FOXD3 gene expression

Stable Identifier
R-HSA-9732107
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FOXD3 gene expression
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FOXD3 is a negative regulator of melanocyte fate determination. FOXD3 is expressed in neural crest cells in a manner that depends on SNAIL2 and SOX9. SNAIL2 expression, in turn, depends on transcriptional regulation by neural border fate regulators ZIC1 and PAX3 (Plouhinec et al, 2014; Nitzan et al, 2013; Millet et al, 2013; Bae et al, 2014). These premigratory neural crest cells give rise to an early-migrating lineage that produces Schwann cell precursors and glial and neural cells and a later-migrating lineage that gives rise to the melanocytic lineage (reviewed in Mort et al, 2015; White and Zon, 2008).

Expression of FOXD3 is maintained in the early-departing, ventrally-migrating cell population that gives rise to neural tissue, Schwann cells and glia, but is repressed prior to the delamination and migration of later-departing cells that travel dorsolaterally and give rise to the melanocyte lineage. The mechanisms of FOXD3 repression are not worked out in detail, but repression in zebrafish depends on HDAC1 (Ignatius et al, 2008).
Literature References
PubMed ID Title Journal Year
24360908 Identification of Pax3 and Zic1 targets in the developing neural crest

Bae, CJ, Park, BY, Lee, YH, Tobias, JW, Hong, CS, Saint-Jeannet, JP

Dev Biol 2014
23615280 A dynamic code of dorsal neural tube genes regulates the segregation between neurogenic and melanogenic neural crest cells

Nitzan, E, Krispin, S, Pfaltzgraff, ER, Klar, A, Labosky, PA, Kalcheim, C

Development 2013
23509273 Pax3 and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos

Milet, C, Maczkowiak, F, Roche, DD, Monsoro-Burq, AH

Proc Natl Acad Sci U S A 2013
18786412 Melanocytes in development, regeneration, and cancer

White, RM, Zon, LI

Cell Stem Cell 2008
18068699 colgate/hdac1 Repression of foxd3 expression is required to permit mitfa-dependent melanogenesis

Ignatius, MS, Moose, HE, El-Hodiri, HM, Henion, PD

Dev Biol 2008
25670789 The melanocyte lineage in development and disease

Mort, RL, Jackson, IJ, Patton, EE

Development 2015
24360906 Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers

Plouhinec, JL, Roche, DD, Pegoraro, C, Figueiredo, AL, Maczkowiak, F, Brunet, LJ, Milet, C, Vert, JP, Pollet, N, Harland, RM, Monsoro-Burq, AH

Dev Biol 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
HDAC1 [nucleoplasm] (Homo sapiens)
Positively by
Regulator
ZIC1 [nucleoplasm] (Homo sapiens)
Regulator
SOX9 [nucleoplasm] (Homo sapiens)
Regulator
PAX3 [nucleoplasm] (Homo sapiens)
Regulator
SNAI2 [nucleoplasm] (Homo sapiens)
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2021-05-26)
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