mRNA7 is translated to protein 7a

Stable Identifier
R-HSA-9727297
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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mRNA7 is translated to protein 7a
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The open reading frame 7a of SARS-Cov-2 mRNA7 has a length of 366 nt and encodes the 121 aa preprotein 7a. After cleavage of the signal peptide, protein 7a has a length of 106 aa. Another ORF of mRNA7 has a length of 132 nt, encoding the 43 aa protein 7b (Wu et al, 2020).

In HEK 293 T cells protein 7a showed a large presence at the Golgi compartment, where it might play a role in mediating the host cell trafficking process (Lee et al, 2021).
Literature References
PubMed ID Title Journal Year
32015508 A new coronavirus associated with human respiratory disease in China

Song, ZG, Liu, Y, Yuan, ML, Tian, JH, Zhang, YL, Dai, FH, Zhang, YZ, Wu, F, Pei, YY, Chen, YM, Yu, B, Xu, L, Zheng, JJ, Zhao, S, Tao, ZW, Wang, QM, Holmes, EC, Wang, W, Hu, Y

Nature 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-04-13)
Reviewed
Gillespie, ME  (2022-05-10)
Created
Stephan, R  (2021-04-15)
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