SARS-CoV-2 N binds to 14-3-3 proteins

Stable Identifier
R-HSA-9729500
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SARS-CoV-2 N binds to 14-3-3 proteins
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
14-3-3 proteins directly shuttle SARS-CoV-1 N protein in a phosphorylation-dependent manner from nucleus to cytosol (Surjit et al, 2005). Polyphosphorylated SARS-CoV-2 N interacts with all seven human 14-3-3 isoforms via its phosphorylated S197. It is probable that this results in the shuttling of phosphorylated N from nucleus to cytosol. Moreover, 14-3-3 binding to p-N may present a cell immune-like response to the viral infection aimed at arresting or neutralizing N activities. On the other hand, in light of the abundance of N protein in the infected cell, p-N may instead arrest 14-3-3 proteins in the cytoplasm and indirectly disrupt cellular processes involving 14-3-3 (Tugaeva et al, 2021).
Literature References
PubMed ID Title Journal Year
33556408 The Mechanism of SARS-CoV-2 Nucleocapsid Protein Recognition by the Human 14-3-3 Proteins

Tugaeva, KV, Ker, DS, Bayfield, OW, Smith, JLR, Antson, AA, Sysoev, AA, Klychnikov, OI, Sluchanko, NN, Hawkins, DEDP

J Mol Biol 2021
16103198 The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation

Mishra, RN, Kumar, R, Reddy, MK, Chow, VT, Surjit, M, Lal, SK

J. Virol. 2005
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-05-03)
Reviewed
Messina, F  (2022-02-18)
Created
Stephan, R  (2021-04-28)
Cite Us!