Reactome | IKBKE:IKBKE [cytosol]

IKBKE:IKBKE [cytosol]

Stable Identifier

R-HSA-9730425

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Synonyms

IKBKE homodimer

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
        
        TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
        
        IKBKE:IKBKE [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
        
        IKBKE:IKBKE [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
23453969	IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex Shen, RR, Hahn, WC, Chen, ZJ, Xu, M, Lock, YJ, Zhou, AY, Kim, E	Cell Rep	2013

Participants

components

x 2 IKBKE [cytosol] (Homo sapiens)

Participates

as a component of

IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)

as a member of

TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)

Inferred To

IKBKE:IKBKE [cytosol] (Bos taurus)

IKBKE:IKBKE [cytosol] (Canis familiaris)

IKBKE:IKBKE [cytosol] (Gallus gallus)

IKBKE:IKBKE [cytosol] (Mus musculus)

IKBKE:IKBKE [cytosol] (Rattus norvegicus)

IKBKE:IKBKE [cytosol] (Sus scrofa)

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