Reactome | SRPK1 [cytosol]

SRPK1 [cytosol]

Stable Identifier

R-HSA-9729349

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SRSF protein kinase 1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of nucleoprotein (Homo sapiens)
        
        SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)
        
        SRPK1/2 [cytosol] (Homo sapiens)
        
        SRPK1:Mg2+ [cytosol] (Homo sapiens)
        
        SRPK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96SB4 SRPK1

Gene Names

SRPK1

Chain

chain:1-655

Reference Genes

BioGPS Gene:6732 SRPK1

COSMIC (genes):SRPK1 SRPK1

CTD Gene:6732 SRPK1

dbSNP Gene:6732 SRPK1

ENSEMBL:ENSG00000096063 SRPK1

ENSEMBL_homo_sapiens_GENE:ENSG00000096063.16 SRPK1

HGNC:11305 SRPK1

KEGG Gene (Homo sapiens):6732 SRPK1

Monarch:6732 SRPK1

NCBI Gene:6732 SRPK1

OMIM:601939 SRPK1

UCSC:Q96SB4 SRPK1

Reference Transcript

RefSeq:NM_003137.4 SRPK1

Other Identifiers

1031_at

11718850_a_at

11718851_a_at

11718852_a_at

17018530

202199_PM_s_at

202199_s_at

202200_PM_s_at

202200_s_at

2770719

2951675

2951676

2951677

2951684

2951687

2951695

2951697

2951698

2951700

2951701

2951702

2951703

2951704

2951705

2951707

2951709

2951712

2951714

2951715

2951716

2951717

2951723

2951726

6732

8125941

A_23_P19543

GE58904

GO:0000166

GO:0000245

GO:0000287

GO:0000785

GO:0002376

GO:0003723

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005783

GO:0005829

GO:0005886

GO:0006325

GO:0006397

GO:0006468

GO:0007059

GO:0008380

GO:0016071

GO:0016301

GO:0016310

GO:0016363

GO:0016607

GO:0016740

GO:0022414

GO:0023052

GO:0030154

GO:0035092

GO:0035556

GO:0036211

GO:0043226

GO:0043231

GO:0045070

GO:0045071

GO:0045087

GO:0048024

GO:0048856

GO:0050684

GO:0065003

GO:0098542

GO:0106310

GO:0140096

HMNXSV003043364

Hs.75761.0.A1_3p_a_at

ILMN_1798804

PH_hs_0024102

TC06001668.hg

TC06003619.hg

U09564_at

g4507218_3p_a_at

Participates

as a component of

SRPK1:Mg2+ [cytosol] (Homo sapiens)

Other forms of this molecule

SRPK1 [nucleoplasm]

Modified Residues

Name

O-phospho-L-serine at 51

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 555

Coordinate

555

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_003128.3

ZINC - World Drugs

SRPK1_HUMAN

Guide to Pharmacology - Targets

2208

OpenTargets

ENSG00000096063

ZINC - FDA approved

SRPK1_HUMAN

ZINC - Substances

SRPK1_HUMAN

ZINC - Biogenic

SRPK1_HUMAN

ZINC target

Q96SB4

PRO

Q96SB4

PDB

7DD1, 7PQS, 5NNG, 4WUA, 7ZKS, 5XV7, 6FAD, 3BEG, 1WBP, 5MXX, 1WAK, 5MY8

ZINC - Investigational

SRPK1_HUMAN

HPA

ENSG00000096063-SRPK1

GeneCards

Q96SB4

Ensembl

ENST00000373825, ENSP00000391069, ENST00000423325, ENSG00000096063, ENSP00000362931

Pharos - Targets

Q96SB4

ZINC - Predictions - Purchasable

SRPK1_HUMAN

HMDB Protein

HMDBP08813

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.713	3
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.693	3
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.667	3
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.643	3
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.642	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.591	3
UniProt:Q53GS9 USP39	1	USP39 [nucleoplasm] (R-HSA-6806793)	0.59	2
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.59	2
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.59	2
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.59	2
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.59	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.589	2
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.567	3
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.527	2
UniProt:Q9UKV3 ACIN1	4	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1 [nucleoplasm] (R-HSA-9770238)	0.527	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.527	2
UniProt:Q9Y3Y2 CHTOP	1	CHTOP [nucleoplasm] (R-HSA-8849147)	0.527	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.525	2
UniProt:O88453	3	Safb [nucleoplasm] (R-RNO-4085343) Safb [nucleoplasm] (R-RNO-4085357) Safb [nucleoplasm] (R-RNO-4085379)	0.524	2

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