SARS-CoV-1 M binds to PDPK1

Stable Identifier
R-HSA-9731018
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
plasma membrane
ReviewStatus
5/5
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SARS-CoV-1 M binds to PDPK1
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SARS-CoV-1 M-protein induces apoptosis through caspase 8 and caspase 9 activation by down-regulating the PKB/Akt survival signalling cascade. Mechanistically M, probably located in the plasma membrane (Tseng et al, 2010), binds to 3-phosphoinositide-dependent protein kinase 1 (PDPK1), inhibiting its phosphorylation activity on the PH domain, preferentially perturbing the activity of any PDK1 downstream substrate whose phosphorylation is mediated through this domain. This mainly affects PKB/Akt activation, which is down-regulated (Chan et al, 2007; Tsoi et al, 2014).
Literature References
PubMed ID Title Journal Year
25271362 The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling

Lau, KF, Tsoi, H, Chen, ZS, Tsui, SK, Li, L, Chan, HY

Biochem J 2014
20154085 Self-assembly of severe acute respiratory syndrome coronavirus membrane protein

Tseng, YT, Wang, SM, Chiang, CC, Huang, KJ, Lee, AI, Wang, CT

J. Biol. Chem. 2010
17306213 The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway

Ma, CW, Chan, CM, Chan, WY, Chan, HY

Arch Biochem Biophys 2007
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2021-05-11)
Reviewed
D'Eustachio, P  (2021-01-26)
Created
Stephan, R  (2021-05-12)
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