TP53 R342P [nucleoplasm]

Stable Identifier
R-HSA-9726101
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
TP53 R342P [nucleoplasm] icon
Locations in the PathwayBrowser
Literature References
External Reference Information
External Reference
Gene Names
TP53, P53
Chain
chain:1-393
Other Identifiers
0005670112
11738335_x_at
11748319_x_at
11748599_a_at
11750514_x_at
11751536_a_at
11751537_x_at
16840732
1939_at
1974_s_at
201746_at
211300_s_at
31618_at
3743907
3743908
3743909
3743912
3743913
3743915
3743917
3743918
3743919
3743920
3743922
3743923
3743924
3743925
3743926
3743933
7157
8012257
A_23_P26810
A_33_P3315764
GE58227
GO:0000122
GO:0000278
GO:0000733
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001046
GO:0001085
GO:0001094
GO:0001216
GO:0001228
GO:0001701
GO:0001756
GO:0001836
GO:0002020
GO:0002039
GO:0002244
GO:0002309
GO:0002326
GO:0002360
GO:0002376
GO:0002931
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0003723
GO:0003729
GO:0003730
GO:0005507
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005657
GO:0005667
GO:0005669
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005783
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005975
GO:0006091
GO:0006259
GO:0006289
GO:0006302
GO:0006355
GO:0006357
GO:0006464
GO:0006606
GO:0006810
GO:0006913
GO:0006914
GO:0006915
GO:0006950
GO:0006974
GO:0006977
GO:0006978
GO:0006979
GO:0006983
GO:0007005
GO:0007049
GO:0007050
GO:0007165
GO:0007179
GO:0007265
GO:0007369
GO:0007406
GO:0007417
GO:0007507
GO:0007568
GO:0007569
GO:0007623
GO:0008104
GO:0008134
GO:0008150
GO:0008156
GO:0008219
GO:0008270
GO:0008283
GO:0008285
GO:0008340
GO:0009056
GO:0009058
GO:0009299
GO:0009303
GO:0009411
GO:0009651
GO:0009790
GO:0009792
GO:0010165
GO:0010332
GO:0010628
GO:0010629
GO:0010666
GO:0012501
GO:0015031
GO:0016032
GO:0016363
GO:0016579
GO:0016604
GO:0016605
GO:0019221
GO:0019899
GO:0019901
GO:0019903
GO:0021549
GO:0022607
GO:0030154
GO:0030234
GO:0030308
GO:0030330
GO:0030512
GO:0030971
GO:0031065
GO:0031497
GO:0031571
GO:0031625
GO:0032991
GO:0033077
GO:0033209
GO:0034103
GO:0034613
GO:0034641
GO:0034644
GO:0035033
GO:0035035
GO:0035264
GO:0035690
GO:0035794
GO:0035861
GO:0036003
GO:0040007
GO:0042127
GO:0042149
GO:0042493
GO:0042771
GO:0042802
GO:0042826
GO:0042981
GO:0043065
GO:0043066
GO:0043153
GO:0043167
GO:0043226
GO:0043504
GO:0043516
GO:0043523
GO:0043525
GO:0043621
GO:0044281
GO:0044403
GO:0045861
GO:0045892
GO:0045893
GO:0045899
GO:0045930
GO:0045944
GO:0046677
GO:0046827
GO:0046872
GO:0046982
GO:0047485
GO:0048147
GO:0048511
GO:0048512
GO:0048539
GO:0048568
GO:0048646
GO:0048856
GO:0050731
GO:0050821
GO:0051087
GO:0051097
GO:0051262
GO:0051276
GO:0051402
GO:0051721
GO:0051726
GO:0051974
GO:0060218
GO:0060260
GO:0060333
GO:0060411
GO:0061024
GO:0061419
GO:0062100
GO:0065003
GO:0070059
GO:0070243
GO:0070245
GO:0070266
GO:0071158
GO:0071456
GO:0071479
GO:0071480
GO:0071494
GO:0071850
GO:0072331
GO:0072332
GO:0072717
GO:0090200
GO:0090343
GO:0090399
GO:0090403
GO:0097193
GO:0097252
GO:0097371
GO:0097718
GO:1900119
GO:1900740
GO:1901525
GO:1901796
GO:1902108
GO:1902253
GO:1902749
GO:1902895
GO:1903799
GO:1903800
GO:1904024
GO:1905856
GO:1990144
GO:1990248
GO:1990440
GO:1990841
GO:2000269
GO:2000378
GO:2000379
GO:2000772
GO:2001244
HMNXSV003011219
ILMN_1779356
M22898_at
PH_hs_0019846
TC17001094.hg
TC17002468.hg
g189478_3p_a_at
g8400737_3p_at
g8400737_3p_x_at
Participates
Other forms of this molecule
Modified Residues
Name
L-arginine 342 replaced with L-proline
Coordinate
342
PsiMod
A protein modification that effectively removes or replaces an L-arginine.
A protein modification that effectively converts a source amino acid residue to L-proline.
Disease
Name Identifier Synonyms
prostate adenocarcinoma DOID:2526 adenocarcinoma of prostate (disorder), prostate adenocarcinoma
osteosarcoma DOID:3347 osteoid sarcoma, Skeletal sarcoma, Osteogenic sarcoma, bone tissue neoplasm
brain ependymoma DOID:7497 Ependymal tumor of brain, Ependymoma of brain
salivary gland carcinoma DOID:0050904
liver carcinoma DOID:686 Liver and Intrahepatic bile duct carcinoma
endometrial carcinoma DOID:2871 carcinoma of the Endometrium, endometrioid carcinoma of female Reproductive system, endometrioid carcinoma
ovarian cancer DOID:2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
thyroid gland anaplastic carcinoma DOID:0080522 anaplastic thyroid carcinoma
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
astrocytoma DOID:3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
renal Wilms' tumor DOID:5176 nonanaplastic renal wilms tumor, Nonanaplastic renal Wilm's tumor
breast ductal carcinoma DOID:3007 duct carcinoma
adrenocortical carcinoma DOID:3948 carcinoma of the Adrenal cortex, Adrenal cortical carcinoma
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
lung adenocarcinoma DOID:3910 nonsmall cell adenocarcinoma
colon adenocarcinoma DOID:234 adenocarcinoma of the colon, adenocarcinoma of colon, Colonic adenocarcinoma
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
OpenTargets
ZINC - Substances
ZINC target
PRO
GlyGen
COSMIC
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
Interactors (211)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q00987 MDM2  11 0.994 98
 UniProt:P04637 TP53  20 0.98 33
 UniProt:Q09472 EP300  5 0.976 22
 IntAct:EBI-4399559 UBIQ      0.973 21
 UniProt:P03070 LT      0.97 25
 UniProt:Q93009 USP7  2 0.968 22
 UniProt:O15151 MDM4  5 0.964 19
 UniProt:P0CG48 UBC  20 0.96 15
 UniProt:Q92793 CREBBP  3 0.96 17
 UniProt:Q96EB6 SIRT1  1 0.957 18
 IntAct:EBI-1550784 CDKN1A      0.929 22
 UniProt:Q8WTS6 SETD7  1 0.922 11
 UniProt:Q13625 TP53BP2  1 0.903 9
 UniProt:Q96PM5 RCHY1  2 0.892 13
 UniProt:Q07817-1 BCL2L1      0.881 26
 UniProt:Q12888-1 TP53BP1      0.879 17
 UniProt:P26447 S10A4      0.848 9
 UniProt:Q13526 PIN1  2 0.846 14
 UniProt:P45481 Crebbp  4 0.845 10
 UniProt:P06463 VE6      0.84 5
 UniProt:Q9UER7 DAXX  13 0.84 12
 UniProt:Q12888 TP53BP1  3 0.829 6
 UniProt:Q15672 TWIST1  1 0.817 10
 UniProt:Q8WUF5 PPP1R13L  1 0.815 12
 UniProt:P38646 HSPA9  6 0.811 6
 UniProt:P03126 VE6      0.807 5
 UniProt:Q9NRG4 SMYD2  1 0.806 6
 UniProt:O14641 DVL2  5 0.778 6
 UniProt:Q05086 UBE3A  1 0.77 6
 UniProt:Q923E4 Sirt1  2 0.766 4
 UniProt:Q99986 VRK1  2 0.761 11
 UniProt:Q05397 PTK2  11 0.751 13
 UniProt:P09874 PARP1  4 0.75 5
 UniProt:P09429 HMGB1  5 0.74 9
 UniProt:P63279 UBE2I  8 0.737 5
 UniProt:P53350 PLK1  4 0.737 6
 UniProt:Q9NPI1 BRD7  1 0.729 9
 UniProt:P43356 MAGA2      0.729 7
 UniProt:O14503 BHLHE40  1 0.728 11
 UniProt:Q14999 CUL7  1 0.723 5
 UniProt:P63165 SUMO1  20 0.722 3
 UniProt:P32776  1 0.719 7
 UniProt:P32780 GTF2H1  1 0.719 12
 UniProt:Q8NHY2 COP1  3 0.717 5
 UniProt:Q8IWT3 CUL9  2 0.716 4
 UniProt:Q96KB5 TOPK      0.715 7
 UniProt:P13693 TCTP      0.715 7
 UniProt:Q16666-2 IFI16      0.715 6
 UniProt:Q13547 HDAC1  2 0.713 7
 UniProt:Q9H2X6 HIPK2  3 0.713 3
 UniProt:P42858 HTT  1 0.709 19
 UniProt:P29590 PML  5 0.7 4
 UniProt:Q9BUJ2 HNRNPUL1  1 0.697 12
 UniProt:O95376 ARIH2  1 0.691 5
 UniProt:P61964 WDR5  1 0.69 5
 UniProt:Q15291 RBBP5  1 0.69 5
 UniProt:P02829  11 0.678 8
 UniProt:Q9NRR4 DROSHA  1 0.677 5
 UniProt:P06703 S10A6      0.676 3
 UniProt:P29034 S10A2      0.676 4
 UniProt:P06748 NPM1  10 0.676 6
 UniProt:Q15796 SMAD2  20 0.674 7
 UniProt:Q96M61 MAGBI      0.668 3
 UniProt:P31947 SFN  1 0.667 4
 UniProt:P04792 HSPB1  3 0.665 3
 UniProt:O60341-1 KDM1A      0.664 6
 UniProt:P26663-PRO_0000037536      0.664 9
 UniProt:P49841 GSK3B  4 0.658 3
 UniProt:P03120 VE2      0.658 3
 UniProt:P17844 DDX5  4 0.656 6
 UniProt:P51587 BRCA2  2 0.655 7
 UniProt:Q13362 PPP2R5C  3 0.65 4
 UniProt:Q06587 RING1  1 0.65 7
 UniProt:Q14191 WRN  2 0.647 5
 UniProt:O96017 CHEK2  3 0.646 3
 UniProt:Q9BV47 DUS26      0.645 9
 UniProt:Q9Y618 NCOR2  2 0.645 7
 UniProt:Q86XK2 FBXO11  1 0.645 4
 UniProt:Q06330 RBPJ  1 0.645 5
 UniProt:Q92569 PIK3R3  2 0.644 5
 UniProt:P61981 YWHAG  1 0.643 5
 IntAct:EBI-1550787 MDM2      0.643 3
 UniProt:Q9UBL3 ASH2L  1 0.643 7
 UniProt:Q6NYC1 JMJD6  1 0.639 7
 UniProt:P30405 PPIF      0.639 4
 UniProt:Q96FW1 OTUB1  2 0.632 8
 UniProt:P49757 NUMB  1 0.632 5
 UniProt:Q9Y3T9 NOC2L  1 0.632 8
 UniProt:P30153 PPP2R1A  2 0.628 3
 UniProt:P04019 VE6      0.623 2
 UniProt:P04271 S100B  1 0.623 3
 UniProt:P23297 S100A1  1 0.623 3
 UniProt:Q6PCD5 RFWD3      0.623 5
 UniProt:Q9Y265 RUVBL1  1 0.619 10
 UniProt:P35232 PHB  2 0.619 6
 UniProt:P38936 CDKN1A  5 0.616 3
 UniProt:Q86TM6 SYVN1  1 0.61 5
 UniProt:O14920 IKBKB  3 0.609 2
 UniProt:Q9BWC9 CC106      0.608 3
 UniProt:P15036 ETS2  2 0.602 4
 UniProt:Q9UHC7 MKRN1  2 0.602 8
 UniProt:P89055 P89055      0.602 6
 UniProt:Q9UHH9 IP6K2  1 0.602 4
 UniProt:Q05655 PRKCD  12 0.602 4
 UniProt:Q9P0U4 CXXC1  1 0.597 7
 UniProt:Q13155 AIMP2  1 0.593 6
 UniProt:Q96SB4 SRPK1  1 0.591 3
 UniProt:Q06945 SOX4  1 0.591 4
 UniProt:Q8TAQ5 ZNF420  2 0.591 4
 UniProt:Q9UBF1 MAGC2      0.591 3
 UniProt:O60285 NUAK1  2 0.591 5
 UniProt:P23396 RPS3  2 0.59 4
 UniProt:P61978 HNRNPK  2 0.589 2
 UniProt:Q96ST3 SIN3A  2 0.589 2
 UniProt:Q9H3D4 TP63  1 0.589 5
 UniProt:P08047 SP1  1 0.589 6
 UniProt:O14980 XPO1  2 0.589 3
 UniProt:P22736 NR4A1  2 0.581 6
 UniProt:Q96GM8 TOE1      0.577 3
 UniProt:P61289 PSME3  2 0.576 7
 UniProt:O43847 NRDC      0.576 6
 UniProt:O75925 PIAS1  1 0.571 4
 UniProt:P68400 CSNK2A1  2 0.571 2
 UniProt:P63104 YWHAZ  2 0.564 2
 UniProt:Q9H7Z6 KAT8  1 0.564 2
 UniProt:P15884 TCF4  1 0.564 2
 UniProt:P25208 NFYB  1 0.564 6
 UniProt:P10415 BCL2  1 0.564 5
 UniProt:P06748-1 NPM1      0.564 3
 UniProt:P19338 NCL  1 0.558 2
 UniProt:Q7Z412 PEX26  2 0.556 3
 UniProt:P13473-2 P134732      0.556 3
 IntAct:EBI-25865403 EHD27213144      0.556 3
 UniProt:Q15424 SAFB  3 0.556 5
 UniProt:P46821 MAP1B      0.556 6
 UniProt:P21333-2 FLNA      0.556 3
 UniProt:P55212 CASP6  5 0.556 3
 IntAct:EBI-16429055 CCSB ISOFORM ID      0.556 3
 UniProt:D3DTS7 D3DTS7      0.556 3
 UniProt:P17676 CEBPB  3 0.556 4
 UniProt:P31948 STIP1  1 0.556 3
 UniProt:P09936 UCHL1  1 0.556 3
 UniProt:P04183 TK1  1 0.553 2
 UniProt:Q9BQA5 HINFP      0.553 2
 UniProt:P48643 CCT5  1 0.547 2
 UniProt:P38398 BRCA1  20 0.544 2
 UniProt:P55060 XPO2      0.544 5
 UniProt:Q8R5A0  1 0.544 3
 UniProt:O60936 NOL3      0.544 3
 UniProt:Q9PST7 Q9PST7      0.544 3
 UniProt:P04731 MT1A  1 0.544 3
 UniProt:P33763 S10A5      0.544 2
 UniProt:P29066  5 0.544 3
 UniProt:P25815 S100P  2 0.544 2
 UniProt:P31949 S100A11  2 0.544 2
 UniProt:Q9H9J4-2 USP42      0.544 2
 UniProt:P11473 VDR  2 0.537 6
 UniProt:P23511 NFYA