SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins

Stable Identifier
R-HSA-9727919
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SARS-CoV-1 nucleoprotein (N) was found to coimmunoprecipitate with proteins binding to a 14-3-3 β antibody that recognized all the 14-3-3 isoforms. The binding was significantly reduced in the presence of kinase inhibitors, indicating that phosphorylation of N is necessary. Binding to 14-3-3 retains N in the cytosol (Surjit et al, 2005).
Literature References
PubMed ID Title Journal Year
16103198 The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation

Mishra, RN, Kumar, R, Reddy, MK, Chow, VT, Surjit, M, Lal, SK

J. Virol. 2005
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2021-04-16)
Reviewed
D'Eustachio, P  (2021-01-26)
Created
Stephan, R  (2021-04-19)
Cite Us!