SARS-CoV-1 nsp3 binds to IRF3

Stable Identifier
R-HSA-9731009
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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SARS-CoV-1 nsp3 binds to IRF3
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Besides its main deubiquitinase activity as part of the viral replication-transcription complex, SARS-CoV-1 papain-like protease (PLpro, nsp3) also binds directly to IRF3, inhibiting IRF3 phosphorylation and subsequent dimerization, nuclear translocation, and activation of expression of IRF-3 target genes (Devaraj et al, 2007; Chen et al, 2014). This binding probably happens in cytosol, where nascent IRF3 is localized.
Literature References
PubMed ID Title Journal Year
17761676 Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus

Tseng, M, Baker, SC, Wang, N, Devaraj, SG, Li, K, Peters, CJ, Tseng, CT, Lin, R, Barretto, N, Chen, Z, Chen, Z

J Biol Chem 2007
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Input
Output
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Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2021-05-07)
Reviewed
D'Eustachio, P  (2021-01-26)
Created
Stephan, R  (2021-05-12)
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