SARS-CoV-2 3a induces potassium efflux

Stable Identifier
R-HSA-9730521
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
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SARS-CoV-2 viroporin 3a (ORF3a) is a membrane protein that translocates to the plasma membrane and probably, via shedding like SARS-CoV-1 3a, to other cells. It forms a homotetrameric inward-rectifying potassium ion channel which is inhibited by barium ions. Blocking potassium efflux from the cell impaired protein 3a's ability to trigger assembly of both ASC-independent and -dependent NLRP3 inflammasomes, upon infection of A549 and HEK-293T cells with SARS-CoV-2 (Xu et al, 2020).

Literature References
PubMed ID Title Journal Year
35066302 SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

Bhaduri-McIntosh, S, Xu, H, Chitre, SA, Loeb, JC, McIntosh, MT, Akinyemi, IA, Lednicky, JA

Virology 2022
Participants
Input
Participates
Catalyst Activity

inward rectifier potassium channel activity of O-glycosyl 3a tetramer [plasma membrane]

Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Rhea
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