Reactome | ZIC1 [nucleoplasm]

ZIC1 [nucleoplasm]

Stable Identifier

R-HSA-9731648

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Zinc finger protein ZIC 1, ZIC1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15915 ZIC1

Gene Names

ZIC1, ZIC, ZNF201

Chain

chain:1-447

Reference Genes

BioGPS Gene:7545 ZIC1

COSMIC (genes):ZIC1 ZIC1

CTD Gene:7545 ZIC1

dbSNP Gene:7545 ZIC1

ENSEMBL:ENSG00000152977 ZIC1

HGNC:12872 ZIC1

Monarch:7545 ZIC1

NCBI Gene:7545 ZIC1

OMIM:600470 ZIC1

UCSC:Q15915 ZIC1

Reference Transcript

RefSeq:NM_003412.3 ZIC1

Other Identifiers

11731331_at

11731332_at

206373_PM_at

206373_at

236896_PM_at

236896_at

241440_PM_at

241440_at

2646819

2646824

2646825

2646826

2646829

2646833

2646834

2646835

2646836

2646837

2646838

2646839

2646840

2646847

2646850

2646851

36308_at

47852_r_at

7545

80089_at

8083233

A_23_P367618

A_32_P86067

A_33_P3384362

D76435_at

GE530932

GE577453

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006355

GO:0006357

GO:0007389

GO:0007399

GO:0007417

GO:0007420

GO:0007628

GO:0008589

GO:0010467

GO:0021510

GO:0021766

GO:0021772

GO:0030154

GO:0030900

GO:0042307

GO:0042472

GO:0043226

GO:0045893

GO:0045944

GO:0046872

GO:0048856

GO:0098727

GO:0140110

GO:1990837

HMNXSV003026746

HMNXSV003048509

HMNXSV003051371

Hs.146067.0.A1_3p_at

Hs.7177.0.A1_3p_at

ILMN_1745684

ILMN_1774005

PH_hs_0003068

PH_hs_0008698

TC03002582.hg

g4507970_3p_at

p22163

Participates

as an output of

Expression of ZIC1 in the neural plate border (Homo sapiens)

This entity regulates

Positively

FOXD3 gene expression (Homo sapiens)

Cross References

OpenTargets

ENSG00000152977

ENSEMBL

ENST00000282928, ENSP00000282928

HPA

ENSG00000152977-ZIC1

PRO

Q15915

Pharos - Targets

Q15915

Orphanet

ZIC1

Interactors (102)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRY6 PLS3			0.556	3
UniProt:Q9BYR7 KRTAP3-2	1	KRTAP3-2 [cytosol] (R-HSA-6809857)	0.556	3
UniProt:Q5TA45 CPSF3L	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.556	3
UniProt:Q3SYF9 KRTAP19-7	1	KRTAP19-7 [cytosol] (R-HSA-6810305)	0.556	3
UniProt:Q53HC5 KLH26			0.556	3
UniProt:Q9UBV8 PEF1			0.556	3
UniProt:Q8NI38 IKBD			0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:Q8IUB9 KRTAP19-1	1	KRTAP19-1 [cytosol] (R-HSA-6810285)	0.556	3
UniProt:Q8N6F8 MET27			0.556	3
UniProt:P35250-2 RFC2			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q52LG2 KRTAP13-2	1	KRTAP13-2 [cytosol] (R-HSA-6810274)	0.556	3
UniProt:O43186 CRX			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q6NVV7 CDPF1			0.556	3
UniProt:Q8NFV4-4 ABHD11			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q3LI59 KRTAP21-2	1	KRTAP21-2 [cytosol] (R-HSA-6810245)	0.556	3
UniProt:O60806 TBX19			0.556	3
UniProt:Q9Y6H3 ATP23			0.556	3
UniProt:Q86WV8 Q86WV8			0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	5
UniProt:Q6NVU6 UFSP1			0.556	3
UniProt:Q53HV7-2 SMUG1			0.556	3
UniProt:P59990 KRTAP12-1	1	KRTAP12-1 [cytosol] (R-HSA-6810248)	0.556	3
UniProt:Q99932-2 SPAG8			0.556	5
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	3
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.556	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.556	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.556	3
UniProt:Q93062-3 RBPMS			0.556	3
UniProt:Q496A3 SPAS1			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:A1KXE4-2 FAM168B			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
IntAct:EBI-22320186 CCSB ORF ID			0.556	3
UniProt:Q96AZ1 EFMT3			0.556	3
IntAct:EBI-22461217 CCSB ORF ID			0.556	3
IntAct:EBI-23202138 CCSB ORF ID			0.556	3
UniProt:Q9NXR5-2 ANKRD10			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:Q99732 LITAF			0.556	3
UniProt:Q6S9Z5 ZN474			0.556	3
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.556	3
UniProt:Q8IUC2 KRTAP8-1	1	KRTAP8-1 [cytosol] (R-HSA-6810288)	0.556	5
UniProt:Q8IUC3 KRA71			0.556	3
UniProt:A0PJW8 DAPL1			0.556	3
UniProt:Q9H7B4 SMYD3	1	SMYD3 [nucleoplasm] (R-HSA-5637688)	0.556	3
UniProt:Q9NR55 BATF3			0.556	3
UniProt:Q9H5F2 CFA68			0.556	3
UniProt:Q86XJ1 GA2L3			0.556	3
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.556	3
UniProt:Q3LHN2 KRTAP19-2	1	KRTAP19-2 [cytosol] (R-HSA-6810262)	0.556	3
UniProt:Q9HDD0 PLAAT1	1	HRASLS [cytosol] (R-HSA-8858537)	0.556	3
UniProt:Q3LI76 KRTAP15-1	1	KRTAP15-1 [cytosol] (R-HSA-6810304)	0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
IntAct:EBI-22616457 CCSB ORF ID			0.556	5
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q3LI64 KRTAP6-1	1	KRTAP6-1 [cytosol] (R-HSA-6810298)	0.556	3
UniProt:O60911 CTSV	4	CTSL2 [endolysosome lumen] (R-HSA-4127477) CTSL2 [extracellular region] (R-HSA-2228669) CTSL2 [early endosome lumen] (R-HSA-4127471) CTSL2 [lysosomal lumen] (R-HSA-1181232)	0.527	2
UniProt:Q6ZVX7 FBX50			0.527	2
UniProt:P09668 CTSH	8	CTSH(116-335) [lysosomal lumen] (R-HSA-1181224) CTSH(293-335) [multivesicular body lumen] (R-HSA-5685888) CTSH(116-292) [multivesicular body lumen] (R-HSA-5685904) CTSH(98-105) [multivesicular body lumen] (R-HSA-5685877) CTSH(116-335) [ficolin-1-rich granule lumen] (R-HSA-6801295) CTSH(116-335) [tertiary granule lumen] (R-HSA-6801278) CTSH(116-335) [extracellular region] (R-HSA-6801616) CTSH(116-335) [secretory granule lumen] (R-HSA-6801307)	0.527	2
UniProt:O75342 ALOX12B	1	ALOX12B [cytosol] (R-HSA-2142832)	0.527	2
UniProt:P01040 CSTA	2	CSTA [cornified envelope] (R-HSA-8934840) CSTA [cytosol] (R-HSA-6814194)	0.527	2
UniProt:Q6P4A8 PLBD1	1	PLBD1 [cytosol] (R-HSA-1524034)	0.527	2
UniProt:Q96FQ6 S10AG			0.527	2
UniProt:Q96L46 CAPNS2	2	CAPNS2 [plasma membrane] (R-HSA-8863453) CAPNS2 [cytosol] (R-HSA-8848629)	0.527	2
UniProt:P42357 HAL	1	HAL [cytosol] (R-HSA-70897)	0.527	2
UniProt:P25815 S100P	2	S100P [extracellular region] (R-HSA-6804809) S100P [secretory granule lumen] (R-HSA-6804782)	0.527	2
UniProt:P48594 SPB4			0.527	2
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.527	2
UniProt:Q9H1E1 RNASE7	1	RNASE7 [extracellular region] (R-HSA-6803118)	0.527	2
UniProt:Q8NEX9 SDR9C7	1	SDR9C7 [endoplasmic reticulum membrane] (R-HSA-4084690)	0.527	2
UniProt:P29508 SERPINB3	2	SERPINB3 [extracellular region] (R-HSA-6806189) SERPINB3 [azurophil granule lumen] (R-HSA-6799340)	0.527	2
UniProt:Q9UI42 CBPA4			0.527	2
UniProt:P31944 CASP14	2	CASP14(6-146) [cytosol] (R-HSA-8847667) CASP14(153-242) [cytosol] (R-HSA-8847687)	0.527	2
UniProt:P31151 S100A7	2	S100A7 [azurophil granule lumen] (R-HSA-6799207) S100A7 [extracellular region] (R-HSA-5432925)	0.527	2
UniProt:P30740 SERPINB1	2	SERPINB1 [extracellular region] (R-HSA-6804818) SERPINB1 [secretory granule lumen] (R-HSA-6804786)	0.527	2
UniProt:P01011 SERPINA3	4	SERPINA3 [platelet alpha granule lumen] (R-HSA-8848913) SERPINA3 [azurophil granule lumen] (R-HSA-6798754) SERPINA3 [extracellular region] (R-HSA-6806173) SERPINA3 [secretory granule lumen] (R-HSA-6801018)	0.527	2
UniProt:Q96QA5 GSDMA			0.527	2
UniProt:P06702 S100A9	3	S100A9 [cytosol] (R-HSA-9626869) S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [extracellular region] (R-HSA-5432857)	0.527	2
UniProt:P07476 IVL	2	IVL [cornified envelope] (R-HSA-8847720) IVL [cytosol] (R-HSA-6810837)	0.527	2
UniProt:P25311 AZGP1	1	AZGP1 [extracellular region] (R-HSA-5215961)	0.527	2
UniProt:P17900 GM2A	3	GM2A(32-193) [lysosomal lumen] (R-HSA-1605614) GM2A(32-193) [extracellular region] (R-HSA-6806181) GM2A(32-193) [azurophil granule lumen] (R-HSA-6799160)	0.527	2
UniProt:P22735 TGM1	3	TGM1 [cytosol] (R-HSA-6813756) TGM1 [cornified envelope] (R-HSA-8847706) TGM1 [plasma membrane] (R-HSA-6813757)	0.527	2
UniProt:Q9BYJ1 ALOXE3	1	ALOXE3 [cytosol] (R-HSA-8942204)	0.527	2
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.527	2

Cite Us!