Reactome | NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP

NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP

Stable Identifier

R-HSA-9731590

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+

ReviewStatus

5/5

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NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP

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NUDT1 (MTH1) catalyzes the reaction of O6-methyl-dGTP and water to form O6-methyl-dGMP and PPi (pyrophosphate) (Jemth et al. 2018). Four NUDT1 proteins have been identified, encoded by a single gene with alternative start codons (Oda et al. 1999). The shortest of these, NUDT1 p18, has been shown to be enzymatically active as a monomer associated with a magnesium ion (Mishima et al. 2004; Sakumi et al. 1993; Takagi et al. 2012). The longer isoforms all consist of the p18 polypeptide with aminoterminal extensions and are presumed to be active as well but have not been experimentally characterized. The p18 isoform is predominantly cytosolic (Kang et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
15133035	Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates Mishima, M, Shirakawa, M, Itoh, N, Takahashi, M, Furuichi, M, Iwai, S, Nakabeppu, Y, Yamagata, Y, Sakai, Y, Kamiya, H	J. Biol. Chem.	2004
30304478	MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP Vallin, KSA, Gustafsson, R, Jemth, AS, Homan, E, Almlöf, I, Henriksson, L, Helleday, T, Stenmark, P, Sarno, A, Warpman Berglund, U, Rasti, A, Bräutigam, L	Nucleic Acids Res	2018
22556419	Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2 Takagi, Y, Ito, R, Sekiguchi, M, Yamagata, Y, Setoyama, D, Kamiya, H	J. Biol. Chem.	2012
10536140	Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism Itoh, R, Nishioka, K, Oda, H, Taketomi, A, Suzuki, T, Maruyama, R, Nakabeppu, Y, Sekiguchi, M, Yakushiji, H	Nucleic Acids Res.	1999
7782328	Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria Iyama, A, Furuichi, M, Fujiwara, T, Nishida, J, Nakabeppu, Y, Kang, D, Sekiguchi, M, Takeshige, K	J. Biol. Chem.	1995
8226881	Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis Tsuzuki, T, Kakuma, T, Furuichi, M, Maki, H, Kawabata, S, Sekiguchi, M, Sakumi, K	J. Biol. Chem.	1993