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SRPK1 [cytosol]
Stable Identifier
R-HSA-9729349
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SRSF protein kinase 1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of nucleoprotein (Homo sapiens)
SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)
SRPK1/2 [cytosol] (Homo sapiens)
SRPK1:Mg2+ [cytosol] (Homo sapiens)
SRPK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96SB4 SRPK1
Gene Names
SRPK1
Chain
chain:1-655
Reference Genes
BioGPS Gene:6732 SRPK1
COSMIC (genes):SRPK1 SRPK1
CTD Gene:6732 SRPK1
dbSNP Gene:6732 SRPK1
ENSEMBL:ENSG00000096063 SRPK1
HGNC:11305 SRPK1
KEGG:hsa:6732 SRPK1
Monarch:6732 SRPK1
NCBI Gene:6732 SRPK1
OMIM:601939 SRPK1
UCSC:Q96SB4 SRPK1
Reference Transcript
RefSeq:NM_003137.4 SRPK1
Participates
as a component of
SRPK1:Mg2+ [cytosol] (Homo sapiens)
Other forms of this molecule
SRPK1 [nucleoplasm]
Modified Residues
Name
O-phospho-L-serine at 51
Coordinate
51
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 555
Coordinate
555
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_003128.3
Guide to Pharmacology - Targets
2208
ENSEMBL
ENSG00000096063
,
ENST00000423325
,
ENSP00000391069
,
ENST00000373825
,
ENSP00000362931
OpenTargets
ENSG00000096063
ZINC - FDA approved
SRPK1_HUMAN
ZINC - Substances
SRPK1_HUMAN
ZINC - Biogenic
SRPK1_HUMAN
ZINC target
Q96SB4
PRO
Q96SB4
GlyGen
Q96SB4
PDB
5MY8
,
4WUA
,
1WAK
,
5MXX
,
5NNG
,
6FAD
,
3BEG
,
1WBP
,
7DD1
,
5XV7
,
7ZKS
,
7PQS
ZINC - Investigational
SRPK1_HUMAN
GeneCards
SRPK1
HPA
ENSG00000096063-SRPK1
Pharos - Targets
Q96SB4
ZINC - Predictions - Purchasable
SRPK1_HUMAN
HMDB Protein
HMDBP08813
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14498 RBM39
1
RBM39 [nucleoplasm]
(R-HSA-9770254)
0.723
4
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.713
3
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.693
3
UniProt:Q14562 DHX8
1
DHX8 [nucleoplasm]
(R-HSA-5688092)
0.688
4
UniProt:Q15696 ZRSR2
1
ZRSR2 [nucleoplasm]
(R-HSA-8865914)
0.688
3
UniProt:Q8WYQ5 DGCR8
1
DGCR8 [nucleoplasm]
(R-HSA-1482509)
0.67
4
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.667
3
UniProt:Q9P2N5 RBM27
1
RBM27 [nucleoplasm]
(R-HSA-9935838)
0.643
3
UniProt:Q9UKV3 ACIN1
4
ACIN1 [cytosol]
(R-HSA-212519)
ACIN1(1094-1341) [cytosol]
(R-HSA-212516)
ACIN1(1-1093) [cytosol]
(R-HSA-212520)
ACIN1 [nucleoplasm]
(R-HSA-9770238)
0.643
3
UniProt:Q9UQ35 SRRM2
1
SRRM2 [nucleoplasm]
(R-HSA-8865888)
0.643
3
UniProt:Q16629 SRSF7
1
SRSF7 [nucleoplasm]
(R-HSA-72029)
0.642
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.591
3
UniProt:Q05397 PTK2
11
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
PTK2 [cytosol]
(R-HSA-201621)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
0.59
2
UniProt:P50613 CDK7
1
CDK7 [nucleoplasm]
(R-HSA-69218)
0.59
2
UniProt:Q13247 SRSF6
1
SRSF6 [nucleoplasm]
(R-HSA-72026)
0.59
3
UniProt:P84103 SRSF3
1
SRSF3 [nucleoplasm]
(R-HSA-72035)
0.59
2
UniProt:Q53GS9 USP39
1
USP39 [nucleoplasm]
(R-HSA-6806793)
0.59
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.589
2
UniProt:Q96MU7 YTHDC1
1
YTHDC1 [nucleoplasm]
(R-HSA-9935812)
0.567
3
UniProt:P62318 SNRPD3
3
2xMe-SNRPD3 [cytosol]
(R-HSA-191781)
2xMe-SNRPD3 [nucleoplasm]
(R-HSA-192219)
SNRPD3 [nucleoplasm]
(R-HSA-71903)
0.564
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.536
3
UniProt:Q05519 SRSF11
1
SRSF11 [nucleoplasm]
(R-HSA-72058)
0.527
2
UniProt:Q9Y3Y2 CHTOP
1
CHTOP [nucleoplasm]
(R-HSA-8849147)
0.527
2
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.527
2
UniProt:P26368 U2AF2
2
U2AF2 [nucleoplasm]
(R-HSA-71987)
5OHK15,276-U2AF2 [nucleoplasm]
(R-HSA-9630011)
0.527
4
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.527
3
UniProt:P62263 RPS14
2
RPS14 [cytosol]
(R-HSA-72333)
RPS14 [nucleoplasm]
(R-HSA-6790669)
0.527
2
UniProt:P11387 TOP1
2
TOP1 [nucleoplasm]
(R-HSA-4641363)
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
0.527
2
UniProt:Q01130 SRSF2
1
SRSF2 [nucleoplasm]
(R-HSA-72033)
0.527
2
UniProt:O88453
3
Safb [nucleoplasm]
(R-RNO-4085343)
Safb [nucleoplasm]
(R-RNO-4085357)
Safb [nucleoplasm]
(R-RNO-4085379)
0.524
2
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.483
2
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