SARS-CoV-2 3a binds to STING

Stable Identifier
R-HSA-9730528
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
ReviewStatus
5/5
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SARS-CoV-2 3a binds to STING
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STING is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon. RNA viral infection can also lead to the activation of STING through viral–cellular membrane fusion and viral infection-induced mitochondrial damage. SARS-CoV-2 ORF3a (3a) has the ability to specifically antagonize the immune activation induced by cGAS-STING by binding to STING and selectively suppressing cGAS-STING-mediated downstream signaling (Rui et al, 2021).
Literature References
PubMed ID Title Journal Year
33723219 Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins

Cai, Y, Huang, D, Lou, M, Dong, Q, Zheng, S, Wang, M, Shen, S, Xu, R, Zheng, W, Zhao, N, Shi, Y, Yu, XF, Hu, Y, Rui, Y, Chen, S, Su, J

Signal Transduct Target Ther 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-05-07)
Reviewed
Messina, F  (2022-02-18)
Created
Stephan, R  (2021-05-07)
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