSME3  1 0.576 7
 UniProt:O43847 NRDC      0.576 6
 UniProt:O75925 PIAS1  1 0.571 4
 UniProt:P15884 TCF4  1 0.564 2
 UniProt:P25208 NFYB  1 0.564 6
 UniProt:P10415 BCL2  1 0.564 5
 UniProt:P06748-1 NPM1      0.564 3
 UniProt:Q9H7Z6 KAT8  1 0.564 2
 UniProt:P19338 NCL  3 0.558 2
 UniProt:P00519 ABL1  6 0.558 2
 UniProt:Q7Z412 PEX26  2 0.556 3
 UniProt:P13473-2 P134732      0.556 3
 IntAct:EBI-25865403 EHD27213144      0.556 3
 UniProt:Q15424 SAFB  3 0.556 5
 UniProt:P21333-2 FLNA      0.556 3
 UniProt:A0A6Q8PF08 A0A6Q8PF08      0.556 3
 UniProt:P55212 CASP6  5 0.556 3
 IntAct:EBI-16429055 CCSB ISOFORM ID      0.556 3
 UniProt:P17676 CEBPB  3 0.556 4
 UniProt:P09936 UCHL1  1 0.556 3
 UniProt:P46821 MAP1B  1 0.556 6
 UniProt:P04183 TK1  1 0.553 2
 UniProt:Q9BQA5 HINFP      0.553 2
 UniProt:Q99608 NDN  1 0.547 4
 UniProt:P55060 XPO2      0.544 5
 UniProt:Q8R5A0  1 0.544 3
 UniProt:O60936 NOL3      0.544 3
 UniProt:Q9PST7 Q9PST7      0.544 3
 UniProt:P04731 MT1A  1 0.544 3
 UniProt:P33763 S10A5      0.544 2
 UniProt:P29066  6 0.544 3
 UniProt:P25815 S100P  2 0.544 2
 UniProt:P31949 S100A11  2 0.544 2
 UniProt:Q9H9J4-2 USP42      0.544 2
 UniProt:P38398 BRCA1  20 0.544 2
 UniProt:P11473 VDR  2 0.537 6
 UniProt:P23511 NFYA  1 0.537 11
 UniProt:P34931 HSPA1L  2 0.536 2
 UniProt:O43524 FOXO3  11 0.536 2
 UniProt:O15047 SETD1A  1 0.532 4
 UniProt:P27958-PRO_0000037566      0.528 2
 UniProt:Q99832 CCT7  1 0.527 2
 UniProt:Q9NTK5 OLA1  2 0.527 2
 UniProt:P40227 CCT6A  1 0.527 2
 UniProt:Q9H0W5 CCDC8  1 0.527 2
 UniProt:Q8TBX8 PIP4K2C  2 0.527 2
 UniProt:P50991 CCT4  1 0.527 2
 UniProt:O75147 OBSL1  1 0.527 2
 IntAct:EBI-1550792 TP53I3      0.527 3
 UniProt:Q15831 STK11  2 0.527 2
 UniProt:O43189 PHF1  1 0.527 2
 UniProt:P17987 TCP1  1 0.527 2
 UniProt:P78371 CCT2  3 0.527 2
 UniProt:P49368 CCT3  1 0.527 2
 UniProt:P46777 RPL5  1 0.527 2
 UniProt:Q96PZ2 F111A      0.527 4
 UniProt:P06400 RB1  20 0.527 2
 UniProt:Q9UL15 BAG5  1 0.527 4
 UniProt:Q9UNE7 STUB1  1 0.527 3
 IntAct:EBI-6620336 CD44      0.525 2
 UniProt:Q8IZD2 KMT2E      0.524 4
 UniProt:O95352-2 ATG7      0.524 4
 UniProt:Q7Z6Z7 HUWE1  4 0.524 3
 UniProt:Q15648 MED1  1 0.524 3
 UniProt:Q7L7W2 Q7L7W2      0.524 2
 UniProt:P61978-2 HNRNPK      0.524 2
 UniProt:O95863 SNAI1  1 0.524 2
 UniProt:P26687 Twist1  2 0.524 4
 UniProt:Q96PU4 UHRF2  1 0.524 3
 UniProt:Q08619 IFI5B      0.524 2
 UniProt:Q92841 DDX17  2 0.524 3
 UniProt:P36873-1 PPP1CC      0.524 2
 UniProt:Q03701 CEBPZ      0.524 2
 UniProt:Q12772 SREBF2  5 0.524 3
 UniProt:O15169 AXIN1  11 0.524 4
 UniProt:O15164 TRIM24  4 0.524 3
 UniProt:Q15466 NR0B2  1 0.524 3
 UniProt:P11274 BCR  4 0.519 2
 UniProt:Q16363 LAMA4  1 0.519 2
 UniProt:O75928 PIAS2  1 0.519 2
 UniProt:Q8N2W9 PIAS4  2 0.508 2
 UniProt:Q9BX70 BTBD2      0.508 2
 UniProt:P51114 FXR1  2 0.508 2
 UniProt:Q86Z02 HIPK1  1 0.508 2
 UniProt:Q9NZN9 AIPL1      0.508 2
 UniProt:O75970 MPDZ      0.499 3
 UniProt:P49407 ARRB1  6 0.499 5
 UniProt:Q8TEW0 PARD3  3 0.499 3
 UniProt:Q8N9N5 BANP  1 0.499 3
 UniProt:Q60953-2 PML      0.499 3
 UniProt:Q92993 KAT5  1 0.499 3
 UniProt:P29590-5 PML      0.491 2
 UniProt:P16885 PLCG2  8 0.488 2
 UniProt:O43741 PRKAB2  2 0.488 2
 UniProt:P24830 VE2      0.488 2
 UniProt:Q96CJ1 EAF2  1 0.488 2
 UniProt:Q16666 IFI16  1 0.488 2
 UniProt:O70445  4 0.463 2
 UniProt:Q8QVZ0 Q8QVZ0      0.463 2
 IntAct:EBI-1800051 CDKN1A      0.462 2
 UniProt:Q7Z2E3 APTX      0.462 4
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