Reactome | NLRP12(241-1061) [cytosol]

NLRP12(241-1061) [cytosol]

Stable Identifier

R-HSA-9729690

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NACHT, LRR and PYD domains-containing protein 12, NAL12_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 3CLpro dimer cleaves NLRP12 (Homo sapiens)
        
        NLRP12(241-1061) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P59046 NLRP12

Gene Names

NLRP12, NALP12, PYPAF7, RNO

Chain

chain:1-1061

Reference Genes

BioGPS Gene:91662 NLRP12

COSMIC (genes):NLRP12 NLRP12

CTD Gene:91662 NLRP12

dbSNP Gene:91662 NLRP12

ENSEMBL:ENSG00000142405 NLRP12

HGNC:22938 NLRP12

KEGG:hsa:91662 NLRP12

Monarch:91662 NLRP12

NCBI Gene:91662 NLRP12

OMIM:609648 NLRP12

UCSC:P59046 NLRP12

Reference Transcript

Other Identifiers

11740396_a_at

1554952_PM_s_at

1554952_s_at

16875219

223944_PM_at

223944_at

3870391

3870392

3870393

3870394

3870395

3870397

3870398

3870399

3870400

3870401

3870402

3870403

3870404

3870405

3870406

3870407

3870408

3870409

3870410

3870411

3870412

3870413

3870414

8039096

91662

A_23_P101434

A_23_P90041

GE83639

GO:0001818

GO:0002376

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006355

GO:0006915

GO:0006919

GO:0007165

GO:0008656

GO:0009968

GO:0012501

GO:0030674

GO:0031953

GO:0032088

GO:0032661

GO:0032692

GO:0032715

GO:0032731

GO:0036336

GO:0043122

GO:0043124

GO:0043281

GO:0045345

GO:0045751

GO:0048870

GO:0050728

GO:0050729

GO:0060090

GO:0070371

GO:0070373

GO:0071345

GO:0098772

GO:1901223

GO:1901224

HMNXSV003057379

ILMN_1716105

ILMN_1739815

ILMN_1758735

PH_hs_0017538

TC19001826.hg

g13182796_3p_s_at

Participates

as an output of

SARS-CoV-2 3CLpro dimer cleaves NLRP12 (Homo sapiens)

Other forms of this molecule

NLRP12(1-937) [cytosol]

NLRP12(938-1061) [cytosol]

NLRP12(1-240) [cytosol]

NLRP12 [cytosol]

Cross References

RefSeq

NP_001264055.1, NP_001264058.1, NP_653288.1

Guide to Pharmacology - Targets

1779

ENSEMBL

ENSP00000375653, ENST00000324134, ENST00000391775, ENST00000391773, ENSP00000375655, ENSP00000319377

OpenTargets

ENSG00000142405

HPA

ENSG00000142405-NLRP12

PRO

P59046

Pharos - Targets

P59046

GlyGen

P59046

PDB

5H7N, 2L6A, 4XHS

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y228 T3JAM			0.508	2
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.508	4
UniProt:P08631-1 HCK			0.463	2

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