Unknown kinase phosphorylates nucleoprotein

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Phosphorylation of nucleoprotein
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Most of SARS-Cov-2 nucleocapsid phosphorylations in its S/R-rrich region are shown or proposed to be catalyzed by the host cell kinases SRPK1/2, GSK3, and CSNK1A1. However, the phosphorylation sites at S23, S79, and S183 were confirmed experimentally by three proteomics papers but the responsible kinase is unknown (Bouhaddou et al, 2020; Davidson et al, 2020; Klann et al, 2020).
Literature References
PubMed ID Title Journal Year
32723359 Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein

Williamson, MK, Ellis, J, Heesom, KJ, Lewis, PA, Matthews, DA, Zambon, M, Carroll, MW, Shoemark, D, Davidson, AD, Lewis, S, Hiscox, JA

Genome Med 2020
32877642 Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication

Ciesek, S, Cinatl, J, Tascher, G, Münch, C, Bojkova, D, Klann, K

Mol Cell 2020
32645325 The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Beltrao, P, Fischer, ER, Koh, C, Vignuzzi, M, Johnson, JR, Richards, AL, Bouhaddou, M, Melnyk, JE, Meyer, B, O'Neal, MC, Guo, JZ, Lim, JK, Shoichet, B, Dugourd, A, Hernandez-Armenta, C, Fabius, JM, McBride, T, Obernier, K, Kim, M, Leach, AR, Manners, EJ, Weigang, S, Moreno, E, Cakir, M, Soucheray, M, Cai, Y, Knerr, J, Hüttenhain, R, Patil, T, Polacco, BJ, Muralidharan, M, Hardy, A, Mathy, CJP, Nilsson-Payant, BE, Grosse, R, Quintero, D, Li, Q, Goff, M, Miorin, L, Stevenson, E, Swaney, DL, Tutuncuoglu, B, Mullins, RD, Shokat, KM, Rezelj, VV, Zhou, Y, Batra, J, Jang, G, Bouhaddou, S, Krogan, NJ, Tran, QD, Modak, M, tenOever, BR, White, KM, Dunham, A, de Wit, E, Robinot, R, Gaulton, A, Kochs, G, Xu, J, Saez-Rodriguez, J, Valdeolivas, A, García-Sastre, A, Félix, E, Vallet, T, Shi, Y, Memon, D, Gordon, DE, Broadhurst, DJ, Ulferts, S, Kaake, RM, Klippsten, S, Kortemme, T, Ott, M, Rojc, A, Chang, JCJ, Hiatt, J, Correa Marrero, M

Cell 2020
32817937 The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro

Chaparian, RR, Bulaon, DK, Anand, SK, Johnson, JL, Shobana-Ganesh, K, Trimarco, JD, Liberatore, KM, Levy, TM, Nilsson-Payant, BE, Getz, G, Beausoleil, SA, Weinstein, H, Tata, PR, Kavanagh-Williamson, M, Matthews, D, Yaron, TM, Chen, SB, Lee, G, Kerelsky, A, Lin, TY, Heesom, K, Cohen, BM, Mercadante, MN, Blenis, J, Possemato, AP, Zhu, X, Tkachev, SL, Hamele, CE, Piskounova, E, Smith, CM, Davidson, AD, Harding, AT, He, L, Heaton, BE, Jordan, TX, Burke, KN, Cantley, LC, Kastenhuber, ER, tenOever, BR, Tata, A, Aguet, F, Elemento, O, Hornbeck, PV, Schwartz, RE, Heaton, NS

bioRxiv 2020
Catalyst Activity

protein serine/threonine kinase activity of unknown kinase [cytosol]

Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
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