Nucleoprotein is methylated by PRMT1

Stable Identifier
R-HSA-9729283
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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Nucleoprotein is methylated by PRMT1
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Protein arginine methyltransferase 1 (PRMT1) methylates SARS-CoV-2 nucleoprotein on two arginines (R95 and R177). This modification is required for its RNA binding capacity, since treatment with a type I PRMT inhibitor (MS023) or substitution of R95K or R177K inhibited interaction with the 5’-UTR of the SARS-CoV-2 genomic RNA. Pre-treatment of VeroE6 cells with MS023 significantly reduced SARS-CoV-2 replication (Cai et al, 2021).

Literature References
PubMed ID Title Journal Year
34029587 Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication

Richard, S, Liang, C, Wang, Z, Yu, Z, Cai, T

J Biol Chem 2021
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein-arginine omega-N asymmetric methyltransferase activity of PRMT1 [cytosol]

Physical Entity
PRMT1 [cytosol] (Homo sapiens)
Activity
protein-arginine omega-N asymmetric methyltransferase activity (GO:0035242)
This event is regulated
Negatively by
Regulator
PRMT1:type I PRMT inhibitors [cytosol] (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-04-22)
Reviewed
Acencio, ML  (2021-05-09)
Created
Stephan, R  (2021-04-28)
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