SARS-CoV-2 nsp3 cleaves IRF3

Stable Identifier
R-HSA-9729730
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
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SARS-CoV-2 nsp3 cleaves IRF3
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SARS-CoV-2 nsp3 protease (PLpro) specifically cleaves IRF3 at the LGGG motif and decreases IRF3 levels in COVID-19. Infection with a mutant having inhibited protease activity did not decrease IRF3 levels, demonstrating that the decrease of IRF3 is linked to the protease activity of nsp3 (Moustaqil et al, 2021). The nsp3-mediated cleavage of IRF3 attenuates type I interferon responses.

Literature References
PubMed ID Title Journal Year
33372854 SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Moustaqil, M, Jacques, D, Gambin, Y, Rudolffi-Soto, P, Freiberg, AN, Hunter, DJB, Chiu, HP, Bhumkar, A, Lee, B, Van Tol, S, Ollivier, E, Sierecki, E, Stevens, C

Emerg Microbes Infect 2021
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Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of N-glycan nsp3 [endoplasmic reticulum membrane]

Physical Entity
N-glycan nsp3 [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-06-11)
Reviewed
Messina, F  (2022-02-18)
Created
Stephan, R  (2021-05-03)
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