Reactome | G3BP1 [cytosol]

G3BP1 [cytosol]

Stable Identifier

R-HSA-9729517

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ras GTPase-activating protein-binding protein 1, G3BP-1, GAP SH3 domain-binding protein 1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 N binds to G3BP1,G3BP2 (Homo sapiens)
        
        G3BP1,G3BP2 [cytosol] (Homo sapiens)
        
        G3BP1 [cytosol] (Homo sapiens)
        
        G3BP1,G3BP2:N [cytosol] (Homo sapiens)
        
        G3BP1,G3BP2 [cytosol] (Homo sapiens)
        
        G3BP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13283 G3BP1

Gene Names

G3BP1, G3BP

Chain

initiator methionine:, chain:2-466

Reference Genes

BioGPS Gene:10146 G3BP1

COSMIC (genes):G3BP1 G3BP1

CTD Gene:10146 G3BP1

dbSNP Gene:10146 G3BP1

ENSEMBL:ENSG00000145907 G3BP1

ENSEMBL_homo_sapiens_GENE:ENSG00000145907.16 G3BP1

HGNC:30292 G3BP1

KEGG Gene (Homo sapiens):10146 G3BP1

Monarch:10146 G3BP1

NCBI Gene:10146 G3BP1

OMIM:608431 G3BP1

UCSC:Q13283 G3BP1

Reference Transcript

Other Identifiers

10146

11722586_a_at

11746111_a_at

11754418_s_at

11764223_at

16991261

201503_PM_at

201503_at

201514_PM_s_at

201514_s_at

225007_PM_at

225007_at

242422_PM_at

242422_at

244396_PM_at

244396_at

2577811

2835971

2835972

2835973

2835974

2835978

2835979

2835980

2835981

2835982

2835985

2835986

2835989

2835990

2835992

2835994

2835996

2835998

2836001

2836002

2836003

2836004

2836005

2836006

2836007

2836008

2836009

2836010

2836011

2836012

2836019

41133_at

42924_at

61187_at

63830_at

65859_at

8109368

A_19_P00325917

A_23_P336479

A_33_P3331237

A_33_P3331242

GE62536

GO:0000166

GO:0002376

GO:0003676

GO:0003677

GO:0003678

GO:0003723

GO:0003724

GO:0003729

GO:0003824

GO:0004386

GO:0004518

GO:0004519

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005925

GO:0007265

GO:0010494

GO:0016787

GO:0016887

GO:0023052

GO:0032481

GO:0032508

GO:0033677

GO:0034063

GO:0043024

GO:0043204

GO:0043226

GO:0043229

GO:0045087

GO:0051607

GO:0060090

GO:0062029

GO:0090090

GO:0098542

GO:0140097

GO:0140098

GO:0140657

GO:0140693

GO:1990904

HMNXSV003017847

HMNXSV003035274

Hs.137401.0.S1_3p_at

Hs.220689.0.S2_3p_at

Hs.221576.0.A1_3p_at

Hs.3353.1.A1_3p_at

ILMN_2344455

ILMN_2357809

PH_hs_0022136

PH_hs_0037284

TC05000844.hg

TC05002698.hg

U32519_at

g5031702_3p_a_at

Participates

as a member of

G3BP1,G3BP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_016864411.1, NP_005745.1, XP_006714813.1, XP_016864412.1, NP_938405.1, XP_006714812.1

OpenTargets

ENSG00000145907

IntEnz

3.6.4.13

GeneCards

Q13283

HPA

ENSG00000145907-G3BP1

Ensembl

ENST00000676827, ENSP00000377681, ENSP00000430480, ENSP00000504627, ENST00000394123, ENST00000676978, ENST00000678101, ENSP00000502880, ENST00000522367, ENSP00000503939, ENSP00000348578, ENST00000678070, ENST00000522761, ENSP00000428926, ENST00000677323, ENST00000678925, ENSP00000503039, ENST00000356245, ENSP00000504140, ENSP00000504403, ENSG00000145907, ENST00000677381, ENSP00000503699

PRO

Q13283

Pharos - Targets

Q13283

HMDB Protein

HMDBP08726

PDB

8TH6, 7S17, 5FW5, 7XHF, 4FCM, 8TH7, 7XHG, 6TA7, 8TH1, 3Q90, 7SUO, 8V1L, 4IIA, 4FCJ, 8TH5

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.984	71
UniProt:Q14694 USP10	3	USP10 [nucleoplasm] (R-HSA-3222218) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [cytosol] (R-HSA-6782974)	0.941	16
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.924	12
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	16
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.556	3
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.527	2
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.527	2
UniProt:P62847 RPS24	2	RPS24 [nucleoplasm] (R-HSA-6791186) RPS24 [cytosol] (R-HSA-72355)	0.527	2
UniProt:P35658 NUP214	2	NUP214 [nucleoplasm] (R-HSA-451222) NUP214 [cytosol] (R-HSA-157691)	0.527	2
UniProt:P46781 RPS9	2	RPS9 [nucleoplasm] (R-HSA-6790663) RPS9 [cytosol] (R-HSA-72387)	0.527	2
UniProt:P62244 RPS15A	2	RPS15A [nucleoplasm] (R-HSA-6791191) RPS15A [cytosol] (R-HSA-72345)	0.527	2
UniProt:P19525 EIF2AK2	5	p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) p-EIF2AK2 [cytosol] (R-HSA-9833834) EIF2AK2 [cytosol] (R-HSA-168699)	0.527	2
UniProt:P46782 RPS5	2	RPS5 [nucleoplasm] (R-HSA-6791188) RPS5 [cytosol] (R-HSA-72379)	0.527	2
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.527	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	2
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.524	2
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.524	2
UniProt:Q14258 TRIM25	2	TRIM25 [nucleoplasm] (R-HSA-5653667) TRIM25 [cytosol] (R-HSA-918186)	0.524	2
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.491	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4

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